Joseph K. Krushinski : rechercher sur Z-Library

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1

Indoloxypropanolamine analogues as 5-HT1A receptor antagonists

Joseph H. Krushinski Jr., John M. Schaus, Dennis C. Thompson, David O. Calligaro, David L. Nelson, Susan H. Luecke, David B. Wainscott, David T. Wong

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 170 KB

english, 2007

2

Safety and Efficiency of Intravenous Push Lacosamide Administration

Davidson, K. Erin, Newell, Joshua, Alsherbini, Khalid, Krushinski, Joseph, Jones, G. Morgan

Journal:

Neurocritical Care

Année:

2018

Langue:

english

Fichier:

PDF, 698 KB

english, 2018

3

Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl)benzamide (PipISB), with carbon-11 or fluorine-18

Sean R. Donohue, Christer Halldin, Magnus Schou, Jinsoo Hong, Lee Phebus, Eyassu Chernet, Stephen A. Hitchcock, Kevin M. Gardinier, Kevin M. Ruley, Joseph H. Krushinski, John Schaus, Victor W. Pike

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 216 KB

english, 2008

4

Preparation of 14C- and 18O-labeled 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]-pyridine hydrochloride (LY175326), a cardiotonic with inotropic and vasodilator activities

Don Kau, Joseph H. Krushinski, David W. Robertson

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1985

Langue:

english

Fichier:

PDF, 605 KB

english, 1985

5

Synthesis of 14C- and 2H-labeled 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one (LY195115), an orally effective positive inotrope

David W. Robertson, Joseph H. Krushinski, Don Kau

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1986

Langue:

english

Fichier:

PDF, 437 KB

english, 1986

6

Synthesis of 14C- and 3H-labeled fluoxetine, a selective serotonin uptake inhibitor

David W. Robertson, Joseph H. Krushinski, David T. Wong, Don Kau

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1987

Langue:

english

Fichier:

PDF, 386 KB

english, 1987

7

Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists

Deyi Zhang, Dan Kohlman, Joseph Krushinski, Sidney Liang, Bai-Ping Ying, John E. Reilly, Sean R. Dinn, David B. Wainscott, Suzanne Nutter, Wendy Gough, David L.G. Nelson, John M. Schaus, Yao-Chang Xu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 322 KB

english, 2004

8

[3H]LY334370, a novel radioligand for the 5-HT1Freceptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain

Virginia L. Lucaites, Joseph H. Krushinski, John M. Schaus, James E. Audia, David L. Nelson

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 1.93 MB

english, 2005

9

[3H]LY334370, a novel radioligand for the 5-HT1Freceptor. I. In vitro characterization of binding properties

David B. Wainscott, Joseph H. Krushinski, James E. Audia, John M. Schaus, John M. Zgombick, Virginia L. Lucaites, David L. Nelson

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 247 KB

english, 2005

10

Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine

Robertson, David W., Beedle, E. E., Krushinski, Joseph H., Pollock, G. Don, Wilson, Harve, Wyss, Virginia L., Hayes, J. Scott

Journal:

Journal of Medicinal Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 1.41 MB

english, 1985

11

Pharmacological characterization of the cannabinoid CB1 receptor PET ligand ortholog, [3H]MePPEP

Todd M. Suter, Amy K. Chesterfield, Chun Bao, John M. Schaus, Joseph H. Krushinski, Michael A. Statnick, Christian C. Felder

Journal:

European Journal of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 869 KB

english, 2010

12

Synthesis, Ex Vivo Evaluation, and Radiolabeling of Potent 1,5-Diphenylpyrrolidin-2-one Cannabinoid Subtype-1 Receptor Ligands as Candidates for In Vivo Imaging

Donohue, Sean R., Krushinski, Joseph H., Pike, Victor W., Chernet, Eyassu, Phebus, Lee, Chesterfield, Amy K., Felder, Christian C., Halldin, Christer, Schaus, John M.

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 266 KB

english, 2008

13

Localization of ATP sensitive potassium channels in the rat brain using a novel radioligand, [125I]iodoglibenclamide

Donald R. Gehlert, Dale E. Mais, Susan L. Gackenheimer, Joseph H. Krushinski, David W. Robertson

Journal:

European Journal of Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 349 KB

english, 1990

14

Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol

Robertson, David W., Krushinski, Joseph H., Beedle, E. E., Leander, J. David, Wong, David T., Rathbun, R. C.

Journal:

Journal of Medicinal Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 1.34 MB

english, 1986

15

LY227942, an inhibitor of serotonin and norepinephrine uptake: Biochemical pharmacology of a potential antidepressant drug

David T. Wong, David W. Robertson, Frank P. Bymaster, Joseph K. Krushinski, Leroy R. Reid

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 432 KB

english, 1988

16

Persistent depletion of striatal dopamine and cortical norepinephrine in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol (MPTP-3-OL), an analog of MPTP

Susan K. Hemrick-Luecke, David W. Robertson, Joseph H. Krushinski Jr., Ray W. Fuller

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 497 KB

english, 1992

17

(R)-thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake

Donald R. Gehlert, Susan K. Hemrick-Luecke, Douglas A. Schober, Joseph Krushinski, J.Jeffry Howbert, David W. Robertson, David T. Wong, Ray W. Fuller

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 540 KB

english, 1995

18

Dihydropyridazinone cardiotonics. The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one

Robertson, David W., Krushinski, Joseph H., Beedle, E. E., Wyss, V., Pollock, G. Don, Wilson, Harve, Kauffman, Raymond F., Hayes, J. Scott

Journal:

Journal of Medicinal Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 1.21 MB

english, 1986

19

The absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor

Robertson, David W., Krushinski, Joseph H., Fuller, Ray W., Leander, J. David

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 918 KB

english, 1988

20

LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

Wong, David T., Bymaster, Frank P., Mayle, Douglas A., Reid, Leroy R., Krushinski, Joseph H., Robertson, David W.

Journal:

Neuropsychopharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 689 KB

english, 1993

21

Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain

Wong, David T., Bymaster, Frank P., Reid, Leroy R., Mayle, Douglas A., Krushinski, Joseph H., Robertson, David W.

Journal:

Neuropsychopharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 615 KB

english, 1993

22

Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-spiro[cycloalkane-1,3'-[3H]indol]-2'(1'H)-ones

Robertson, David W., Krushinski, Joseph H., Pollock, G. Don, Wilson, Harve, Kauffman, Raymond F., Hayes, J. Scott

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 867 KB

english, 1987

23

Characterization of type I 5α-reductase activity in DU145 human prostatic adenocarcinoma cells

Kaefer, Martin, Audia, James E., Bruchovsky, Nicholas, Goode, Robin L., Hsiao, Kenneth C., Leibovitch, Ilan Y., Krushinski, Joseph H., Lee, Chung, Steidle, Christopher P., Sutkowski, Debra M., Neubaue

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

1996

Langue:

english

Fichier:

PDF, 926 KB

english, 1996

24

Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant

Robertson, David W., Beedle, E. E., Krushinski, Joseph H., Lawson, Ronald R., Parli, C. John, Potts, Brian, Leander, J. David

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 581 KB

english, 1991

25

Expedient synthesis and biochemical properties of an [125I]-labeled analogue of glyburide, a radioligand for ATP-inhibited potassium channels

Robertson, David W., Schober, Douglas A., Krushinski, Joseph H., Mais, Dale E., Thompson, Dennis C., Gehlert, Donald R.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 426 KB

english, 1990

26

Synthesis of a tritium-labeled indolidan analog and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites

Robertson, David W., Krushinski, Joseph H., Utterback, Barbara G., Kauffman, Raymond F.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 709 KB

english, 1989

27

3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists

Hipskind, Philip A., Howbert, J. Jeffry, Bruns, Robert F., Cho, Steven S. Y., Crowell, Thomas A., Foreman, Mark M., Gehlert, Donald R., Iyengar, Smriti, Johnson, Kirk W., Krushinski, Joseph H., Li, Do

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 388 KB

english, 1996

28

]PYRIDINE, A POTENT NONGLYCOSIDE INHIBITOR OF Na + , K + -ATPASE

Robertson, David W., Krushinski, Joseph H.

Journal:

Organic Preparations and Procedures International

Année:

1988

Langue:

english

Fichier:

PDF, 245 KB

english, 1988

29

Imidazole-pyridine bioisosterism: comparison of the inotropic activities of pyridine- and imidazole-substituted 6-phenyldihydropyridazinone cardiotonics

Robertson, David W., Krushinski, Joseph H., Pollock, G. Don, Hayes, J. Scott

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 640 KB

english, 1988

30

Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase

Robertson, David W., Jones, Noel D., Krushinski, Joseph H., Pollock, G. Don, Swartzendruber, John K., Hayes, J. Scott

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 708 KB

english, 1987

31

The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Yasuno, Fumihiko, Brown, Amira K, Zoghbi, Sami S, Krushinski, Joseph H, Chernet, Eyassu, Tauscher, Johannes, Schaus, John M, Phebus, Lee A, Chesterfield, Amy K, Felder, Christian C, Gladding, Robert L

Journal:

Neuropsychopharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 323 KB

english, 2008

32

Synthesis of Homochiral 2-(2-Arylethyl)piperazines

Schaus, John, Krushinski, Joseph, Ruley, Kevin, Rocco, Vincent

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 111 KB

english, 2007

33

Synthesis and Pharmacological Characterization of 2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a potent, subtype selective, and orally available positive allosteric modulator of the human dopamine D1 receptor

Hao, Junliang, Beck, James P, Schaus, Johm M, Krushinski, Joseph H, Chen, Qi, Beadle, Christopher D, Vidal, Paloma, Reinhard, Matthew R, Dressman, Bruce A, Massey, Steven M, Boulet, Serge L, Cohen, Mi

Journal:

Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2019

34

756

Davidson, K. Erin, Newell, Joshua, Alsherbini, Khalid, Krushinski, Joseph, Jones, G. Morgan

Journal:

Critical Care Medicine

Année:

2018

Fichier:

PDF, 48 KB

2018