Volume 9; Issue 7

Main
ChemMedChem
Volume 9; Issue 7

ChemMedChem

Volume 9; Issue 7

1

1-(1 H -Indol-3-yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors

Hequet, Arnaud, Burchak, Olga N., Jeanty, Matthieu, Guinchard, Xavier, Le Pihive, Emmanuelle, Maigre, Laure, Bouhours, Pascale, Schneider, Dominique, Maurin, Max, Paris, Jean-Marc, Denis, Jean-Noël, J

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 500 KB

english, 2014

2

Synthesis and Biological Evaluation of Imidazo[2,1- b ][1,3,4]thiadiazole-Linked Oxindoles as Potent Tubulin Polymerization Inhibitors

Kamal, Ahmed, Rao, M. P. Narasimha, Das, Pompi, Swapna, P., Polepalli, Sowjanya, Nimbarte, Vijaykumar D., Mullagiri, Kishore, Kovvuri, Jeshma, Jain, Nishant

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2014

3

Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins

Scott, Robert, Karki, Menuka, Reisenauer, Mary R., Rodrigues, Roberta, Dasari, Ramesh, Smith, W. Ross, Pelly, Stephen C., van Otterlo, Willem A. L., Shuster, Charles B., Rogelj, Snezna, Magedov, Igor

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2014

4

Efficient Acid-Catalyzed 18 F/ 19 F Fluoride Exchange of BODIPY Dyes

Keliher, Edmund J., Klubnick, Jenna A., Reiner, Thomas, Mazitschek, Ralph, Weissleder, Ralph

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 395 KB

english, 2014

5

Retracted: Synthesis and Cytotoxic Activity of 2-Anilinopyridine-3-Acrylamides as Tubulin Polymerization Inhibitors

Kamal, Ahmed, Ashraf, Md., Khan, M. Naseer Ahmed, Nimbarte, Vijaykumar D., Faazil, Shaikh, Subba Reddy, N. V., Taj, Shaik

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2014

6

Anti-Dengue-Virus Activity and Structure-Activity Relationship Studies of Lycorine Derivatives

Wang, Peng, Li, Lin-Feng, Wang, Qing-Yin, Shang, Lu-Qing, Shi, Pei-Yong, Yin, Zheng

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 647 KB

english, 2014

7

Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition

Matos, Maria João, Vilar, Santiago, García-Morales, Verónica, Tatonetti, Nicholas P., Uriarte, Eugenio, Santana, Lourdes, Viña, Dolores

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2014

8

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers

Meier, Samuel M., Babak, Maria V., Keppler, Bernhard K., Hartinger, Christian G.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 592 KB

english, 2014

9

3-Aminoazetidin-2-one Derivatives as N -Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration

Fiasella, Annalisa, Nuzzi, Andrea, Summa, Maria, Armirotti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertozzi, Fabio, Bandiera, Tiziano, Piomelli, Daniele

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 540 KB

english, 2014

10

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1

Tran, Thien Duc, Wakenhut, Florian, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Brimage, Rebecca A., Halstead, Rebecca,

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 613 KB

english, 2014

11

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2

Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 786 KB

english, 2014

12

Targeting Cystalysin, a Virulence Factor of Treponema denticola- Supported Periodontitis

Spyrakis, Francesca, Cellini, Barbara, Bruno, Stefano, Benedetti, Paolo, Carosati, Emanuele, Cruciani, Gabriele, Micheli, Fabrizio, Felici, Antonio, Cozzini, Pietro, Kellogg, Glen E., Voltattorni, Car

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2014

13

Computational and Experimental Insight into the Molecular Mechanism of Carboxamide Inhibitors of Succinate-Ubquinone Oxidoreductase

Zhu, Xiao-Lei, Xiong, Li, Li, Hui, Song, Xin-Ya, Liu, Jing-Jing, Yang, Guang-Fu

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2014

14

Structural Optimization and Biological Screening of a Steroidal Scaffold Possessing Cucurbitacin-Like Functionalities as B-Raf Inhibitors

Ahmed, Mahmoud S., Kopel, Lucas C., Halaweish, Fathi T.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 559 KB

english, 2014

15

Xanthones from Swertia mussotii as Multitarget-Directed Antidiabetic Agents

Zheng, Huan-Huan, Luo, Cui-Ting, Chen, Heru, Lin, Juan-Na, Ye, Chun-Ling, Mao, Shuang-Shuang, Li, Yu-Lin

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 288 KB

english, 2014

16

Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6-Diarylpyridinamines as a Novel Class of HIV-1 NNRTIS

Wu, Zhi-Yuan, Liu, Na, Qin, Bingjie, Huang, Li, Yu, Fei, Qian, Keduo, Morris-Natschke, Susan L., Jiang, Shibo, Chen, Chin Ho, Lee, Kuo-Hsiung, Xie, Lan

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 385 KB

english, 2014

17

Anticancer Potential of (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing κ P and κ P ,κ S -Coordinated Ph 2 PCH 2 CH 2 CH 2 S(O) x Ph ( x =0-2) Ligands

Ludwig, Gerd, Ranđelović, Ivan, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Bulatović, Mirna Z., Miljković, Djordje, Korb, Marcus, Lang, Heinrich, Steinborn, Dirk, Kaluđerović, Goran N.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2014

18

Development of 3-Phenyl- N -(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide Compounds as Inhibitors of Antiapoptotic Bcl-2 Family Proteins

Yang, Chengwen, Chen, Sha, Zhou, Mi, Li, Yan, Li, Yangfeng, Zhang, Zhengxi, Liu, Zhen, Ba, Qian, Li, Jingquan, Wang, Hui, Yan, Xiaomei, Ma, Dawei, Wang, Renxiao

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2014

19

Development and Screening of a Series of Antibody-Conjugated and Silica-Coated Iron Oxide Nanoparticles for Targeting the Prostate-Specific Membrane Antigen

Mukherjee, Amarnath, Darlington, Thomas, Baldwin, Richard, Holz, Charles, Olson, Sage, Kulkarni, Prakash, DeWeese, Theodore L., Getzenberg, Robert H., Ivkov, Robert, Lupold, Shawn E.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 596 KB

english, 2014

20

Design, Synthesis and Bioevaluation of an EphA2 Receptor-Based Targeted Delivery System

Barile, Elisa, Wang, Si, Das, Swadesh K., Noberini, Roberta, Dahl, Russell, Stebbins, John L., Pasquale, Elena B., Fisher, Paul B., Pellecchia, Maurizio

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 715 KB

english, 2014

21

Back Cover: The Integrin Ligand c (RGDf( N Me)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System (ChemMedChem 7/2014)

Rechenmacher, Florian, Steigerwald, Kristin, Laufer, Burkhardt, Neubauer, Stefanie, Kapp, Tobias G., Li, Liang, Mas-Moruno, Carlos, Joner, Michael, Kessler, Horst

Journal:

Année:

2014

Fichier:

PDF, 913 KB

2014

22

Cytotoxic Triosmium Carbonyl Clusters: A Structure-Activity Relationship Study

Lee, Hui Zhi Shirley, Leong, Weng Kee, Top, Siden, Vessières, Anne

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 813 KB

english, 2014

23

Bis(dipyridophenazine)(2-(2′-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) Hexafluorophosphate: A Lesson in Stubbornness

Joshi, Tanmaya, Pierroz, Vanessa, Ferrari, Stefano, Gasser, Gilles

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 836 KB

english, 2014

24

Cover Picture: Design, Synthesis and Bioevaluation of an EphA2 Receptor-Based Targeted Delivery System (ChemMedChem 7/2014)

Barile, Elisa, Wang, Si, Das, Swadesh K., Noberini, Roberta, Dahl, Russell, Stebbins, John L., Pasquale, Elena B., Fisher, Paul B., Pellecchia, Maurizio

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 758 KB

english, 2014

25

Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6 H -quinazolin-5-one Oxime

Amici, Raffaella, Bigogno, Chiara, Boggio, Roberto, Colombo, Andrea, Courtney, Stephen M., Dal Zuffo, Roberto, Dondio, Giulio, Fusar, Fulvia, Gagliardi, Stefania, Minucci, Saverio, Molteni, Marco, Mon

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 957 KB

english, 2014

26

Stereoselective Reduction of 1- O -Isopropyloxygenipin Enhances Its Neuroprotective Activity in Neuronal Cells from Apoptosis Induced by Sodium Nitroprusside

Wang, Rikang, Yang, Jian, Liao, Sufen, Xiao, Gaokeng, Luo, Jun, Zhang, Lang, Little, Peter J., Chen, Heru, Zheng, Wenhua

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 970 KB

english, 2014

27

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

Hawkins, Bill C., Lindqvist, Lisa M., Nhu, Duong, Sharp, Phillip P., Segal, David, Powell, Andrew K., Campbell, Michael, Ryan, Eileen, Chambers, Jennifer M., White, Jonathan M., Rizzacasa, Mark A., Le

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 488 KB

english, 2014

28

Spotlights on our sister journals: ChemMedChem 7/2014

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2014

29

Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase 10 A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism

Schwan, Gregor, Barbar Asskar, Ghadir, Höfgen, Norbert, Kubicova, Lenka, Funke, Uta, Egerland, Ute, Zahn, Michael, Nieber, Karen, Scheunemann, Matthias, Sträter, Norbert, Brust, Peter, Briel, Detlef

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2014

30

Graphical Abstract: ChemMedChem 7/2014

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.78 MB

english, 2014

31

The Integrin Ligand c (RGDf( N Me)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System

Rechenmacher, Florian, Steigerwald, Kristin, Laufer, Burkhardt, Neubauer, Stefanie, Kapp, Tobias G., Li, Liang, Mas-Moruno, Carlos, Joner, Michael, Kessler, Horst

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2014

32

Small-Molecule Inhibitors of AF6 PDZ-Mediated Protein-Protein Interactions

Vargas, Carolyn, Radziwill, Gerald, Krause, Gerd, Diehl, Anne, Keller, Sandro, Kamdem, Nestor, Czekelius, Constantin, Kreuchwig, Annika, Schmieder, Peter, Doyle, Declan, Moelling, Karin, Hagen, Volker

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 846 KB

english, 2014

33

Novel Heterobimetallic Radiotheranostic: Preparation, Activity, and Biodistribution

Adriaenssens, Louis, Liu, Qiang, Chaux-Picquet, Fanny, Tasan, Semra, Picquet, Michel, Denat, Franck, Le Gendre, Pierre, Marques, Fernanda, Fernandes, Célia, Mendes, Filipa, Gano, Lurdes, Campello, Mar

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 567 KB

english, 2014

34

‘À la Carte’ Peptide Shuttles: Tools to Increase Their Passage across the Blood-Brain Barrier

Malakoutikhah, Morteza, Guixer, Bernat, Arranz-Gibert, Pol, Teixidó, Meritxell, Giralt, Ernest

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 360 KB

english, 2014