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Volume 7; Issue 10

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ChemMedChem
Volume 7; Issue 10

ChemMedChem

Volume 7; Issue 10

1

Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors

Dr. Raminta Venskutonytė, Prof. Karla Frydenvang, Elena Antón Valadés, Dr. Ewa Szymańska, Prof. Tommy N. Johansen, Prof. Jette S. Kastrup, Prof. Darryl S. Pickering

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 819 KB

english, 2012

2

Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp

Sören J. Wacker, Dr. Wiktor Jurkowski, Dr. Katie J. Simmons, Prof. Dr. Colin W. G. Fishwick, Prof. Dr. A. Peter Johnson, Dr. David Madge, Prof. Dr. Erik Lindahl, Dr. Jean-Francois Rolland, Prof. Dr. B

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2012

3

Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel

Dr. Naoki Shinohara, Hiroaki Itoh, Dr. Shigeru Matsuoka, Prof. Dr. Masayuki Inoue

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2012

4

Kinase Drug Discovery. Edited by Richard A. Ward and Frederick W. Goldberg.

Prof. Richard Engh

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 170 KB

english, 2012

5

Neglected Diseases and Drug Discovery. Edited by Michael J. Palmer and Timothy N. C. Wells.

Prof. Ian Gilbert

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 160 KB

english, 2012

6

Polyamine Drug Discovery. Edited by Patrick Woster and Robert A. Casero, Jr.

Prof. Raphaël Tripier

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 199 KB

english, 2012

7

Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+-Activated K+ Channels: a Novel Target for Medicinal Chemistry Efforts?

Dr. Corina M. Balut, Dr. Kirk L. Hamilton, Prof. Daniel C. Devor

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2012

8

Ion Channel Phosphorylopathy: a Link between Genomic Variation and Human Disease

Dr. Saverio Gentile

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 989 KB

english, 2012

9

2-Aminopyridine Derivatives as Potential σ2 Receptor Antagonists

Dr. Carmen Abate, Prof. Savina Ferorelli, Dr. Mauro Niso, Dr. Cesarea Lovicario, Dr. Vittoria Infantino, Dr. Paolo Convertini, Prof. Dr. Roberto Perrone, Prof. Dr. Francesco Berardi

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 607 KB

english, 2012

10

Calcium- and Voltage-Gated Potassium (BK) Channel Activators in the 5β-Cholanic Acid-3α-ol Analogue Series with Modifications in the Lateral Chain

Dr. Anna N. Bukiya, Dr. Shivaputra A. Patil, Dr. Wei Li, Prof. Duane D. Miller, Prof. Alex M. Dopico

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 831 KB

english, 2012

11

Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

Dr. Antonio Nardi, Dr. Nils Damann, Dr. Torsten Hertrampf, Dr. Achim Kless

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 3.52 MB

english, 2012

12

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Dr. Wei-Jan Huang, Dr. Yi-Ching Wang, Shi-Wei Chao, Chen-Yui Yang, Liang-Chieh Chen, Dr. Mei-Hsiang Lin, Dr. Wen-Chi Hou, Mei-Yu Chen, Tai-Lin Lee, Ping Yang, Dr. Chung-I Chang

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 889 KB

english, 2012

13

Synthesis and Cytotoxicity of Three trans-Palladium Complexes Containing Planaramine Ligands in Human Ovarian Tumor Models

Mohammed Ehsanul Hoque Mazumder, Philip Beale, Charles Chan, Jun Qing Yu, Prof. Fazlul Huq

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 513 KB

english, 2012

14

Asymmetric 4-Aryl-1,4-dihydropyridines Potentiate Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Dr. Michele Giampieri, Dr. Nicolas Vanthuyne, Dr. Erika Nieddu, Dr. Marco T. Mazzei, Dr. Maria Anzaldi, Dr. Nicoletta Pedemonte, Dr. Luis J. V. Galietta, Prof. Christian Roussel, Prof. Mauro Mazzei

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 396 KB

english, 2012

15

Structure–Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family

Subhrangsu Roy, Adebola Morayo Akande, Roddy J. Large, Tim I. Webb, Costin Camarasu, Gerard P. Sergeant, Noel G. McHale, Keith D. Thornbury, Mark A. Hollywood

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 819 KB

english, 2012

16

Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)

Dr. Francesca Aiello, Yumna Shabaik, Adrian Esqueda, Tino W. Sanchez, Dr. Fedora Grande, Prof. Antonio Garofalo, Prof. Nouri Neamati

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2012

17

Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Co-transport Inhibitor S0859: in vitro Efficacy Studies in Breast Cancer Cells

Ann M. Larsen, Dr. Niels Krogsgaard-Larsen, Gitte Lauritzen, Christina W. Olesen, Prof. Steen Honoré Hansen, Dr. Ebbe Boedtkjer, Prof. Stine F. Pedersen, Prof. Lennart Bunch

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 610 KB

english, 2012

18

Drug Delivery in Oncology. Edited by Felix Kratz, Peter Senter and Henning Steinhagen.

Prof. Rosa María Olmo López

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 176 KB

english, 2012

19

Editorial: Channeling Drug Discovery

Dr. Henning Steinhagen, Dr. Nils Damann

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 607 KB

english, 2012

20

Cover Picture: Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp (ChemMedChem 10/2012)

Sören J. Wacker, Dr. Wiktor Jurkowski, Dr. Katie J. Simmons, Prof. Dr. Colin W. G. Fishwick, Prof. Dr. A. Peter Johnson, Dr. David Madge, Prof. Dr. Erik Lindahl, Dr. Jean-Francois Rolland, Prof. Dr. B

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 729 KB

english, 2012

21

Inside Cover: Structure–Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family (ChemMedChem 10/2012)

Subhrangsu Roy, Adebola Morayo Akande, Roddy J. Large, Tim I. Webb, Costin Camarasu, Gerard P. Sergeant, Noel G. McHale, Keith D. Thornbury, Mark A. Hollywood

Journal:

Année:

2012

Fichier:

PDF, 1.35 MB

2012

22

Graphical Abstract: ChemMedChem 10/2012

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2012

23

Spotlights on our sister journals: ChemMedChem 10/2012

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2012

24

Preview: ChemMedChem 11/2012

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 78 KB

english, 2012

25

Back Cover: Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel (ChemMedChem 10/2012)

Dr. Naoki Shinohara, Hiroaki Itoh, Dr. Shigeru Matsuoka, Prof. Dr. Masayuki Inoue

Journal:

Année:

2012

Fichier:

PDF, 1.10 MB

2012