Volume 17; Issue 1

Bioorganic & Medicinal Chemistry

Volume 17; Issue 1

1

Corrigendum to “Alachalasins A–G, new cytochalasins from the fungus Stachybotrys charatum” [Bioorg. Med. Chem. 16 (2008) 2627–2634]

Yonggang Zhang, Renrong Tian, Shuchun Liu, Xulin Chen, Xingzhong Liu, Yongsheng Che

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 107 KB

english, 2009

2

Corrigendum to “Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine” [Bioorg. Med. Chem. 16 (2008) 2148–2155]

Chengwei Li, Mark N. Prichard, Brent E. Korba, John C. Drach, Jiri Zemlicka

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 116 KB

english, 2009

3

Inhibition of Aquaporin 4 by antiepileptic drugs

Vincent J. Huber, Mika Tsujita, Ingrid L. Kwee, Tsutomu Nakada

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 296 KB

english, 2009

4

Identification of Aquaporin 4 inhibitors using in vitro and in silico methods

Vincent J. Huber, Mika Tsujita, Tsutomu Nakada

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 326 KB

english, 2009

5

Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: Molecular docking analysis and pharmacological studies

Vittoria Colotta, Francesca Capelli, Ombretta Lenzi, Daniela Catarzi, Flavia Varano, Daniela Poli, Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea, Diego Dal Ben, Rosaria Volpini, Gloria Cristalli,

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2009

6

Design, Synthesis and Pharmacological Screening of Novel Antihypertensive Agents Using Hybrid Approach

Shashikant V. Bhandari, Kailash G. Bothara, Ajit A. Patil, Trupti S. Chitre, Aniket P. Sarkate, Suraj T. Gore, Sudarshan C. Dangre, Chetan V. Khachane

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 250 KB

english, 2009

7

Spiro(imidazo[1,2-a]pyrano[2,3-c]pyridine-9-indenes) as inhibitors of gastric acid secretion

Andreas Marc Palmer, Sandra Chrismann, Gabriela Münch, Christof Brehm, Peter Jan Zimmermann, Wilm Buhr, Jörg Senn-Bilfinger, Martin Philipp Feth, Wolfgang Alexander Simon

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 362 KB

english, 2009

8

Synthesis and evaluation of electron-rich curcumin analogues

Michael W. Amolins, Laura B. Peterson, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 609 KB

english, 2009

9

Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure

Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Hiroyuki Kagechika, Yasuyuki Endo

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 520 KB

english, 2009

10

Effect of methyl substitution in a ligand on the selectivity and binding affinity for a nucleobase: A case study with isoxanthopterin and its derivatives

Burki Rajendar, Arivazhagan Rajendran, Yusuke Sato, Seiichi Nishizawa, Norio Teramae

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 473 KB

english, 2009

11

Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression

John R. Cashman, Troy Voelker, Robert Johnson, Aaron Janowsky

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 300 KB

english, 2009

12

Synthesis and biological activity of 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives, novel pro-apoptotic mitochondrial targeted agents

L. Dalla Via, A.M. Marini, S. Salerno, C. La Motta, M. Condello, G. Arancia, E. Agostinelli, A. Toninello

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2009

13

QSAR studies on BK channel activators

Alessio Coi, Francesca Lidia Fiamingo, Oreste Livi, Vincenzo Calderone, Alma Martelli, Ilaria Massarelli, Anna Maria Bianucci

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 217 KB

english, 2009

14

6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties

Pınar Kasaplar, Özgür Yılmazer, Ali Çağır

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 258 KB

english, 2009

15

Structure–activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors

Akihito Hirabayashi, Harunobu Mukaiyama, Hiroaki Kobayashi, Hiroaki Shiohara, Satoko Nakayama, Motoyasu Ozawa, Keiji Miyazawa, Keiko Misawa, Hideki Ohnota, Masayuki Isaji

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 677 KB

english, 2009

16

Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue

Herbert Schott, Klaus Hamprecht, Sarah Schott, Timm C. Schott, Reto A. Schwendener

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 321 KB

english, 2009

17

Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series

Maria A.F. Vera-DiVaio, Antônio C.C. Freitas, Helena C. Castro, Sérgio de Albuquerque, Lucio M. Cabral, Carlos R. Rodrigues, Magaly G. Albuquerque, Rita C.A. Martins, Maria G.M.O. Henriques, Luiza R.S

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 565 KB

english, 2009

18

Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides

Esther Vicente, Silvia Pérez-Silanes, Lidia M. Lima, Saioa Ancizu, Asunción Burguete, Beatriz Solano, Raquel Villar, Ignacio Aldana, Antonio Monge

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 369 KB

english, 2009

19

A simple synthesis of four stereoisomers of roseoside and their inhibitory activity on leukotriene release from mice bone marrow-derived cultured mast cells

Arata Yajima, Yutaka Oono, Ryusuke Nakagawa, Tomoo Nukada, Goro Yabuta

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 341 KB

english, 2009

20

High transfection efficiency and low toxicity cationic lipids with aminoglycerol–diamine conjugate

Boon-ek Yingyongnarongkul, Widchaya Radchatawedchakoon, Aungkana Krajarng, Ramida Watanapokasin, Apichart Suksamrarn

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2009

21

Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device

Kazusa Nishiyama, Yoichi Takakusagi, Tomoe Kusayanagi, Yuki Matsumoto, Shiori Habu, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Hideyo Takahashi, Hideaki Natsugari, Susumu Kobayashi

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 419 KB

english, 2009

22

Search for new pharmacophores for antimalarial activity. Part II: Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines

S. Madapa, Z. Tusi, A. Mishra, K. Srivastava, S.K. Pandey, R. Tripathi, S.K. Puri, S. Batra

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 289 KB

english, 2009

23

QSAR and complex network study of the chiral HMGR inhibitor structural diversity

Isela García, Cristian Robert Munteanu, Yagamare Fall, Generosa Gómez, Eugenio Uriarte, Humberto González-Díaz

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2009

24

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure–activity relationship analysis

Toshiyuki Harada, Yoshiaki Nakagawa, Randy M. Wadkins, Philip M. Potter, Craig E. Wheelock

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2009

25

Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas

Kekeli Ekoue-Kovi, Kimberly Yearick, Daniel P. Iwaniuk, Jayakumar K. Natarajan, John Alumasa, Angel C. de Dios, Paul D. Roepe, Christian Wolf

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 309 KB

english, 2009

26

Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity

Domenica Torino, Adriano Mollica, Francesco Pinnen, Federica Feliciani, Susanna Spisani, Gino Lucente

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 260 KB

english, 2009

27

Facilitated phospholipid translocation in vesicles and nucleated cells using synthetic small molecule scramblases

Kristy M. DiVittorio, Frank T. Hofmann, James R. Johnson, Lica Abu-Esba, Bradley D. Smith

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 450 KB

english, 2009

28

Discovery and structure–activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists

Masahiko Okano, Jun Mito, Yasufumi Maruyama, Hirofumi Masuda, Tomoko Niwa, Shin-ichiro Nakagawa, Yoshitaka Nakamura, Akira Matsuura

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 378 KB

english, 2009

29

Molecular design of protein-based nanocapsules for stimulus-responsive characteristics

Kentaro Sao, Masaharu Murata, Kaori Umezaki, Yuri Fujisaki, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Makoto Hashizume

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2009

30

Enaminones 8: CoMFA and CoMSIA studies on some anticonvulsant enaminones

Patrice L. Jackson, K.R. Scott, William M. Southerland, Ya-Yin Fang

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 476 KB

english, 2009

31

Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based ω-acidic amino acids as glutamate receptors ligands

Rosanna Filosa, M. Carmela Fulco, Maura Marinozzi, Nicola Giacchè, Antonio Macchiarulo, Antonella Peduto, Antonio Massa, Paolo de Caprariis, Christian Thomsen, Claus T. Christoffersen, Roberto Pellicc

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 365 KB

english, 2009

32

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

Nan Zhang, Semiramis Ayral-Kaloustian, Thai Nguyen, Richard Hernandez, Judy Lucas, Carolyn Discafani, Carl Beyer

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 259 KB

english, 2009

33

Alantrypinone and its derivatives: Synthesis and antagonist activity toward insect GABA receptors

Takayuki Watanabe, Mitsuhiro Arisawa, Kenji Narusuye, Mohommad Sayed Alam, Kazumi Yamamoto, Masaaki Mitomi, Yoshihisa Ozoe, Atsushi Nishida

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 622 KB

english, 2009

34

Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes

Renata B. Lacerda, Cleverton K.F. de Lima, Leandro L. da Silva, Nelilma C. Romeiro, Ana Luisa P. Miranda, Eliezer J. Barreiro, Carlos A.M. Fraga

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 917 KB

english, 2009

35

Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH

Leonie wyffels, Sylvie De Bruyne, Peter Blanckaert, Didier M. Lambert, Filip De Vos

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 406 KB

english, 2009

36

Potent and orally bioavailable CCR4 antagonists: Synthesis and structure–activity relationship study of 2-aminoquinazolines

Kazuhiro Yokoyama, Noriko Ishikawa, Susumu Igarashi, Noriyuki Kawano, Naoyuki Masuda, Wataru Hamaguchi, Shingo Yamasaki, Yohei Koganemaru, Kazuyuki Hattori, Takahiro Miyazaki, Shin-ichi Ogino, Yuzo Ma

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 257 KB

english, 2009

37

Search for new pharmacophores for antimalarial activity. Part I: Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides

S. Madapa, Z. Tusi, D. Sridhar, A. Kumar, M.I. Siddiqi, K. Srivastava, A. Rizvi, R. Tripathi, S.K. Puri, G.B. Shiva Keshava, P.K. Shukla, S. Batra

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 589 KB

english, 2009

38

Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki

Yoon Su Baek, Young Bae Ryu, Marcus J. Curtis-Long, Tae Joung Ha, Rajesh Rengasamy, Min Suk Yang, Ki Hun Park

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 238 KB

english, 2009

39

Arthrobacter sp. lipase immobilization for preparation of enantiopure masked β-amino alcohols

Asha Chaubey, Rajinder Parshad, Pankaj Gupta, Subhash C. Taneja, Ghulam N. Qazi, C.R. Rajan, S. Ponrathnam

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 212 KB

english, 2009

40

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

Rosanna Filosa, Antonella Peduto, Simone Di Micco, Paolo de Caprariis, Michela Festa, Antonello Petrella, Giovanni Capranico, Giuseppe Bifulco

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2009

41

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines

Daniel Canals, David Mormeneo, Gemma Fabriàs, Amadeu Llebaria, Josefina Casas, Antonio Delgado

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 305 KB

english, 2009

42

4-Fluoro-N-butylphenylacetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells

Chung-Hsien Liu, Li-Jiau Huang, Sheng-Chu Kuo, Tsung-Hsien Lee, Kan-Jen Tsai, Hsu-Chin Chan

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 647 KB

english, 2009

43

Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Takahiro Nishimaru, Masako Sano, Yoshihiro Yamaguchi, Tateaki Wakamiya

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 216 KB

english, 2009

44

Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer

Toshifumi Hirata, Misato Fujii, Kazuhiro Akita, Noriyuki Yanaka, Kaori Ogawa, Masanori Kuroyanagi, Daiki Hongo

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 255 KB

english, 2009

45

Antibacterial 5′-O-(N-dipeptidyl)-sulfamoyladenosines

P. Van de Vijver, G.H.M. Vondenhoff, S. Denivelle, J. Rozenski, J. Verhaegen, A. Van Aerschot, P. Herdewijn

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 295 KB

english, 2009

46

Support for small molecule inhibition of aquaporin 4

Vincent J. Huber

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 117 KB

english, 2009

47

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 762 KB

english, 2009

48

Editorial board

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 50 KB

english, 2009

49

Instructions to contributors

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 44 KB

english, 2009