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Volume 2; Issue 8

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Bioorganic & Medicinal Chemistry Letters
Volume 2; Issue 8

Bioorganic & Medicinal Chemistry Letters

Volume 2; Issue 8

1

Graphical abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 342 KB

english, 1992

2

Cholinomimetics and Alzheimer's disease

Juan C. Jean, Walter H. Moos, Graham Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 345 KB

english, 1992

3

Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors

William S. Messer, Philip G. Dunbar, Taikyun Rho, Sumudra Periyasamy, Dan Ngur, Brenda R. Ellerbrock, Mark Bohnett, Kevin Ryan, Graham J. Durant, Wayne Hoss

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 406 KB

english, 1992

4

Design and synthesis of azabicyclic muscarinic agonists incorporating an oxime ether functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Michael S. Hadley, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 306 KB

english, 1992

5

A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Julie Hawkins, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 394 KB

english, 1992

6

Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

Alan P. Kozikowski, Abdul H. Fauq, Jacqueline H. Miller, Michael McKinney

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 400 KB

english, 1992

7

Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5

Kathryn B. Sanders, Anthony J. Thomas, Michael R. Pavia, Robert E. Davis, Linda L. Coughenour, Sharie L. Myers, Susan Fisher, Walter H. Moos

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 360 KB

english, 1992

8

Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP

Per Sauerberg, Preben H. Olesen, Peter D. Suzdak, Malcolm J. Sheardown, Charles H. Mitch, Barry D. Sawyer, Harlan E. Shannon

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 367 KB

english, 1992

9

Muscarinic agonist SAR of azaspirodioxolanes

G. Shapiro, P. Floersheim, R. Amstutz, H. Boddeke, G. Bolliger, S. Cottens, A. Enz, G. Gmelin, P. Gull, P. Supavilai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 472 KB

english, 1992

10

A rationale for the design and synthesis of m1 selective muscarinic agonists.

H. Tecle, T. Mirzadegan, W.H. Moos, D.W. Moreland, M.R. Pavia, R.D. Schwarz, R.E. Davis

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 355 KB

english, 1992

11

The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives

Eugene J. Trybulski, Richard H. Kramss, Richard M. Mangano, Herbert J. Brabander, Gerardo Francisco

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 368 KB

english, 1992

12

SR 46559 A and related aminopyridazines are potent muscarinic agonists with no cholinergic syndrome

Camille G. Wermuth, Jean-Jacques Bourguignon, Rémy Hoffmann, Robert Boigegrain, Roger Brodin, Jean-Paul Kan, Philippe Soubrié

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 424 KB

english, 1992

13

Rigid analogs of acetylcholine can be m1-selective agonists: implications for a rational treatment strategy in Alzheimer's disease

Abraham Fisher, David Gurwitz, Dov Barak, Rachel Haring, Ishai Karton, Rachel Brandeis, Zipora Pittel, Daniele Marciano, Haim Meshulam, Zvi Vogel, Eliahu Heldman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 479 KB

english, 1992

14

Muscarinic receptor probes based on amine congeners of pirenzepine and telenzepine

Kenneth A. Jacobson, Yishai Karton, Jesse Baumgold

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 403 KB

english, 1992

15

Acetylcholine-releasing agents as cognition enhancers. Structure-activity relationships of pyridinyl pendant groups on selected core structures.

Richard A. Earl, Melvyn J. Myers, Alexander L. Johnson, Richard M. Scribner, Mark A. Wuonola, George A. Boswell, Wendell W. Wilkerson, Victor J. Nickolson, S. William Tam, David R. Brittelli, Robert J

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 308 KB

english, 1992

16

Acetylcholine releasing agents as cognition activators. Chemistry and pharmacology of a series of ureas

Anthony J. Thomas, Jeffrey A. Kester, Donald E. Butler, Fred M. Hershenson, Robert E. Davis, John G. Marriott, Roy D. Schwarz, Carolyn J. Spencer, James P. Symons, Walter H. Moos

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 421 KB

english, 1992

17

The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties

Vlad E. Gregor, Mark R. Emmerling, Chitase Lee, Catherine J. Moore

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 306 KB

english, 1992

18

Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine

Gregory M. Shutske, Gina M. Bores, Katherine C. Bradshaw, Francis P. Huger, Kevin J. Kapples, Raymond D. Larsen, Douglas K. Rush, John D. Tomer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 502 KB

english, 1992

19

Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds

Hachiro Sugimoto, Youichi Iimura, Yoshiharu Yamanishi, Kiyomi Yamatsu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 347 KB

english, 1992