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1

Complement System Part II: Role in Immunity

Merle, Nicolas S., Noe, Remi, Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.

Journal:

Frontiers in Immunology

Année:

2015

Langue:

english

Fichier:

PDF, 20.29 MB

english, 2015

2

Microparticules circulantes provenant des polynucléaires chez les dialysés

Daniel, L., Joly, D., Lesavre, P., Halbwachs-Mecarelli, L.

Journal:

Annales de Pathologie

Année:

2004

Langue:

french

Fichier:

PDF, 54 KB

french, 2004

3

ADHESION MOLECULES IN HUMAN CRESCENTIC GLOMERULONEPHRITIS

PATEY, N., LESAVRE, P., HALBWACHS-MECARELLI, L., NOËL, L. H.

Journal:

The Journal of Pathology

Année:

1996

Langue:

english

Fichier:

PDF, 791 KB

english, 1996

4

Redox regulation of β2-integrin CD11b / CD18 activation

Eric Blouin, Lise Halbwachs-Mecarelli, Philippe Rieu

Journal:

European Journal of Immunology

Année:

1999

Langue:

english

Fichier:

PDF, 299 KB

english, 1999

5

Inhibition of alternative pathway factor D by factor B -related synthetic hexapeptides

Philippe Lesavre, Marie-Hélène Guillard, Lise Halbwachs-Mecarelli

Journal:

European Journal of Immunology

Année:

1982

Langue:

english

Fichier:

PDF, 380 KB

english, 1982

6

Modulation of neutrophil expression of C3b receptors (CR1) by soluble monomeric human C3b

Françoise Porteu, Amparo Mir, Lise Halbwachs-Mecarelli

Journal:

European Journal of Immunology

Année:

1987

Langue:

english

Fichier:

PDF, 694 KB

english, 1987

7

Complement alternative pathway activation and control on membranes of human lymphoid B cell lines

Valérie Caudwell, FrançOise Porteu, Alain Calender, Michael K. Pangburn, Lise Halbwachs-Mecarelli

Journal:

European Journal of Immunology

Année:

1990

Langue:

english

Fichier:

PDF, 824 KB

english, 1990

8

Human neutrophils release their major membrane sialoprotein, leukosialin (CD43), during cell activation

Philippe Rieu, Françoise Porteu, Gilles Bessou, Philippe Lesavre, Lise Halbwachs-Mecarelli

Journal:

European Journal of Immunology

Année:

1992

Langue:

english

Fichier:

PDF, 680 KB

english, 1992

9

L'activation du polynucléaire neutrophile dans la synovite rhumatoïde

Marie-Anne Gougerot-Pocidalo, Lise Halbwachs-Mecarelli

Journal:

Revue du Rhumatisme

Année:

2005

Langue:

french

Fichier:

PDF, 133 KB

french, 2005

10

Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis

L. HALBWACHS-MECARELLI, P. NUSBAUM, L. H. NOËL, D. REUMAUX, S. ERLINGER, J. P. GRÜNFELD, P. LESAVRE

Journal:

Clinical & Experimental Immunology

Année:

1992

Langue:

english

Fichier:

PDF, 2.08 MB

english, 1992

11

Neutrophil expression of tumour necrosis factor receptors (TNF-R) and of activation markers (CD11b, CD43, CD63) in rheumatoid arthritis

S. LOPEZ, L. HALBWACHS-MECARELLI, P. RAVAUD, G. BESSOU, M. DOUGADOS, F. PORTEU

Journal:

Clinical & Experimental Immunology

Année:

1995

Langue:

english

Fichier:

PDF, 3.37 MB

english, 1995

12

Charge and size of mesangial IgA in IgA nephropathy

Monteiro, Renato C, Halbwachs-Mecarelli, Lise, Roque-Barreira, Maria Cristina, Noel, Laure-Hélène, Berger, Jean, Lesavre, Philippe

Journal:

Kidney International

Année:

1985

Langue:

english

Fichier:

PDF, 583 KB

english, 1985

13

Isotype and affinity of anti-myeloperoxidase autoantibodies in systemic vasculitis

Kokolina, Elisabeth, Noël, Laure-Hélène, Nusbaum, Patrick, Geffriaud, Christine, Grünfeld, Jean-Pierre, Halbwachs-Mecarelli, Lise, Lesavre, Philippe

Journal:

Kidney International

Année:

1994

Langue:

english

Fichier:

PDF, 677 KB

english, 1994

14

Role of αv integrins in mesangial cell adhesion to vitronectin and von Willebrand factor

Hafdi, Zakia, Lesavre, Philippe, Tharaux, Pierre Louis, Bessou, Gilles, Baruch, Dominique, Halbwachs-Mecarelli, Lise

Journal:

Kidney International

Année:

1997

Langue:

english

Fichier:

PDF, 836 KB

english, 1997

15

Neutrophils: Molecules, Functions and Pathophysiological Aspects

Witko-Sarsat, Véronique, Rieu, Philippe, Descamps-Latscha, Béatrice, Lesavre, Philippe, Halbwachs-Mecarelli, Lise

Journal:

Laboratory Investigation

Année:

2000

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2000

16

Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis

Daniel, L, Fakhouri, F, Joly, D, Mouthon, L, Nusbaum, P, Grunfeld, J-P, Schifferli, J, Guillevin, L, Lesavre, P, Halbwachs-Mecarelli, L

Journal:

Kidney International

Année:

2006

Langue:

english

Fichier:

PDF, 241 KB

english, 2006

17

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

Roumenina, L. T., Sene, D., Radanova, M., Blouin, J., Halbwachs-Mecarelli, L., Dragon-Durey, M.-A., Fridman, W. H., Fremeaux-Bacchi, V.

Journal:

The Journal of Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 920 KB

english, 2011

18

Alternative complement pathway assessment in patients with atypical HUS

Lubka T. Roumenina, Chantal Loirat, Marie-Agnes Dragon-Durey, Lise Halbwachs-Mecarelli, Catherine Sautes-Fridman, Veronique Fremeaux-Bacchi

Journal:

Journal of Immunological Methods

Année:

2011

Langue:

english

Fichier:

PDF, 994 KB

english, 2011

19

Factor H protects stressed but not quiescent glomerular endothelial cells from complement-mediated damage

Lubka T. Roumenina, Marie Frimat, Caroline Poitou, Michal Malina, Sylvain Bigot, Marie-Agnès Dragon-Durey, Simon C. Satchell, Peter W. Mathieson, Lise Halbwachs-Mecarelli, Veronique Fremeaux-Bacchi

Journal:

Molecular Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 73 KB

english, 2010

20

Structure-Function-Disease map for the genetic abnormalities in the central complement component C3

L.T. Roumenina, L. Halbwachs-Mecarelli, P. Bordereau, T. Rybkine, M.A. Dragon-Durey, M. Noris, C. Sautes-Fridman, V. Frémeaux-Bacchi

Journal:

Molecular Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 64 KB

english, 2011

21

Molecular characterization and clinical history of a homozygous functional C1q abnormality

L.T. Roumenina, D. Sène, M. Radanova, J. Blouin, L. Halbwachs-Mecarelli, M.A. Dragon-Durey, W. Fridman, V. Frémeaux-Bacchi

Journal:

Molecular Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 63 KB

english, 2011

22

Three novel C3 mutations in atypical haemolytic uraemic syndrome: Two ways to hyperactive C3 convertase

M.M. Malina, R.L. Roumenina, B.P. Bordereau, S.C.P. Schmitt, M.A.M. Majid, J.A. Jankauskiene, S.T. Seeman, H.-M.L. Halbwachs-Mecarelli, F.-B.V. Fremeaux-Bacchi, S.F. Schaefer

Journal:

Molecular Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 71 KB

english, 2011

23

Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes.

A Dehghani Zadeh, S Seveau, L Halbwachs-Mecarelli, H.U Keller

Journal:

Biology of the Cell

Année:

2003

Langue:

english

Fichier:

PDF, 368 KB

english, 2003

24

Atypical Autoantigen Targets of Perinuclear Antineutrophil Cytoplasm Antibodies (P-ANCA): Specificity and Clinical Associations

P. Lesavre, L.H. Noël, S. Gayno, P. Nusbaum, D. Reumaux, S. Erlinger, J.P. Grünfeld, L. Halbwachs-Mecarelli

Journal:

Journal of Autoimmunity

Année:

1993

Fichier:

PDF, 490 KB

1993

25

Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool

L. Halbwachs-Mecarelli, G. Bessou, P. Lesavre, S. Lopez, V. Witko-Sarsat

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 508 KB

english, 1995

26

Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies

Véronique Witko-Sarsat, Lise Halbwachs-Mecarelli, Roque P. Almeida, Patrick Nusbaum, Maxine Melchior, Ghassan Jamaleddine, Philippe Lesavre, Béatrice Descamps-Latscha, Joëlle E. Gabay

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1996

27

Neutrophiles dans l’hypersensibilité

L. Halbwachs-Mecarelli

Journal:

Revue Française d'Allergologie et d'Immunologie Clinique

Année:

2005

Langue:

french

Fichier:

PDF, 163 KB

french, 2005

28

The macrophage-derived neutrophil chemotactic factor, MNCF: A lectin with TNF-α-like activities on neutrophils

Karina Alves Toledo, Fernando Lourenço Pereira, Agnès Mambole, Philippe Lesavre, Maria Cristina Roque-Barreira, Lise Halbwachs-Mecarelli

Journal:

Biochemical and Biophysical Research Communications

Année:

2008

Langue:

english

Fichier:

PDF, 467 KB

english, 2008

29

Implication of haeme in the complement alternative pathway-mediated endothelial damage in atypical haemolytic uraemic syndrome

Lubka Roumenina, Laurent Camous, Lise Halbwachs-Mecarelli, Marie-Agnes Dragon-Durey, Catherine Sautes-Fridman, Veronique Frémeaux-Bacchi

Journal:

Molecular Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 70 KB

english, 2008

30

Complement activation by cytokine-activated neutrophils in the context of Anti-Neutrophil-Cytoplasm Autoantibodies vasculitis

M. Frimat, L. Camous, L. Roumenina, S. Bigot, P. Lesavre, V. Fremeaux-Bacchi, L. Halbwachs-Mecarelli

Journal:

Molecular Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 79 KB

english, 2009

31

Complement activation by endothelial cells treated with inflammatory cytokines or heme, in the context of atypical hemolytic uremic syndrome

Marie Frimat, Lubka Roumenina, Laurent Camous, Sylvain Bigot, Philippe Lesavre, Simon C. Satchell, Peter W. Mathieson, Véronique Frémeaux-Bacchi, Lise Halbwachs-Mecarelli

Journal:

Molecular Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 72 KB

english, 2009

32

Further evidence for a paradoxical role of the alternative pathway C3 convertase in atypical haemolytic Uremic Syndrome

Lubka Roumenina, Mathieu Cayla, Christophe Hue, Sylvain Bigot, Simon Satchell, Peter Mathieson, Chantal Loirat, Catherine Sautes-Fridman, Marie-Agnes Dragon-Durey, Lise Halbwachs-Mecarelli, Veronique

Journal:

Molecular Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 67 KB

english, 2009

33

Factor H mutations in SCR1–4 and SCR6–9 are equally important genetic susceptibility factors for atypical Haemolytic Uraemic Syndrome as the mutations in SCR19–20

Lubka Roumenina, Marie Frimat, Fadi Fakhouri, Chantal Loirat, Sylvain Bigot, Catherine Sautes-Fridman, Lise Halbwachs-Mecarelli, Véronique Frémeaux-Bacchi

Journal:

Molecular Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 67 KB

english, 2009

34

Novel C3 convertase gain of function in atypical haemolytic uraemic syndrome, caused by a frequent mutation in C3

Lubka T. Roumenina, Marie Frimat, Christophe Hue, Sophie Chauvet, Sylvain Bigot, Simon C. Satchell, Peter W. Mathieson, Catherine Sautes–Fridman, John Atkinson, Lise Halbwachs-Mecarelli, Arnaud Lionet

Journal:

Molecular Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 73 KB

english, 2010

35

A study of 46 atypical HUS mutations reveals that C3 and factor H mutations mirror each other on protein surfaces, engaged in the C3b–FH complex

Lubka T. Roumenina, Tania Rybkine, Morgane Mignotet, Satu Hyvärinen, Christophe Hue, Marina Noris, Sakari Jokiranta, Marie-Agnes Dragon-Durey, Lise Halbwachs-Mecarelli, Veronique Fremeaux-Bacchi

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 70 KB

english, 2012

36

Membrane cofactor protein (MCP) haplotype, which predisposes to atypical hemolytic and uremic syndrome, has no consequence on neutrophils and endothelial cells MCP levels or on HUVECs ability to activate complement

Marie frimat, Lubka T. Roumenina, Fanny Tabarin, Lise Halbwachs-Mecarelli, Veronique Fremeaux-Bacchi

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 86 KB

english, 2012

37

Large spectrum of Factor B aHUS mutations functional consequences on the C3 convertase – From gain to lack of functional consequence

Lubka T. Roumenina, Laura Vergoz, Tania Rybkine, Roberta Donadelli, Mathieu Cayla, Richard Smith, Marina Noris, Lise Halbwachs-Mecarelli, Veronique Fremeaux-Bacchi

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 81 KB

english, 2012

38

Towards a new model for the C1q – Calreticulin interaction at the phagocytic synapse

Sothea Touch, Jordan D. Dimitrov, Anne Chouquet, Lise Halbwachs-Mecarelli, Philippe Frachet, Veronique Fremeaux-Bacchi, Christine Gaboriaud, Lubka T. Roumenina

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 89 KB

english, 2012

39

A prevalent CFHR1/FH reverse hybrid gene in aHUS patients induces deregulation of the alternative pathway

Roumenina, L., Strain, L., Deury, D., Merle, N., Halbwachs-Mecarelli, L., Goodship, T., Fremeaux-Bacchi, V.

Journal:

Molecular Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 64 KB

english, 2013

40

Von Willebrand Factor interacts with Factor H and enhances its cofactor activity

Rayes, J., Roumenina, L., Repressé, Y., Dimitrov, J., Ing, M., Delignat, S., Halbwachs-Mecarelli, L., Borel-Derlon, A., Kaveri, S., Frémaux-Bacchi, V., Lacroix-Desmazes, S.

Journal:

Molecular Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 63 KB

english, 2013

41

Albumin Inhibits Neutrophil Spreading and Hydrogen Peroxide Release by Blocking the Shedding of CD43 (Sialophorin, Leukosialin)

Carl Nathan, Qiao-wen Xie, Lise Halbwachs-Mecarelli and Jin

Journal:

The Journal of Cell Biology

Année:

1993

Langue:

english

Fichier:

PDF, 3.56 MB

english, 1993

42

Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome

Canaud, Guillaume, Bienaimé, Frank, Tabarin, Fanny, Bataillon, Guillaume, Seilhean, Danielle, Noël, Laure-Hélène, Dragon-Durey, Marie-Agnès, Snanoudj, Renaud, Friedlander, Gérard, Halbwachs-Mecarelli,

Journal:

New England Journal of Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 798 KB

english, 2014

43

CD43 (Sialophorin, Leukosialin) Shedding is an Initial Event During Neutrophil Migration, which Could be Closely Related to the Spreading of Adherent Cells

Lopez, S., Seveau, S., Lesavre, P., Robinson, M. K., Halbwachs-Mecarelli, L.

Journal:

Cell Communication and Adhesion

Année:

1998

Langue:

english

Fichier:

PDF, 827 KB

english, 1998

44

Distinct Signaling Pathways Are Involved in Leukosialin (CD43) Down-regulation, Membrane Blebbing, and Phospholipid Scrambling during Neutrophil Apoptosis

Nusbaum, P., Laine, C., Bouaouina, M., Seveau, S., Cramer, E. M., Masse, J. M., Lesavre, P., Halbwachs-Mecarelli, L.

Journal:

Journal of Biological Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2005

45

Distribution of Integrin Subunits in Normal Human Kidney

Patey, N., Halbwachs-Mecarelli, L., Droz, D., Lesavre, P., Noel, L. H.

Journal:

Cell Communication and Adhesion

Année:

1994

Langue:

english

Fichier:

PDF, 2.22 MB

english, 1994

46

Increased Membrane Expression of Proteinase 3 during Neutrophil Adhesion in the Presence of Anti Proteinase 3 Antibodies

Brachemi, S., Mambole, A., Fakhouri, F., Mouthon, L., Guillevin, L., Lesavre, P., Halbwachs-Mecarelli, L.

Journal:

Journal of the American Society of Nephrology

Année:

2007

Langue:

english

Fichier:

PDF, 419 KB

english, 2007

47

The Cleavage of Neutrophil Leukosialin (CD43) by Cathepsin G Releases Its Extracellular Domain and Triggers Its Intramembrane Proteolysis by Presenilin/ -Secretase

Mambole, A., Baruch, D., Nusbaum, P., Bigot, S., Suzuki, M., Lesavre, P., Fukuda, M., Halbwachs-Mecarelli, L.

Journal:

Journal of Biological Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 923 KB

english, 2008

48

Long-Term Reversal of Established Autoimmunity upon Transient Blockade of the LFA-1/Intercellular Adhesion Molecule-1 Pathway

Bertry-Coussot, L., Lucas, B., Danel, C., Halbwachs-Mecarelli, L., Bach, J.-F., Chatenoud, L., Lemarchand, P.

Journal:

The Journal of Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 700 KB

english, 2002

49

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome--Disease-Relevant or Benign?

Marinozzi, M. C., Vergoz, L., Rybkine, T., Ngo, S., Bettoni, S., Pashov, A., Cayla, M., Tabarin, F., Jablonski, M., Hue, C., Smith, R. J., Noris, M., Halbwachs-Mecarelli, L., Donadelli, R., Fremeaux-B

Journal:

Journal of the American Society of Nephrology

Année:

2014

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2014

50

TNF-Induced 2 Integrin Activation Involves Src Kinases and a Redox-Regulated Activation of p38 MAPK

Bouaouina, M., Blouin, E., Halbwachs-Mecarelli, L., Lesavre, P., Rieu, P.

Journal:

The Journal of Immunology

Année:

2004

Langue:

english

Fichier:

PDF, 757 KB

english, 2004