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Articles (77)
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Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies

WESSALE, Jerry L., ADLER, Andrew L., NOVOSAD, Eugene I., CALZADILLA, Samuel V., DAYTON, Brian D., MARSH, Kennan C., WINN, Martin, JAE, Hwan-Soo, GELDERN, Thomas W.von, OPGENORTH, Terry J., WU-WONG, J.

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 164 KB

english, 2002

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies

WU-WONG, J. Ruth, DIXON, Douglas B., CHIOU, William J., SORENSEN, Brian K., LIU, Gang, JAE, H.-S., TASKER, Andrew, GELDERN, Thomas W. Von, WINN, Martin, OPGENORTH, Terry J.

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 120 KB

english, 2002

VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells

J. Ruth Wu-Wong, Masaki Nakane, Junli Ma, Xiaoan Ruan, Paul E. Kroeger

Journal:

Journal of Cellular Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 247 KB

english, 2007

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ETA receptor selectivity

Steven A Boyd, Robert A Mantei, Andrew S Tasker, Gang Liu, Bryan K Sorensen, Kenneth J Henry Jr, Thomas W von Geldern, Martin Winn, Jinshyun R Wu-Wong, William J Chiou, Douglas B Dixon, Charles W Hutc

Journal:

Bioorganic & Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 234 KB

english, 1999

Expression of VDR and CYP24A1 mRNA in human tumors

Mark G. Anderson, Masaki Nakane, Xiaoan Ruan, Paul E. Kroeger, J. Ruth Wu-Wong

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 297 KB

english, 2006

Differential Effects of Vitamin D Receptor Agonists on Gene Expression in Neonatal Rat Cardiomyocytes

J. Ruth Wu-Wong, Yung-Wu Chen, Masaki Nakane, Myles Wolf

Journal:

Cardiovascular Drugs and Therapy

Année:

2011

Langue:

english

Fichier:

PDF, 407 KB

english, 2011

Potential for vitamin D receptor agonists in the treatment of cardiovascular disease

JR Wu-Wong

Journal:

British Journal of Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 691 KB

english, 2009

VS-105: a novel vitamin D receptor modulator with cardiovascular protective effects

J Ruth Wu-Wong, Megumi Kawai, Yung-wu Chen, Masaki Nakane

Journal:

British Journal of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2011

Vitamin D analogs down-regulate plasminogen activator inhibitor-1 in human coronary artery smooth muscle cells

J. RUTH WU-WONG, M. NAKANE, J. MA, A. L. COOK

Journal:

Journal of Thrombosis and Haemostasis

Année:

2005

Langue:

english

Fichier:

PDF, 103 KB

english, 2005

Statins do not directly activate vitamin D receptor

J. R. WU-WONG, M. NAKANE, J. MA, T. R. JU

Journal:

Journal of Thrombosis and Haemostasis

Année:

2007

Langue:

english

Fichier:

PDF, 122 KB

english, 2007

ChemInform Abstract: Azole Endothelin Antagonists. Part 2. Structure-Activity Studies.

T. W. VON GELDERN, J. A. KESTER, R. BAL, J. R. WU-WONG, W. CHIOU, D. B. DIXON, T. J. OPGENORTH

Journal:

ChemInform

Année:

1996

Fichier:

PDF, 28 KB

1996

ChemInform Abstract: Azole Endothelin Antagonists. Part 1. A Receptor Model Explains an Unusual Structure-Activity Profile.

T. W. VON GELDERN, C. HUTCHINS, J. A. KESTER, J. R. WU-WONG, W. CHIOU, D. B. DIXON, T. J. OPGENORTH

Journal:

ChemInform

Année:

1996

Langue:

english

Fichier:

PDF, 31 KB

english, 1996

ChemInform Abstract: 2,4-Diarylpyrrolidine-3-carboxylic Acids - Potent ETA Selective Endothelin Receptor Antagonists. Part 1. Discovery of A-127722.

M. WINN, T. W. VON GELDERN, T. J. OPGENORTH, H.-S. JAE, A. S. TASKER, S. A. BOYD, J. A. KESTER, R. A. MANTEI, R. BAL, B. K. SORENSEN, J. R. WU-WONG, W. J. CHIOU, D. B. DIXON, E. I. NOVOSAD, L. HERNAND

Journal:

ChemInform

Année:

1996

Langue:

english

Fichier:

PDF, 32 KB

english, 1996

Pharmacology of A-216546: a highly selective antagonist for endothelin ETA receptor

Jinshyun R Wu-Wong, Douglas B Dixon, William J Chiou, Brian D Dayton, Eugene I Novosad, Andrew L Adler, Jerry L Wessale, Samuel V Calzadilla, Lisa Hernandez, Kennan C Marsh, Gang Liu, Bruce Szczepanki

Journal:

European Journal of Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 386 KB

english, 1999

63: Generalized Vasoconstriction and Acute Hypertension Produced by the Calcimimetic, Cinacalcet, in Uremic and Normal Rats

Ryan M. Fryer, Jason A. Segreti, Kristin A. Koch, Masaki Nakane, J. Ruth Wu-Wong, Glenn A. Reinhart

Journal:

American Journal of Kidney Diseases

Année:

2007

Langue:

english

Fichier:

PDF, 187 KB

english, 2007

240: Effects of Cinacalcet on Emesis and Cerebral Blood Volume

J. Ruth Wu-Wong, Chih-Liang Chin, Thomas K. Shaughnessy, Gerard B. Fox

Journal:

American Journal of Kidney Diseases

Année:

2007

Langue:

english

Fichier:

PDF, 207 KB

english, 2007

Characterization of endothelin converting enzyme in rat lung

Jinshyun R. Wu-Wong, Gerald P. Budzik, Edward M. Devine, Terry J. Opgenorth

Journal:

Biochemical and Biophysical Research Communications

Année:

1990

Langue:

english

Fichier:

PDF, 403 KB

english, 1990

Endothelins and endothelin receptor antagonists: Binding to plasma proteins

Jinshyun R. Wu-Wong, William J. Chiou, Daniel J. Huffman, Martin Winn, Thomas W. von Geldern, Terry J. Opgenorth

Journal:

Life Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 709 KB

english, 1996

Differential effects of Vitamin D analogs on bone formation and resorption

Masaki Nakane, Thomas A. Fey, Doug B. Dixon, Junli Ma, Michael E. Brune, Yan Chun Li, J. Ruth Wu-Wong

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 228 KB

english, 2006

Differential effects of Vitamin D analogs on calcium transport

Masaki Nakane, Junli Ma, Andrew E. Rose, Mark A. Osinski, J. Ruth Wu-Wong

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 360 KB

english, 2007

Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells

J. Ruth Wu-Wong, Masaki Nakane, Junli Ma

Journal:

Thrombosis Research

Année:

2006

Langue:

english

Fichier:

PDF, 170 KB

english, 2006

The effects of diminishing albumin binding to some Endothelin receptor antagonists

Bruce G. Szczepankiewicz, Radhika B. Bal, Thomas W. von Geldern, Jinshyun R. Wu-Wong, William J. Chiou, Douglas B. Dixon, Terry J. Opgenorth, Daniel J. Hoffman, Anthony J. Borre, Kennan C. Marsh, Bach

Journal:

Life Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 602 KB

english, 1998

Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay

Brian D Dayton, William J. Chiou, Terry J. Opgenorth, Jinshyun R. Wu-Wong

Journal:

Life Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 694 KB

english, 2000

New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade

Joel B Nelson, Son H Nguyen, Jinshyun R Wu-Wong, Terry J Opgenorth, Douglas B Dixon, Leland W.K Chung, Nozomu Inoue

Journal:

Urology

Année:

1999

Langue:

english

Fichier:

PDF, 270 KB

english, 1999

SV40 virus transformation down-regulates endothelin receptor

William J. Chiou, Jiahong Wang, Cathleen E. Berg, Jinshyun R. Wu-Wong

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

1999

Langue:

english

Fichier:

PDF, 467 KB

english, 1999

Azole Endothelin Antagonists. 3. Using Δ log P as a Tool To Improve Absorption

von Geldern, Thomas W., Hoffman, Daniel J., Kester, Jeffrey A., Nellans, Hugh N., Dayton, Brian D., Calzadilla, Samuel V., Marsh, Kennan C., Hernandez, Lisa, Chiou, William, Dixon, Douglas B., Wu-Wong

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 355 KB

english, 1996

Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells

J. Ruth Wu-Wong, Masaki Nakane, Junli Ma, Xiaoan Ruan, Paul E. Kroeger

Journal:

Atherosclerosis

Année:

2006

Langue:

english

Fichier:

PDF, 306 KB

english, 2006

New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

Szczepankiewicz, Bruce G., Liu, Gang, Jae, Hwan-Soo, Tasker, Andrew S., Gunawardana, Indrani W., von Geldern, Thomas W., Gwaltney, Stephen L., Wu-Wong, J. Ruth, Gehrke, Laura, Chiou, William J., Credo

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 224 KB

english, 2001

Endothelin receptor antagonists exhibit diminishing potency following incubation with agonist

Jinshyun R. Wu-Wong, William J. Chiou, Kurt E. Naugles Jr., Terry J. Opgenorth

Journal:

Life Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 528 KB

english, 1994

Characterization of two endothelin converting enzymes and their preference for big endothelin-1 and -2 as substrates

William J. Chiou, Kazumi Shiosaki, Andrew S. Tasker, Jinshyun R. Wu-Wong

Journal:

Life Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 464 KB

english, 1994

Azole Endothelin Antagonists. 2. Structure−Activity Studies

von Geldern, Thomas W., Kester, Jeffrey A., Bal, Radhika, Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 380 KB

english, 1996

Synthesis of VS-105: A novel and potent vitamin D receptor agonist with reduced hypercalcemic effects

Chen, Barbara, Kawai, Megumi, Wu-Wong, J. Ruth

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 540 KB

english, 2013

Mapping the time-dependent effects of paricalcitol on serum calcium, phosphorus and parathyroid hormone levels in 5/6 nephrectomized uremic rats

Wu-Wong, J. Ruth, Nakane, Masaki, Chen, Yung-wu

Journal:

Life Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 374 KB

english, 2013

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ET A Antagonist (A-216546)

Liu, Gang, Henry,, Kenneth J., Szczepankiewicz, Bruce G., Winn, Martin, Kozmina, Natasha S., Boyd, Steven A., Wasicak, James, von Geldern, Thomas W., Wu-Wong, Jinshyun R., Chiou, William J., Dixon, Do

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 253 KB

english, 1998

Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung

Shiosaki, Kazumi, Tasker, Andrew S., Sullivan, Gerard M., Sorensen, Bryan K., von Geldern, Thomas W., Wu-Wong, Jinshyun R., Marselle, Carol A., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1993

Azole Endothelin Antagonists. 1. A Receptor Model Explains an Unusual Structure−Activity Profile

von Geldern, Thomas W., Hutchins, Charles, Kester, Jeffrey A., Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 334 KB

english, 1996

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Winn, Martin, von Geldern, Thomas W., Opgenorth, Terry J., Jae, Hwan-Soo, Tasker, Andrew S., Boyd, Steven A., Kester, Jeffrey A., Mantei, Robert A., Bal, Radhika, Sorensen, Bryan K., Wu-Wong, Jinshyun

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 402 KB

english, 1996

Biochemical Characterization of Endothelin Receptors Following Renal Ischemia in the Rat

Wu-wong, Jinshyun, Wang, Song-Shung, Divish, Barbara, Pollock, David

Journal:

Endothelium

Année:

1994

Langue:

english

Fichier:

PDF, 530 KB

english, 1994

Vitamin D receptor (VDR) localization in human promyelocytic leukemia cells

Ruth Wu-Wong, J., Nakane, Masaki, Ma, Junli, Dixon, Doug, Gagne, Gerard

Journal:

Leukemia and Lymphoma

Année:

2006

Langue:

english

Fichier:

PDF, 328 KB

english, 2006

Dissociation Characteristics of Endothelin Receptor Agonists and Antagonists in Cloned Human Type-B Endothelin Receptor

Chiou, W. J., Magnuson, S. R., Dixon, D., Sundy, S., Opgenorth, T. J., Wu-wong, J. R.

Journal:

Endothelium

Année:

1997

Langue:

english

Fichier:

PDF, 779 KB

english, 1997

The potential for vitamin D receptor activation in cardiovascular research

Wu-Wong, Jinshyun Ruth

Journal:

Expert Opinion on Investigational Drugs

Année:

2007

Langue:

english

Fichier:

PDF, 147 KB

english, 2007

Mechanistic analysis for time-dependent effects of cinacalcet on serum calcium, phosphorus, and parathyroid hormone levels in 5/6 nephrectomized rats

Wu-Wong, J. Ruth, Nakane, Masaki, Chen, Yung-wu, Mizobuchi, Masahide

Journal:

Physiological Reports

Année:

2013

Langue:

english

Fichier:

PDF, 847 KB

english, 2013

VS-501: a novel, nonabsorbed, calcium- and aluminum-free, highly effective phosphate binder derived from natural plant polymer

Wu-Wong, J. Ruth, Chen, Yung-wu, Gaffin, Robert, Hall, Andy, Wong, Jonathan T., Xiong, Joseph, Wessale, Jerry L.

Journal:

Pharmacology Research & Perspectives

Année:

2014

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2014

Is there a need for new phosphate binders to treat phosphate imbalance associated with chronic kidney disease?

Wu-Wong, Jinshyun Ruth, Mizobuchi, Masahide

Journal:

Expert Opinion on Investigational Drugs

Année:

2014

Langue:

english

Fichier:

PDF, 522 KB

english, 2014

Vitamin D receptor agonist VS-105 improves cardiac function in the presence of enalapril in 5/6 nephrectomized rats

Wu-Wong, J. Ruth, Chen, Yung-wu, Wessale, Jerry L.

Journal:

AJP: Renal Physiology

Année:

2015

Langue:

english

Fichier:

PDF, 474 KB

english, 2015

Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption

Chiao, J W, Moonga, B S, Yang, Y M, Kancherla, R, Mittelman, A, Wu-Wong, J R, Ahmed, T

Journal:

British Journal of Cancer

Année:

2000

Langue:

english

Fichier:

PDF, 75 KB

english, 2000

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

Yin, J. J., Mohammad, K. S., Kakonen, S. M., Harris, S., Wu-Wong, J. R., Wessale, J. L., Padley, R. J., Garrett, I. R., Chirgwin, J. M., Guise, T. A.

Journal:

Proceedings of the National Academy of Sciences

Année:

2003

Langue:

english

Fichier:

PDF, 753 KB

english, 2003

Role of Phosphorus and Vitamin D Analogs in the Pathogenesis of Vascular Calcification

Wu-Wong, J. R.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2006

Langue:

english

Fichier:

PDF, 521 KB

english, 2006

Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals

Bodyak, N., Ayus, J. C., Achinger, S., Shivalingappa, V., Ke, Q., Chen, Y.-S., Rigor, D. L., Stillman, I., Tamez, H., Kroeger, P. E., Wu-Wong, R. R., Karumanchi, S. A., Thadhani, R., Kang, P. M.

Journal:

Proceedings of the National Academy of Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 740 KB

english, 2007

Endothelin Stimulates Glucose Uptake and GLUT4 Translocation via Activation of Endothelin ETA Receptor in 3T3-L1 Adipocytes

Wu-Wong, J. R., Berg, C. E., Wang, J., Chiou, W. J., Fissel, B.

Journal:

Journal of Biological Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 951 KB

english, 1999