Volume 13; Issue 16

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Bioorganic & Medicinal Chemistry Letters
Volume 13; Issue 16

Bioorganic & Medicinal Chemistry Letters

Volume 13; Issue 16

1

Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate

Reen-Yen Kuo, Fang-Rong Chang, Chin-Chun Wu, Ramesh Patnam, Wei-Ya Wang, Ying-Chi Du, Yang-Chang Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 199 KB

english, 2003

2

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods

György M. Keserü

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 151 KB

english, 2003

3

Novel 3-O-acyl mesquitol analogues as free-Radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure–activity relationship

R. Jagadeeshwar Rao, Ashok K. Tiwari, U.Sampath Kumar, S.Venkat Reddy, Amtul Z. Ali, J.Madhusudana Rao

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 155 KB

english, 2003

4

5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents

Ranjit C. Desai, Wei Han, Edward J. Metzger, Jeffrey P. Bergman, Dominick F. Gratale, Karen L. MacNaul, Joel P. Berger, Thomas W. Doebber, Kwan Leung, David E. Moller, James V. Heck, Soumya P. Sahoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 184 KB

english, 2003

5

Design and synthesis of potent and selective macrocyclic thrombin inhibitors

Philippe G. Nantermet, James C. Barrow, Christina L. Newton, Janetta M. Pellicore, MaryBeth Young, S.Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Daniel R. McMasters, Youwei Yan, Lawrence C. Kuo, Jos

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 199 KB

english, 2003

6

Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II

Angela Casini, Silvio Caccia, Andrea Scozzafava, Claudiu T Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 139 KB

english, 2003

7

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide—two heads are better than one?

Angela Casini, Francesco Abbate, Andrea Scozzafava, Claudiu T Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 231 KB

english, 2003

8

The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds

Esther del Olmo, Marlon Garcı́a Armas, Mª Inés Ybarra, Josè Luis López, Patricia Oporto, Alberto Giménez, Eric Deharo, Arturo San Feliciano

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 160 KB

english, 2003

9

Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates

J.I. Levin, J.M. Chen, K. Cheung, D. Cole, C. Crago, E.Delos Santos, X. Du, G. Khafizova, G. MacEwan, C. Niu, E.J. Salaski, A. Zask, T. Cummons, A. Sung, J. Xu, Y. Zhang, W. Xu, S. Ayral-Kaloustian, G

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 208 KB

english, 2003

10

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities: a novel series of potential antidepressants

J.Ignacio Andrés, Jesús Alcázar, José M. Alonso, Rosa M. Alvarez, José M. Cid, Ana I. De Lucas, Javier Fernández, Sonia Martı́nez, Carmen Nieto, Joaquı́n Pastor, Margot H. Bakker, Ilse Biesmans, Lieve

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 249 KB

english, 2003

11

Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

Paola Barraja, Patrizia Diana, Antonino Lauria, Alessandra Montalbano, Anna Maria Almerico, Gaetano Dattolo, Girolamo Cirrincione, Giampietro Viola, Francesco Dall'Acqua

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 141 KB

english, 2003

12

Structure–activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-Ichiro Nishimura

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 172 KB

english, 2003

13

Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-Ichiro Nishimura

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 149 KB

english, 2003

14

Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1′ side chain

Stephen J. Davies, Andrew P. Ayscough, R.Paul Beckett, Ryan A. Bragg, John M. Clements, Sheila Doel, Christine Grew, Steven B. Launchbury, Gemma M. Perkins, Lisa M. Pratt, Helen K. Smith, Zoë M. Spavo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 176 KB

english, 2003

15

Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2′ and P3′ side chains

Stephen J. Davies, Andrew P. Ayscough, R.Paul Beckett, John M. Clements, Sheila Doel, Lisa M. Pratt, Zoë M. Spavold, S.Wayne Thomas, Mark Whittaker

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 154 KB

english, 2003

16

Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin

Patrick Hautefaye, Bernard Cimetière, Alain Pierré, Stéphane Léonce, John Hickman, William Laine, Christian Bailly, Gilbert Lavielle

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 227 KB

english, 2003

17

Topological virtual screening: A way to find new anticonvulsant drugs from chemical diversity

L. Bruno-Blanch, J. Gálvez, R. Garcı́a-Domenech

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 202 KB

english, 2003

18

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures

Federica Orvieto, Uwe Koch, Victor G. Matassa, Ester Muraglia

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 195 KB

english, 2003

19

Oxime bond formation for the covalent attachment of oligonucleotides on glass support

Eric Defrancq, Antoine Hoang, Françoise Vinet, Pascal Dumy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 204 KB

english, 2003

20

Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([18F]FEFE) for the in vivo visualisation and quantification of the β2-adrenergic receptor status in lung

Esther Schirrmacher, Ralf Schirrmacher, Oliver Thews, Wolfgang Dillenburg, Andreas Helisch, Ignatz Wessler, Roland Buhl, Sabine Höhnemann, Hans-Georg Buchholz, Peter Bartenstein, Hans-Jürgen Machulla,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 192 KB

english, 2003

21

2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

David R Mole, Imre Schlemminger, Luke A McNeill, Kirsty S Hewitson, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 197 KB

english, 2003

22

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics

Phaik-Eng Sum, David How, Nancy Torres, Peter J. Petersen, Joseph Ashcroft, Edmund I. Graziani, Frank E. Koehn, Tarek S. Mansour

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 189 KB

english, 2003

23

The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-Taxane derived mimics of taxol?

Joshua Howarth, Padraic Kenny, Susan McDonnell, Aine O'Connor

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 167 KB

english, 2003

24

Search compounds with antimicrobial activity by applying molecular topology to selected quinolones

S. Mut-Ronda, M.T. Salabert-Salvador, M.J. Duart, G.M. Antón-Fos

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 202 KB

english, 2003

25

Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid

G. Durand, A. Polidori, J.P. Salles, M. Prost, P. Durand, B. Pucci

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 162 KB

english, 2003

26

Suzuki cross-coupling approaches to the synthesis of bioactive 3-substituted and 5-substituted-4-methoxy-6-methyl-2-pyrones

Lester R. Marrison, Julia M. Dickinson, Ian J.S. Fairlamb

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 220 KB

english, 2003

27

A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori

Ni Cheng, Jian-Shu Xie, Min-Yue Zhang, Chang Shu, De-Xu Zhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 181 KB

english, 2003

28

Anti-atherogenic effects of 3,4-Dihydroxy hydrocinnamides

Sangku Lee, Chul-Ho Lee, Jung-Hoon Oh, Eun Eai Kim, Yang-Kyu Choi, Eun-Hee Kim, Woo Song Lee, Song-Hae Bok, Tae-Sook Jeong

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 122 KB

english, 2003

29

Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

Marian Flipo, Isabelle Florent, Philippe Grellier, Christian Sergheraert, Rebecca Deprez-Poulain

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 160 KB

english, 2003

30

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding

Toshihiro Aya, Andrew D. Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 281 KB

english, 2003

31

Sub-Nanomolar hMC1R Agonists by End-Capping of the Melanocortin Tetrapeptide His-d-Phe-Arg-Trp-NH2

L.N Koikov, F.H Ebetino, M.G Solinsky, D Cross-Doersen, J.J Knittel

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 149 KB

english, 2003

32

Oligonucleotides with strongly fluorescent groups π-Conjugated to a nucleobase: syntheses, melting temperatures, and conformation

Guan-Sheng Jiao, Kevin Burgess

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 332 KB

english, 2003

33

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Thomas E Renau, Roger Léger, Lubov Filonova, Eric M Flamme, Michael Wang, Rose Yen, Deidre Madsen, David Griffith, Suzanne Chamberland, Michael N Dudley, Ving J Lee, Olga Lomovskaya, William J Watkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 175 KB

english, 2003

34

Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin

Young-Jae You, Yong Kim, Nguyen-Hai Nam, Byung-Zun Ahn

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 159 KB

english, 2003

35

Facile preparation of DNA-tagged carbohydrates

Shinsuke Sando, Kazuki Matsui, Yusuke Niinomi, Nobuhiko Sato, Yasuhiro Aoyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 126 KB

english, 2003

36

4-Phenyl-4H-pyrans as IKCa channel blockers

Klaus Urbahns, Ervin Horváth, Johannes-Peter Stasch, Frank Mauler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 149 KB

english, 2003

37

Hit-to-Lead studies: The discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists

Andrew Baxter, Colin Bennion, Janice Bent, Kerry Boden, Steve Brough, Anne Cooper, Elizabeth Kinchin, Nicholas Kindon, Tom McInally, Mike Mortimore, Bryan Roberts, John Unitt

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 171 KB

english, 2003

38

Hypocholesterolemic activity of hesperetin derivatives

Tae-Sook Jeong, Eun Eai Kim, Chul-Ho Lee, Jung-Hoon Oh, Surk-Sik Moon, Woo Song Lee, Goo-Taeg Oh, Sangku Lee, Song-Hae Bok

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 121 KB

english, 2003

39

Anti-Androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor

Toshiyasu Ishioka, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 210 KB

english, 2003

40

Effect of the acyl groups on O→N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor

Yoshio Hamada, Hikaru Matsumoto, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 193 KB

english, 2003

41

Pyrimidinone antibiotics—heterocyclic analogues with improved antibacterial spectrum

Michael Brands, Yolanda Cancho Grande, Rainer Endermann, Reinhold Gahlmann, Jochen Krüger, Siegfried Raddatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 204 KB

english, 2003

42

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 58 KB

english, 2003

43

Contents List

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 112 KB

english, 2003

44

Contributors to this Issue

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Fichier:

PDF, 47 KB

2003

45

Graphical Abstracts

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 334 KB

english, 2003

46

Instructions to Contributors and GA example

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 121 KB

english, 2003