Volume 35; Issue 3

Drug Metabolism and Disposition

Volume 35; Issue 3

1

UDP-Glucuronosyltransferase 1A1 Is the Principal Enzyme Responsible for Etoposide Glucuronidation in Human Liver and Intestinal Microsomes: Structural Characterization of Phenolic and Alcoholic Glucuronides of Etoposide and Estimation of Enzyme Kinetics

Wen, Z., Tallman, M. N., Ali, S. Y., Smith, P. C.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 480 KB

english, 2006

2

Metabolism of Sirolimus in the Presence or Absence of Cyclosporine by Genotyped Human Liver Microsomes and Recombinant Cytochromes P450 3A4 and 3A5

Picard, N., Djebli, N., Sauvage, F.-L., Marquet, P.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 246 KB

english, 2006

3

Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by Nucleoside, Nucleotide, and Non-Nucleoside Reverse Transcriptase Inhibitors

Weiss, J., Theile, D., Ketabi-Kiyanvash, N., Lindenmaier, H., Haefeli, W. E.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 368 KB

english, 2006

4

Involvement of CYP2A6 in the Formation of a Novel Metabolite, 3-Hydroxypilocarpine, from Pilocarpine in Human Liver Microsomes

Endo, T., Ban, M., Hirata, K., Yamamoto, A., Hara, Y., Momose, Y.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 399 KB

english, 2006

5

CYP2A13 Metabolizes the Substrates of Human CYP1A2, Phenacetin, and Theophylline

Fukami, T., Nakajima, M., Sakai, H., Katoh, M., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 201 KB

english, 2006

6

Constitutive and 3-Methylcholanthrene-Induced Rat ALDH3A1 Expression Is Mediated by Multiple Xenobiotic Response Elements

Reisdorph, R., Lindahl, R.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 370 KB

english, 2006

7

Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines

Maeda, T., Hirayama, M., Kobayashi, D., Miyazawa, K., Tamai, I.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 455 KB

english, 2006

8

In Vitro and in Vivo Determination of Piperacillin Metabolism in Humans

Ghibellini, G., Bridges, A. S., Generaux, C. N., Brouwer, K. L. R.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 199 KB

english, 2006

9

Gender-Related Differences in Mycophenolate Mofetil-Induced Gastrointestinal Toxicity in Rats

Stern, S. T., Tallman, M. N., Miles, K. K., Ritter, J. K., Dupuis, R. E., Smith, P. C.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 246 KB

english, 2006

10

Effect of Genetic Variants of the Human Flavin-Containing Monooxygenase 3 on N- and S-Oxygenation Activities

Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J. R., Yamazaki, H.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 122 KB

english, 2006

11

Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor Activation

Senekeo-Effenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M.-F., Argikar, U., Kaeding, J., Trottier, J., Remmel, R. P., Ritter, J. K., Barbier, O., Tukey, R. H.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 420 KB

english, 2006

12

Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor- , Interleukin-1 , Interleukin-6, and Nuclear Factor- B in Two Models of Cholestasis

Lickteig, A. J., Slitt, A. L., Arkan, M. C., Karin, M., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 456 KB

english, 2006

13

Characterization of the Hepatic Disposition of Lanoteplase, a Rationally Designed Variant of Tissue Plasminogen Activator in Rodents

Komoriya, K., Kato, Y., Hayashi, Y., Ohsuye, K., Nishigaki, R., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 294 KB

english, 2006

14

Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100

Yu, R. Z., Kim, T.-W., Hong, A., Watanabe, T. A., Gaus, H. J., Geary, R. S.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 393 KB

english, 2006

15

Effect of Oral Ketoconazole on Intestinal First-Pass Effect of Midazolam and Fexofenadine in Cynomolgus Monkeys

Ogasawara, A., Kume, T., Kazama, E.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 183 KB

english, 2006

16

The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting

O'Donnell, C. J., Grime, K., Courtney, P., Slee, D., Riley, R. J.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 194 KB

english, 2006

17

Pharmacokinetics and Pharmacodynamics of Alfentanil in P-Glycoprotein-Competent and P-Glycoprotein-Deficient Mice: P-Glycoprotein Efflux Alters Alfentanil Brain Disposition and Antinociception

Kalvass, J. C., Olson, E. R., Pollack, G. M.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 213 KB

english, 2006

18

Inhibitory Effects of Benzoate on Chiral Inversion and Clearance of NG-Nitro-Arginine in Conscious Rats

Yan-Fei, X., Xiang-Jun, Z., Jie, L., Yong-Xiang, W.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 114 KB

english, 2006

19

Helices F-G Are Important for the Substrate Specificities of CYP3A7

Torimoto, N., Ishii, I., Toyama, K.-I., Hata, M., Tanaka, K., Shimomura, H., Nakamura, H., Ariyoshi, N., Ohmori, S., Kitada, M.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 744 KB

english, 2006

20

Functional Expression of Stereoselective Metabolism of Cephalexin by Exogenous Transfection of Oligopeptide Transporter PEPT1

Mitsuoka, K., Kato, Y., Kubo, Y., Tsuji, A.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 249 KB

english, 2006

21

Misuse of the Well-Stirred Model of Hepatic Drug Clearance

Yang, J., Jamei, M., Yeo, K. R., Rostami-Hodjegan, A., Tucker, G. T.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 97 KB

english, 2006

22

Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Human CYP51 Inhibitors

Ekins, S., Mankowski, D. C., Hoover, D. J., Lawton, M. P., Treadway, J. L., Harwood, H. J.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 372 KB

english, 2006

23

Glucuronidation of Anti-HIV Drug Candidate Bevirimat: Identification of Human UDP-glucuronosyltransferases and Species Differences

Wen, Z., Martin, D. E., Bullock, P., Lee, K.-H., Smith, P. C.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 497 KB

english, 2006

24

CAR2 Displays Unique Ligand Binding and RXR Heterodimerization Characteristics

Auerbach, S. S., DeKeyser, J. G., Stoner, M. A., Omiecinski, C. J.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 456 KB

english, 2006

25

Classification of Metabolites with Kernel-Partial Least Squares (K-PLS)

Embrechts, M. J., Ekins, S.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 105 KB

english, 2006

26

The Glucuronidation of 4-3-Keto C19- and C21-Hydroxysteroids by Human Liver Microsomal and Recombinant UDP-glucuronosyltransferases (UGTs): 6 - and 21-Hydroxyprogesterone Are Selective Substrates for UGT2B7

Bowalgaha, K., Elliot, D. J., Mackenzie, P. I., Knights, K. M., Miners, J. O.

Journal:

Drug Metabolism and Disposition

Année:

2006

Langue:

english

Fichier:

PDF, 251 KB

english, 2006