Volume 278; Issue 3

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Toxicology
Volume 278; Issue 3

Toxicology

Volume 278; Issue 3

1

Genotoxic thresholds, DNA repair, and susceptibility in human populations

Gareth J.S. Jenkins, Zoulikha Zaïr, George E. Johnson, Shareen H. Doak

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 249 KB

english, 2010

2

Gene–environmental interactions and organophosphate toxicity

Andrew C. Povey

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 510 KB

english, 2010

3

Human primary bronchial lung cell constructs: The new respiratory models

Kelly BéruBé, Zoë Prytherch, Claire Job, Tracy Hughes

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 677 KB

english, 2010

4

AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes

Karen Wallace, Emma A. Fairhall, Keith A. Charlton, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1009 KB

english, 2010

5

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

Frédéric Y. Bois, Masoud Jamei, Harvey J. Clewell

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 541 KB

english, 2010

6

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

Sebastian Greenhough, Claire N. Medine, David C. Hay

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 395 KB

english, 2010

7

Post-translational modification by SUMO

Zara Hannoun, Sebastian Greenhough, Ellis Jaffray, Ronald T. Hay, David C. Hay

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 342 KB

english, 2010

8

British Toxicology Society Special Reviews 2010

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 56 KB

english, 2010

9

A metabonomic approach for mechanistic exploration of pre-clinical toxicology

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 865 KB

english, 2010

10

Food allergy – science and policy needs – The UK Food Standards Agency Research Programme

Joelle Buck, Sue Hattersley, Ian Kimber

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 210 KB

english, 2010

11

Reduction in dog numbers in regulatory one-month toxicology studies without compromising scientific quality: Challenging the status quo

Kristian Konigsson, Sally Robinson, Hans Harlemann

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 239 KB

english, 2010

12

Genes from liver tissue affected in phthalate treated rats, coupled with structural analysis of phthalates jointly predict testicular toxicity and elucidates possible mechanisms

Dordana Apic, Frank Bonner, Bojana Cosovic, Robert B. Russell

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2010

13

Valvular heart lesions in Han Wistar rats dosed with ALK5 inhibitors

Mark J. Anderton, Annabelle Heier, Alex Bell, Claire Sadler, Martin Pass, Steve Powell, Howard R. Mellor, Ruth A. Roberts

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 66 KB

english, 2010

14

Tesaglitazar and PPAR gamma agonism in the human kidney

Tamara J. Nicolson, Ruth R.A. Roberts

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 66 KB

english, 2010

15

Protective effects of clothing on the in vitro absorption of chemical warfare agents

Hazem Matar, Shirley C. Price, Robert P. Chilcott

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 68 KB

english, 2010

16

Temporal effects of disrobing on the skin absorption of chemical warfare agents and CW agent simulants

Hazem Matar, Shirley C. Price, Robert P. Chilcott

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 112 KB

english, 2010

17

Myofibroblast depletion during acute CCl4 injury delays hepatocyte injury and promotes liver regeneration

Angela Douglass, Helen Marshall, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 96 KB

english, 2010

18

Biological and toxicological consequences of fasting mice on paracetamol-induced hepatic apoptosis and anti-inflammatory HMGB1 modification

Daniel J. Antoine, Dominic P. Williams, Anja Kipar, B. Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 63 KB

english, 2010

19

The trans-differentiation of pancreatic acinar cells into hepatocytes is mediated by a suppression of WNT signalling

Karen Wallace, Stefan Hoppler, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 919 KB

english, 2010

20

Hepatic myofibroblasts are pro-inflammatory and activate NF-κB in monocytes via a soluble factor

Stephen Hill, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 68 KB

english, 2010

21

Acute oestradiol (E2) administration to mice results in liver portal tract inflammation

Andrew Axon, David E. Cowie, Fiona Oakley, Faith M. Williams, Peter G. Blain, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 64 KB

english, 2010

22

Development and validation of a pre-clinically relevant phototoxicity screen

Graham J. Gandy, James A. Dykens, Gareth P. Phillips

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 182 KB

english, 2010

23

The role of selective PPARδ agonists in hepatic steatosis

Wojciech Garbacz, Larry Higgins, Colin Palmer

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 168 KB

english, 2010

24

Modified static diffusion cells for decontamination modelling

Joanne Larner, David R. Jones, Shirley C. Price, Robert P. Chilcott

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 548 KB

english, 2010

25

Investigation into the effect of the adenylate cyclise inhibitor, 2′5′-dideoxyadenosine, on steroidogenesis in isolated primary rat adrenal cells

Julie A. Eakins, Eisha Comar, Russell Huby

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2010

26

Development of an in vitro model to study steroidogenesis in isolated primary rat adrenal cells

Julie A. Eakins, Russell Huby, Dearg Brown

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2010

27

The non-genotoxic hepatocarcinogen Phenobarbital causes persistent changes in the expression of liver microRNAs in the male Fischer rat

Costas Koufaris, Jayne Wright, Richard Currie, Nigel J. Gooderham

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 531 KB

english, 2010

28

In vitro investigation of the role of cyp dependent metabolism in drug hepatotoxicity using the THLE-CYP cell panel

Alison J. Foster, Mhairi L. Greer, Rebecca Coates, Tim J.D. Smith, J. Gerry Kenna

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 370 KB

english, 2010

29

Oxidative stress via hydrogen peroxide and Menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes

Emma M. Large, Catherine J. Henderson, David J. Flint, M. Helen Grant

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 179 KB

english, 2010

30

The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials

Amy E. Mercer, Ian M. Copple, James L. Maggs, B. Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 280 KB

english, 2010

31

The kinetics of 2,4-dinitrochlorobenzene (DNCB)- and trimellitic anhydride (TMA)-induced interleukin (IL)-17A and IL-17F production in murine skin

Mark D. Hayes, Craig Portsmouth, Ian Kimber, Rebecca J. Dearman

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 61 KB

english, 2010

32

Multidisciplinary approaches to toxicology in nanotechnologies and nanosciences

Bryony L. Ross, Julia Varet, Steven M. Hankin

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 72 KB

english, 2010

33

An investigation of the toxicity of silver nanoparticles to HL60 and Jurkat cells in vitro

Passapan Sriwichai, Faith M. Williams, Christina Lye, Angela Silmon, Elaine Mutch

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 304 KB

english, 2010

34

Susceptibility of alternative mRNA processing to interference by small molecules; implications for drug design and toxicity

Emanuela Zaharieva, Kevin Chipman, Matthias Soller

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 117 KB

english, 2010

35

Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy

Helen L. Marshall, Fiona Oakley, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 311 KB

english, 2010

36

Investigation into the metabolism and toxicity of nefazodone and buspirone

Nicola Lane, James Maggs, Kevin Park, Dominic Williams

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 289 KB

english, 2010

37

Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue

Hayley Webb, Jonathan Duckworth, Paul Turnpenny, Iain Gardner, Dennis Smith, Kevin Park, Dominic Williams

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 97 KB

english, 2010

38

Effect of chromium and cobalt ions on phase I and phase Ii enzymatic activities in freshly isolated rat hepatocytes

Grace A. Afolaranmi, Catherine Henderson, M. Helen Grant

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 62 KB

english, 2010

39

Definition of chemical and molecular mechanisms of artemisinin embryotoxicity

Ian Copple, Han Aw Yeang, Junnat Hamdam, James Maggs, Jean Sathish, Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 70 KB

english, 2010

40

The minipig as a model for intranasal dosing

Peter Glerup, Stig Mølgaard, Lars Andersen, Andy Makin

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 58 KB

english, 2010

41

Development of a porcine model for examining the effect of debriding agents

Peter Glerup, Mikala Skydsgaard, Jes Tovborg Jensen, Signe Klastrup

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 138 KB

english, 2010

42

Extracorporeal membranous oxygenation in a porcine non-heart beating liver model of organ preservation – A tool for improved hepatocyte isolation

Mohamed Saleem Noormohamed, David E. Cowie, Steven A. White, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 141 KB

english, 2010

43

Stem Cells for Safer Medicines (SC4SM): A public–private consortium to enhance medicines safety assessment

Paul A. Duffy, Frank Bonner

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 62 KB

english, 2010

44

Comparison of plasma concentrations in rats exposed to aerosols of a long acting β-agonist (LABA) in flow-through and flow-past inhalation chambers

Paul A. Smith, Paul M. Newham, Paul Lambert, Alan Dunlop, Stephen L. Keech

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 62 KB

english, 2010

45

In-house validation of the modified Irwin's test parameters following oral administration of chlorpromazine hydrochloride in Wistar rats

Darpesh Gohel, Uday Kapurkar, Poonam Mehta, Virendra Kumar Tiwari

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 59 KB

english, 2010

46

Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

David J. McGarry, C. Roland Wolf, Colin J. Henderson

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2010

47

REACH: The need for a truly multidisciplinary approach towards the integration of toxicological, epidemiological and environmental sciences with socio-economic analysis

Philip Holmes, Meg Postle, Nigel Tuffnell, Daniel Vencovsky, Panos Zarogiannis

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

48

Cytotoxic effect of dibutylphthalate and/or methomyl on cerebellum and cerebrum of male albino rats

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

49

Anthracene polyamine conjugates induce cell death in human leukaemic cells

Radiah A. Ghani, Navneet Kaur, Otto Phanstiel, Heather M. Wallace

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 63 KB

english, 2010

50

Use of minipigs in non-clinical juvenile toxicology studies

Andrew Makin, Christina Skytte, Nanna Grand

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 74 KB

english, 2010

51

In silico discovery of on- and off-target effects of beta-blockers

Anton Yuryev, Martin J. Griffies

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 61 KB

english, 2010

52

Assessment of hearing dysfunction induced by industrial chemicals in presence or absence of noise: A weight of evidence approach

Adolf Vyskocil, François Lemay, Tony Leroux, France Gagnon, Martine Gendron, Amar Boudjerida, Ginette Truchon, Sophie Lim, Claude Viau

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 61 KB

english, 2010

53

3D human cell culture: A novel system for testing drug toxicity

Jun Li, Niall Blease, Fiona Saunders, Heather M. Wallace

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 73 KB

english, 2010

54

Subacute toxicity of mixtures containing perfluorocarboxylic acids and related “peroxisome proliferators”

Michaela Benton, Richard H. Hinton, Shirley C. Price, Julie A. Howarth

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 74 KB

english, 2010

55

Possible developmental toxicity associated with landfill sites in the UK

Annette E. Ewence, Elizabeth J. Lawton, Paul C. Rumsby

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 65 KB

english, 2010

56

Increase of transepithelial resistance (TER) after removal of Cisplatin from LLC-PK1 monolayers

Nurul H. Othman, Heather M. Wilson, Gabrielle M. Hawksworth

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 78 KB

english, 2010

57

Dietary nickel intake in the canary islands (Spain): A total diet study

Dailos González Weller, Ángel J. Gutiérrez, Arturo Hardisson de la Torre, Carmen Rubio Armendáriz

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 62 KB

english, 2010

58

Cyclophosphamide causes transgenerational genomic instability in mice

Colin D. Glen, Lydia Djenoune, Yuri E. Dubrova

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 74 KB

english, 2010

59

Inside-out vesicles expressing multi-drug resistance protein (MRP) 2 and MRP4: Evaluation using fluorescent and radiolabelled substrates

Zoe Riches, Helen Pearce, Gabrielle M. Hawksworth

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 63 KB

english, 2010

60

Bacterial metabolic ‘toxins’: A new mechanism for lactose and food intolerance, and irritable bowel syndrome

A.K. Campbell, S.B. Matthews, N. Vassel, C.D. Cox, R. Naseem, J. Chaichi, I.B. Holland, J. Green, K.T. Wann

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 658 KB

english, 2010

61

Editorial Board

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 40 KB

english, 2010

62

Nrf2 mediates induction of cytoprotective genes in response to Cd exposure

Akeem O. Lawal, Elizabeth M. Ellis

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2010

63

Modified mouse model of tumourigenisis: Utility in the evaluation of the safety of therapeutics for cutaneous scar reduction

Richard Jones, Fiona Houghton, Dawn Cunningham, Alexandra Pilbrow, Hugh Laverty, Nick. L. Occleston

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 83 KB

english, 2010

64

Chronic elevated systemic glucocorticoid results in widespread pancreatic–hepatic trans-differentiation in vivo

Karen Wallace, Steven A. White, James A. Shaw, Paul A. Flecknell, Alastair D. Burt, Matthew C. Wright

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 907 KB

english, 2010

65

Optimising cell models for detecting drug-induced mitochondrial dysfunction

Katharine Howe, Laura Bazley, Shuang Song, James Dykens

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 80 KB

english, 2010

66

Mechanism of action of liver growth induced by peroxisome proliferators

Abeer H. Amer, Abdullah al-Kholaifi, Timothy W. Gant, David R. Bell

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 236 KB

english, 2010

67

The effect of SUMO modification on hepatic differentiation from hESCs

Zara Hannoun, Ellis Jaffray, Sebastian Greenhough, Ian Wilmut, John P. Iredale, Ronald T. Hay, David C. Hay

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 482 KB

english, 2010

68

Mechanistic studies on the tissue specific carcinogenicity of the cooked meat-derived carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine

Corrinne V. Segal, Qianxin Wu, Chris J. Powell, Nigel J. Gooderham

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 780 KB

english, 2010

69

Evaluation of the relationship between inhibition of the bile salt export pump in vitro and risk of drug-induced liver injury in man

Sarah Dawson, Simone Stahl, Jane Barber, Claire Summers, Nikki Paul, J. Gerald Kenna.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 124 KB

english, 2010

70

Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites

Thomas G. Hammond, Sophie L. Regan, Xiaoli Meng, James L. Maggs, Rosalind E. Jenkins, Gerry L. Kenna, Jean G. Sathish, Dominic P. Williams, B. Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 325 KB

english, 2010

71

The metabolism of carbamazepine in fresh rodent hepatocyte suspensions: The effect of bromine substitution on metabolism

Sophie Regan, Emma Elliot, James Maggs, Andrew Stachulski, Dominic Williams, Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 269 KB

english, 2010

72

The effect of extracellular matrix (ECM) on 2,4-dinitrochlorobenzene (DNCB)-induced responses of the dendritic cell surrogate THP-1 cells

Craig F. Portsmouth, Geoff Blunt, Gavin Maxwell, Ruth Pendlington, Ian Kimber, Rebecca J. Dearman

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 73 KB

english, 2010

73

The effects of time of treatment on statin muscle toxicity: Preliminary characterization of a human muscle cell line

Rowena H. Gee, Nick J. Plant, Jonathan D. Johnston, Kate E. Plant

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 73 KB

english, 2010

74

Chemical allergen induced IgE production and type 2 cytokines expression: Elevated responses in ageing mice

Rebecca J. Dearman, Ian Kimber

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 62 KB

english, 2010

75

Characterisation of bleomycin-induced cytotoxicity in mammalian alveolar type II cells

Michael S. Anders, Amy E. Mercer, B. Kevin Park

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 60 KB

english, 2010

76

Optimisation of mass casualty decontamination procedures in vitro

David R. Jones, Joanne Larner, Shirley C. Price, Robert P. Chilcott

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 373 KB

english, 2010