Volume 19; Issue 4

Bioorganic & Medicinal Chemistry

Volume 19; Issue 4

1

Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling

Frank J. Dekker, Christian Hedberg

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 559 KB

english, 2011

2

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Eduard Dolušić, Pierre Larrieu, Sébastien Blanc, Frédéric Sapunaric, Bernadette Norberg, Laurence Moineaux, Delphine Colette, Vincent Stroobant, Luc Pilotte, Didier Colau, Thierry Ferain, Graeme Frase

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2011

3

Lipophilic derivatives of leu-enkephalinamide: In vitro permeability, stability and in vivo nasal delivery

Cécile D. Cros, Istvan Toth, Joanne T. Blanchfield

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 423 KB

english, 2011

4

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

Sungwook Choi, Jeffery W. Kelly

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2011

5

Acridone alkaloids as potent inhibitors of cathepsin V

Richele P. Severino, Rafael V.C. Guido, Emerson F. Marques, Dieter Brömme, M. Fátima das G.F. da Silva, João B. Fernandes, Adriano D. Andricopulo, Paulo C. Vieira

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 446 KB

english, 2011

6

Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain

Kayo Takahashi, Gen Yamagishi, Toshiyuki Hiramatsu, Ayako Hosoya, Kayo Onoe, Hisashi Doi, Hiroko Nagata, Yasuhiro Wada, Hirotaka Onoe, Yasuyoshi Watanabe, Takamitsu Hosoya

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 491 KB

english, 2011

7

Corrigendum to “Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam” [Bioorg. Med. Chem. 17 (2009) 2219]

Li Pan, Young-Won Chin, Hee-Byung Chai, Tran Ngoc Ninh, Djaja Djendoel Soejarto, A. Douglas Kinghorn

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 170 KB

english, 2011

8

The potential antioxidant activity of 2,3-dihydroselenophene, a prototype drug of 4-aryl-2,3-dihydroselenophenes

Ricardo F. Schumacher, Alisson R. Rosário, Ana C.G. Souza, Carmine I. Acker, Cristina W. Nogueira, Gilson Zeni

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2011

9

Chisopanins A–K, 11 new protolimonoids from Chisocheton paniculatus and their anti-inflammatory activities

Ming-Hua Yang, Jun-Song Wang, Jian-Guang Luo, Xiao-Bing Wang, Ling-Yi Kong

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 999 KB

english, 2011

10

Amino-benzosuberone: A novel warhead for selective inhibition of human aminopeptidase-N/CD13

Sébastien Albrecht, Mira Al-Lakkis-Wehbe, Alban Orsini, Albert Defoin, Patrick Pale, Emmanuel Salomon, Céline Tarnus, Jean-Marc Weibel

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 868 KB

english, 2011

11

Structure–activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

Maria Chatzopoulou, Eduard Mamadou, Maria Juskova, Cathrine Koukoulitsa, Ioannis Nicolaou, Milan Stefek, Vassilis J. Demopoulos

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 666 KB

english, 2011

12

Brassinin oxidase mediated transformation of the phytoalexin brassinin: Structure of the elusive co-product, deuterium isotope effect and stereoselectivity

M. Soledade C. Pedras, Zoran Minic, Vijay K. Sarma-Mamillapalle

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 923 KB

english, 2011

13

Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site

Serdar Durdagi, Murat Şentürk, Deniz Ekinci, Halis Türker Balaydın, Süleyman Göksu, Ö. İrfan Küfrevioğlu, Alessio Innocenti, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2011

14

New imidazolidinedione derivatives as antimalarial agents

Liang Zhang, Ramadas Sathunuru, ThuLan Luong, Victor Melendez, Michael P. Kozar, Ai J. Lin

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 443 KB

english, 2011

15

LC–MS and NMR characterization of the purple chromophore formed in the o-aminobenzaldehyde assay of dihydrodipicolinate synthase

Voula Mitsakos, Sean R.A. Devenish, Paul A. O’Donnell, Juliet A. Gerrard, Craig A. Hutton

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 635 KB

english, 2011

16

Melampomagnolide B: A new antileukemic sesquiterpene

Shama Nasim, ShanShan Pei, Fred K. Hagen, Craig T. Jordan, Peter A Crooks

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 518 KB

english, 2011

17

Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads

Hung The Dang, Gyeoung Jin Kang, Eun Sook Yoo, Jongki Hong, Jae Sue Choi, Hyung Sik Kim, Hae Young Chung, Jee H. Jung

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 517 KB

english, 2011

18

Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase

Timothy D. Lash, Teresa R. Lamm, J. Andy Schaber, Wen-hsiang Chung, Eric K. Johnson, Marjorie A. Jones

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2011

19

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Jan Zitko, Martin Dolezal, Michaela Svobodova, Marcela Vejsova, Jiri Kunes, Radim Kucera, Petr Jilek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 211 KB

english, 2011

20

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Volodymyr M. Kysil, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya Okun

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 834 KB

english, 2011

21

Reaction of benzophenone triplet with aliphatic amines. What a potent neurotoxin can tell us about the reaction mechanism

Michelle L. Grimm, William J. Allen, Meghan Finn, Neal Castagnoli Jr., James M. Tanko

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 820 KB

english, 2011

22

Modelling topoisomerase I inhibition by minor groove binders

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2011

23

Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents

Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Li-Jun Wang, Chang-An Geng, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 952 KB

english, 2011

24

Editorial board

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 44 KB

english, 2011

25

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2011

26

Bioorganic & Medicinal Chemistry Reviews and Perspectives

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 129 KB

english, 2011