Volume 79; Issue 6

Chemical Biology & Drug Design

Volume 79; Issue 6

1

Synthesis and Preliminary Biologic Evaluation of 5-Substituted-2-(4-substituted phenyl)-1,3-Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors

Zhenyu Li, Peng Zhan, Lieve Naesens, Evelien Vanderlinden, Ailin Liu, Guanhua Du, Erik De Clercq, Xinyong Liu

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 185 KB

english, 2012

2

Revealing Interaction Mode between HIV-1 Protease and Mannitol Analog Inhibitor

Guan-Wen Yan, Yue Chen, Yixue Li, Hai-Feng Chen

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 708 KB

english, 2012

3

Computational and Biological Evaluation of Quinazolinone Prodrug for Targeting Pancreatic Cancer

Pavel Pospisil, Houari Korideck, Ketai Wang, Yongliang Yang, Lakshmanan K. Iyer, Amin I. Kassis

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 699 KB

english, 2012

4

3D-QSAR Studies on the Inhibitory Activity of Trimethoprim Analogues against Escherichia coli Dihydrofolate Reductase

Ramadoss Vijayaraj, Mekapothula Lakshmi Vasavi Devi, Venkatesan Subramanian, Pratim Kumar Chattaraj

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 209 KB

english, 2012

5

Synthesis, Biological Evaluation, and Structure–activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity

Carla M. S. Menezes, Gildardo Rivera, Marina A. Alves, Daniel N. do Amaral, Jean Pierre B. Thibaut, François Noël, Eliezer J. Barreiro, Lídia M. Lima

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 308 KB

english, 2012

6

Cationic Lipids Containing Cyclen and Ammonium Moieties as Gene Delivery Vectors

Qing-Dong Huang, Jiang Ren, Wen-Jing Ou, Yun Fu, Mao-Qiang Cai, Ji Zhang, Wen Zhu, Xiao-Qi Yu

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 430 KB

english, 2012

7

Prediction of HIV-1 Protease/Inhibitor Affinity using RosettaLigand

Gordon Lemmon, Kristian Kaufmann, Jens Meiler

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 894 KB

english, 2012

8

The Evolution of HLA-B*3501 Binding Affinity to Variable Immunodominant NP418-426 Peptides from 1918 to 2009 Pandemic Influenza A Virus: A Molecular Dynamics Simulation and Free Energy Calculation Study

Jingjing Guo, Xiaoting Wang, Huijun Sun, Huanxiang Liu, Yulin Shen, Xiaojun Yao

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 648 KB

english, 2012

9

Highly Potent Antidiuretic Antagonists: Conformational Studies of Vasopressin Analogues Modified with 1-Naphthylalanine Enantiomers at Position 2

Emilia A. Lubecka, Jerzy Ciarkowski, Adam Prahl, Emilia Sikorska

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 558 KB

english, 2012

10

Molecular Docking Studies of Novel Palmitoyl-ligands for Cyclooxygenase-2

Raghu Bhagavat, Asma Saqib, Chandrakant Karigar

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 588 KB

english, 2012

11

Microwave-assisted Synthesis and Bioevaluation of Some Semicarbazones

Laila Jafri, Farzana L. Ansari, Maryam Jamil, Saima Kalsoom, Sana Qureishi, Bushra Mirza

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 490 KB

english, 2012

12

Chemical Components in Extracts from Plastrum Testudinis with Proliferation-Promoting Effects on Rat Mesenchymal Stem Cells

Ting-Ting Wang, Wei Chen, He-Ping Zeng, Dong-Feng Chen

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 526 KB

english, 2012

13

Inhibition of Bacterial Virulence: Drug-Like Molecules Targeting the Salmonella enterica PhoP Response Regulator

Yat T. Tang, Rong Gao, James J. Havranek, Eduardo A. Groisman, Ann M. Stock, Garland R. Marshall

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 384 KB

english, 2012

14

Synthesis, Structure–Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole-3-Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors

Deyan Wu, Fangfang Jin, Weiqiang Lu, Jin Zhu, Cui Li, Wei Wang, Yun Tang, Hualiang Jiang, Jin Huang, Guixia Liu, Jian Li

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 856 KB

english, 2012

15

Multicomplex-Based Pharmacophore-Guided 3D-QSAR Studies of N-Substituted 2′-(Aminoaryl)Benzothiazoles as Aurora-A Inhibitors

Gu He, Minghua Qiu, Rui Li, Liang Ouyang, Fengbo Wu, Xiangrong Song, Li Cheng, Mingli Xiang, Luoting Yu

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2012

16

The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies

Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang, Ping Xu

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 423 KB

english, 2012

17

In Vitro Antioxidant Activity Study of Novel Chromone Derivatives

Narumol Phosrithong, Weerasak Samee, Patcharawee Nunthanavanit, Jiraporn Ungwitayatorn

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 258 KB

english, 2012

18

Free Energy Calculations on Snake Venom Metalloproteinase BaP1

Torsten Lingott, Irmgard Merfort, Thomas Steinbrecher

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 174 KB

english, 2012

19

Potential Selective Inhibitors against Rv0183 of Mycobacterium tuberculosis Targeting Host Lipid Metabolism

Parameswaran Saravanan, Vikash Kumar Dubey, Sanjukta Patra

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 507 KB

english, 2012

20

Preliminary Investigations of the Effect of Lipophilic Analogues of the Active Metabolite of Isoniazid Toward Bacterial and Plasmodial Strains

Tamara Delaine, Vania Bernardes-Génisson, Annaïk Quémard, Patricia Constant, Frédéric Cosledan, Bernard Meunier, Jean Bernadou

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 344 KB

english, 2012

21

Computational Insights into the Inhibition of Inosine 5′-Monophosphate Dehydrogenase by Mycophenolic Acid Analogs: Three-Dimensional Quantitative Structure–Activity Relationship and Molecular Docking Studies

Na Yang, Jian Wang, Zhi-Wei Wang, Qing-He Wang, Hong-Guang Yang, Xiu-Jun Wang, Mao-Sheng Cheng

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 397 KB

english, 2012

22

Insights into the Uptake Mechanism of NrTP, A Cell-Penetrating Peptide Preferentially Targeting the Nucleolus of Tumour Cells

Gandhi Rádis-Baptista, Beatriz G. de la Torre, David Andreu

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 486 KB

english, 2012

23

Issue Information

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2012