Eigenbrot, : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (172)
Les plus populaires
Liste
- Liste
- Tableau

1

Phage-displayed Antibody Libraries of Synthetic Heavy Chain Complementarity Determining Regions

Sachdev S. Sidhu, Bing Li, Yvonne Chen, Frederic A. Fellouse, Charles Eigenbrot, Germaine Fuh

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 853 KB

english, 2004

2

X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: Structural indications of the key role of VH residues 59 to 65

Dr. Charles Eigenbrot, Tania Gonzalez, Julia Mayeda, Paul Carter, Winifred Werther, Timothy Hotaling, Judy Fox, Jeremy Kessler

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

1994

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1994

3

The Factor VII Zymogen Structure Reveals Reregistration of β Strands during Activation

Charles Eigenbrot, Daniel Kirchhofer, Mark S. Dennis, Lydia Santell, Robert A. Lazarus, Jennifer Stamos, Mark H. Ultsch

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 443 KB

english, 2001

4

X-ray structure of human relaxin at 1·5Å: Comparison to insulin and implications for receptor binding determinants

Charles Eigenbrot, Michael Randal, Clifford Quan, John Burnier, Lori O'Connell, Ernst Rinderknecht, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Année:

1991

Langue:

english

Fichier:

PDF, 707 KB

english, 1991

5

Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library

Wei-Ching Liang, Mark S. Dennis, Scott Stawicki, Yvan Chanthery, Qi Pan, Yongmei Chen, Charles Eigenbrot, JianPing Yin, Alexander W. Koch, Xiumin Wu, Napoleone Ferrara, Anil Bagri, Marc Tessier-Lavign

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2007

6

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)

MacKinnon, Colin H., Lau, Kevin, Burch, Jason D., Chen, Yuan, Dines, Jonathon, Ding, Xiao, Eigenbrot, Charles, Heifetz, Alexander, Jaochico, Allan, Johnson, Adam, Kraemer, Joachim, Kruger, Susanne, Kr

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2013

7

Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies †

Wakankar, Aditya A., Borchardt, Ronald T., Eigenbrot, Charles, Shia, Steven, Wang, Y. John, Shire, Steve J., Liu, Jun L.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 277 KB

english, 2007

8

Inhibitors of Tissue Factor • Factor VIIa for Anticoagulant Therapy

Lazarus, Robert, Olivero, Alan, Eigenbrot, Charles, Kirchhofer, Daniel

Journal:

Current Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 296 KB

english, 2004

9

Battling Btk Mutants With Non-Covalent Inhibitors That Overcome Cys481 and Thr474 Mutations

Johnson, Adam R., Kohli, Pawan Bir, Katewa, Arna, Gogol, Emily, Belmont, Lisa D., Choy, Regina, Penuel, Elicia, Burton, Luciana, Eigenbrot, Charles, Yu, Christine, Ortwine, Daniel Fred, Bowman, Krista

Journal:

ACS Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2016

10

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Drug-like Properties

Wang, Xiaojing, Barbosa, James, Blomgren, Peter, Bremer, Meira C., Chen, Jacob, Crawford, James J., Deng, Wei, Dong, Liming, Eigenbrot, Charles, Gallion, Steve, Hau, Jonathan, Hu, Huiyong, Johnston, A

Journal:

ACS Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 731 KB

english, 2017

11

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Liang, Jun, Van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade S., Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Goodacre, Simo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2017

12

Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

Crawford, James J., Johnson, Adam R., Misner, Dinah L., Belmont, Lisa D., Castanedo, Georgette M., Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, H

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2018

13

Stereochemical differences in fluorocyclopropyl amides enable tuning of Btk inhibition and off-target activity

Crawford, James J., Lee, Wendy, Johnson, Adam R., Delatorre, Kelly J, Chen, Jacob, Eigenbrot, Charles, Heidmann, Julia, Kakiuchi-Kiyota, Satoko, Katewa, Arna, Kiefer, James R., Liu, Lichuan, Lubach, J

Journal:

ACS Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 779 KB

2020

14

Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of e38C/C50A IL-8 at 2 Å resolution

Charles Eigenbrot, Henry B. Lowman, Linda Chee, Dean R. Artis

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

1997

Langue:

english

Fichier:

PDF, 163 KB

english, 1997

15

Receptor-binding conformation of the “ELR” motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 Å resolution

Nancy Gerber, Henry Lowman, Dean R. Artis, Charles Eigenbrot

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2000

Langue:

english

Fichier:

PDF, 497 KB

english, 2000

16

Laser-induced fluorescence spectroscopy of jet-cooled phenylcarbazole and a weakly bonded carbazole—benzene complex

Haiping Yu, Sharifuddin M. Zain, Ilya V. Eigenbrot, David Phillips

Journal:

Chemical Physics Letters

Année:

1993

Langue:

english

Fichier:

PDF, 609 KB

english, 1993

17

Structural consequences of mutation

Charles Eigenbrot, Anthony A. Kossiakoff

Journal:

Current Opinion in Biotechnology

Année:

1992

Langue:

english

Fichier:

PDF, 580 KB

english, 1992

18

Investigation of carbazole derivatives and their van der Waals complexes in the jet by laser-induced fluorescence spectroscopy

Haiping Yu, Sharifuddin M. Zain, Ilya V. Eigenbrot, David Phillips

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 908 KB

english, 1994

19

Rearrangement of N-hydroxy β-lactams

Atanu Biswas, Charles Eigenbrot, Marvin J. Miller

Journal:

Année:

1986

Langue:

english

Fichier:

PDF, 517 KB

english, 1986

20

The synthesis and characterization of (UCp3)2 (pyrazine) and [U(MeCp)3]2(pyrazine): π-bridged dimers of U3+

Charles W. Eigenbrot Jr., Kenneth N. Raymond

Journal:

Année:

1982

Langue:

english

Fichier:

PDF, 251 KB

english, 1982

21

The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether

Ping Liu, Samuel Bouyain, Charles Eigenbrot, Daniel J. Leahy

Journal:

Protein Science

Année:

2012

Langue:

english

Fichier:

PDF, 226 KB

english, 2012

22

Structural effects induced by mutagenesis affected by crystal packing factors: The structure of a 30–51 disulfide mutant of basic pancreatic trypsin inhibitor

Charles Eigenbrot, Michael Randal, Anthony A. Kossiakoff

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

1992

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1992

23

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)

Charles Eigenbrot, Rajkumar Ganesan, Daniel Kirchhofer

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 450 KB

english, 2010

24

Peptide exosite inhibitors of factor VIIa as anticoagulants

Dennis, Mark S., Eigenbrot, Charles, Skelton, Nicholas J., Ultsch, Mark H., Santell, Lydia, Dwyer, Mary A., O'Connell, Mark P., Lazarus, Robert A.

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 298 KB

english, 2000

25

X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding

Eigenbrot, Charles, Gerber, Nancy

Journal:

Natural Structural Biology

Année:

1997

Fichier:

PDF, 817 KB

1997

26

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

Kelley, Robert F., O'Connell, Mark P., Carter, Paul, Presta, Leonard, Eigenbrot, Charles, Covarrubias, Michael, Snedecor, Brad, Bourell, James H., Vetterlein, David

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.55 MB

english, 1992

27

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Kulagowski, Janusz J., Blair, Wade, Bull, Richard J., Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K., Hewitt, Peter R., Liima

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2012

28

Discovery and Optimization of C -2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Zak, Mark, Mendonca, Rohan, Balazs, Mercedesz, Barrett, Kathy, Bergeron, Philippe, Blair, Wade S., Chang, Christine, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S., Eigenbrot, Charles, Ghilardi,

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.95 MB

english, 2012

29

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

Jagath R. Junutula, Sunil Bhakta, Helga Raab, Karen E. Ervin, Charles Eigenbrot, Richard Vandlen, Richard H. Scheller, Henry B. Lowman

Journal:

Journal of Immunological Methods

Année:

2008

Langue:

english

Fichier:

PDF, 915 KB

english, 2008

30

Convergent Recognition of the IgE Binding Site on the High-Affinity IgE Receptor

Jennifer Stamos, Charles Eigenbrot, Gerald R Nakamura, Mark E Reynolds, JianPing Yin, Henry B Lowman, Wayne J Fairbrother, Melissa A Starovasnik

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 623 KB

english, 2004

31

A Trigger Squeezed

Charles Eigenbrot

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 279 KB

english, 2008

32

Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody

Rajkumar Ganesan, Charles Eigenbrot, Yan Wu, Wei-Ching Liang, Steven Shia, Michael T. Lipari, Daniel Kirchhofer

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2009

33

Structural and Functional Analysis of HtrA1 and Its Subdomains

Charles Eigenbrot, Mark Ultsch, Michael T. Lipari, Paul Moran, S. Jack Lin, Rajkumar Ganesan, Clifford Quan, Jeffrey Tom, Wendy Sandoval, Menno van Lookeren Campagne, Daniel Kirchhofer

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2012

34

New Insight into How Tissue Factor Allosterically Regulates Factor VIIa

Charles Eigenbrot, Daniel Kirchhofer

Journal:

Trends in Cardiovascular Medicine

Année:

2002

Langue:

english

Fichier:

PDF, 700 KB

english, 2002

35

IL-1H, AN INTERLEUKIN 1-RELATED PROTEIN THAT BINDS IL-18 RECEPTOR/IL-1Rrp

Guohua Pan, Phillip Risser, Weiguang Mao, Daryl T. Baldwin, Alan W. Zhong, Ellen Filvaroff, Dan Yansura, Lhney Lewis, Charles Eigenbrot, William J. Henzel, Richard Vandlen

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 484 KB

english, 2001

36

X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized anti-p185HER2 Antibody 4D5 and Comparison with Molecular Modeling

Charles Eigenbrot, Michael Randal, Leonard Presta, Paul Carter, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Année:

1993

Fichier:

PDF, 1.78 MB

1993

37

Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis

Yong Hannah Wen, Hartmut Koeppen, Roberto Garcia, Luis Chiriboga, Branden D. Tarlow, Brock A. Peters, Charles Eigenbrot, Herman Yee, German Steiner, M. Alba Greco

Journal:

Human Pathology

Année:

2007

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2007

38

High-affinity Human Antibodies from Phage-displayed Synthetic Fab Libraries with a Single Framework Scaffold

Chingwei V Lee, Wei-Ching Liang, Mark S Dennis, Charles Eigenbrot, Sachdev S Sidhu, Germaine Fuh

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 529 KB

english, 2004

39

Conformational Lability in Serine Protease Active Sites: Structures of Hepatocyte Growth Factor Activator (HGFA) Alone and with the Inhibitory Domain from HGFA Inhibitor-1B

Steven Shia, Jennifer Stamos, Daniel Kirchhofer, Bin Fan, Judy Wu, Raquel T. Corpuz, Lydia Santell, Robert A. Lazarus, Charles Eigenbrot

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 917 KB

english, 2005

40

Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine

Robert D. Fisher, Mark Ultsch, Andreas Lingel, Gabriele Schaefer, Lily Shao, Sara Birtalan, Sachdev S. Sidhu, Charles Eigenbrot

Journal:

Journal of Molecular Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2010

41

A Minimized M13 Coat Protein Defines the Requirements for Assembly into the Bacteriophage Particle

Tomer A Roth, Gregory A Weiss, Charles Eigenbrot, Sachdev S Sidhu

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 938 KB

english, 2002

42

Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation

Charles Eigenbrot, Y.Gloria Meng, Rajeswari Krishnamurthy, Michael T. Lipari, Leonard Presta, Brigitte Devaux, Terence Wong, Paul Moran, Sherron Bullens, Daniel Kirchhofer

Journal:

Journal of Molecular Biology

Année:

2003

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2003

43

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Christian Wiesmann, Germaine Fuh, Hans W. Christinger, Charles Eigenbrot, James A. Wells, Abraham M. de Vos

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 1.39 MB

english, 1997

44

An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

Antony W Burgess, Hyun-Soo Cho, Charles Eigenbrot, Kathryn M Ferguson, Thomas P.J Garrett, Daniel J Leahy, Mark A Lemmon, Mark X Sliwkowski, Colin W Ward, Shigeyuki Yokoyama

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 504 KB

english, 2003

45

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors

Hanan, Emily J., van Abbema, Anne, Barrett, Kathy, Blair, Wade S., Blaney, Jeff, Chang, Christine, Eigenbrot, Charles, Flynn, Sean, Gibbons, Paul, Hurley, Christopher A., Kenny, Jane R., Kulagowski, J

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2012

46

Disulfide locked variants of factor VIIa with a restricted β-strand conformation have enhanced enzymatic activity

Henry R. Maun, Charles Eigenbrot, Helga Raab, David Arnott, Lilian Phu, Sherron Bullens, Robert A. Lazarus

Journal:

Protein Science

Année:

2005

Langue:

english

Fichier:

PDF, 250 KB

english, 2005

47

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Liang, Jun, van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade, Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Ghilardi, Nico, G

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2013

48

Crystal and molecular structure of [Nd(tren)2(CH3CN)](ClO4)3

Eigenbrot, Charles W., Raymond, Kenneth N.

Journal:

Inorganic Chemistry

Année:

1982

Langue:

english

Fichier:

PDF, 520 KB

english, 1982

49

Crystal and molecular structure of the silver(II) and zinc(II) derivatives of meso-tetraphenylporphyrin. An exploration of crystal-packing effects on bond distance

Scheidt, W. Robert, Mondal, Jalal U., Eigenbrot, C. W., Adler, Alan, Radonovich, L. J., Hoard, J. L.

Journal:

Inorganic Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 609 KB

english, 1986

50

A Novel Exosite on Coagulation Factor VIIa and Its Molecular Interactions with a New Class of Peptide Inhibitors ‡

Roberge, Martin, Santell, Lydia, Dennis, Mark S., Eigenbrot, Charles, Dwyer, Mary A., Lazarus, Robert A.

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 629 KB

english, 2001