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Volume 262; Issue 1

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Toxicology
Volume 262; Issue 1

Toxicology

Volume 262; Issue 1

1

Developing an in vitro methods for assessing the carcinogenic potential of compounds to the kidney

Katarzyna Bloch, Andrew Evans, Edward A. Lock

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 60 KB

english, 2009

2

The in vitro efficacy of haemostatic products in the presence of chemical warfare agents—Sulphur mustard (HD) and VX

Charlotte A. Hall, Helen L. Lydon, Christopher H. Dalton, J. Kevin Chipman, Robert P. Chilcott, John S. Graham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 183 KB

english, 2009

3

Improved risk assessment of chemicals through the application of toxicokinetic information: Opportunities for the replacement, reduction and refinement of animal use

Stuart Creton, Richard Billington, Will Davies, Matthew P. Dent, Gabrielle M. Hawksworth, Simon Parry, Kim Z. Travis

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 270 KB

english, 2009

4

Analysis of the effects of cruciferous vegetable consumption on human metabolic phenotype analysed by UPLC-mass spectrometry

William M. Edmands, Florian Geier, Paul Benton, Elaine Holmes, Nigel J. Gooderham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 147 KB

english, 2009

5

Involvement of drug-specific CD4+ and CD8+ T-cells in trimethoprim-mediated hepatitis

Sabah El-Ghaiesh, Sidonie Lavergne, John Farell, Wing Syn, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 55 KB

english, 2009

6

The polyamine transport system: A means of selective delivery of potentially toxic agents to cancer cells?

Radiah A. Ghani, Andrew J. Palmer, Navneet Kaur, Otto Phanstiel, Heather M. Wallace

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 131 KB

english, 2009

7

Comparison between zebrafish and Hep G2 assays for the predictive identification of hepatotoxins

Mathew Jones, Jonathan S. Ball, Andrew Dodd, Adrian J. Hill

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 237 KB

english, 2009

8

Assessment of an ibuprofen metabolism by zebrafish larvae, using liquid chromatography–mass spectrometry (LC–MS)

Huw S. Jones, Henry T. Trollope, Thomas H. Hutchinson, Grace H. Panter, J. Kevin Chipman

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 392 KB

english, 2009

9

Generation of cell lines to investigate redox modulated dimer formation of Cys326-hOGG1

Rachael M. Kershaw, Daniel J. Smart, Nikolas J. Hodges

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 286 KB

english, 2009

10

In vitro toxicology of 2-propenyl and 3-butenyl glucosinolate derivatives

Nurul Huda Abd Kadir, John T. Rossiter, Nigel J. Gooderham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 361 KB

english, 2009

11

Whole-body imaging of UV-fluorescent chemical warfare simulants: A potentially quantitative technique for the optimisation of mass casualty decontamination procedures

Joanne Larner, Hazem Matar, David R. Jones, Richard Amlôt, Holly Carter, Elizabeth A. Turner, Shirley C. Price, Robert P. Chilcott

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 58 KB

english, 2009

12

Use of HPLC/UPLC instead of photometry for evaluation of MTT in in vitro irritation assays based on human reconstructed tissue for assessment of coloured test materials

Claudine Faller, Thomas Sieber, Pauline M. McNamee, Stefan Pfuhler, Carsten Goebel

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 159 KB

english, 2009

13

Development of a novel technique to quantify activity and localisation of the base excision repair protein OGG1 in individual cells and its induction by the pro-oxidant potassium bromate

Leda Mirbahai, Rachael M. Kershaw, Rosalind A. Meldrum, Nikolas J. Hodges

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 140 KB

english, 2009

14

Advancing the 3Rs : Exposure-driven risk assessment

Anna L. Rowbotham, Rosemary M. Gibson

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 74 KB

english, 2009

15

Impact of transporter-mediated uptake on statin-induced gene expression in human Huh7 cells

Faizah Sanat, Katharine Howe, Tanya Coleman, Alfred Thumser, Nick Plant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 125 KB

english, 2009

16

Potentiation of the cyotoxic effects of natural chemopreventative agents, ellagic acid and quercetin

Fiona Saunders, Manju Oommen, Ratchadawadee Lapjitkusol, Edward Amankwatia, Lauren Kaminski, Adele Swanson, Alastair Mitchell, Heather M. Wallace

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 93 KB

english, 2009

17

How does increasing cytotoxicity affect the accuracy of the GADD45a-GFP genotoxicity screening assay: A comparison of 4 different toxicity testing methods

Matthew Tate, Christopher Jagger, Nicholas Billinton, Paul Cahill, Adam Rabinowitz, Andrew Knight, Richard Walmsley

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 112 KB

english, 2009

18

Altered mRNA translation by miRNA species in cells resistant to doxorubicin toxicity

Joan Riley, Timothy W. Gant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 59 KB

english, 2009

19

An in vitro model for the prediction of chemical metabolism and toxicity

Shaohong Ding, Audrey Vardy, Clifford R. Elcombe, C. Roland Wolf

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 59 KB

english, 2009

20

Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue

Hayley Webb, Jonathan Duckworth, Paul Turnpenny, Iain Gardner, Dennis Smith, Kevin Park, Dominic Williams

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 71 KB

english, 2009

21

Characterisation of pesticide transport in neural cells

Katherine Betteley, Amy S. Windass, Elaine Mutch, Colin D.A. Brown, Faith M. Williams

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 55 KB

english, 2009

22

Role of PXR And FXR in the transcriptional regulation of Oatps

Laura C. Young, David E. Cowie, Richard J. Weaver, Gabrielle M. Hawksworth

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 65 KB

english, 2009

23

Increased expression of liver specific functional markers in primary cells grown in a 3D cell culture environment

Maaike E. Schutte, Alison Devonshire, Maria Bokhari, Carole Foy, Stefan Przyborski, Damian Marshall

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 49 KB

english, 2009

24

Effects of mono and di(n-butyl) phthalate on superoxide dismutase

Ganesh K. Prasanth, L.M. Divya, C. Sadasivan

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 498 KB

english, 2009

25

Assessment of Protein Allergenicity Following Systemic Exposure in Mice: Relationship with Immunogenicity

Rebecca J. Dearman, Ian Kimber

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 224 KB

english, 2009

26

Effect of a Red Meat Meal on Human Urinary Metabotype After Cruciferous Vegetable Consumption

William M. Edmands, Elaine Holmes, Nigel J. Gooderham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 133 KB

english, 2009

27

Mechanisms of Drug Hepatotoxicity in Man: Novel Insights Provided by the THLE-CYP Cell Panel

Mhairi L. Greer, Tim J.D. Smith, J. Gerry Kenna

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 123 KB

english, 2009

28

Intracellular Ca2+ Alteration Via Phospholipase C-Inositol Triphosphate And Mitochondrial-Caspase Dependent Pathways Mediate Cadmium-Induced Cell Death

Akeem O. Lawal, Elizabeth M. Ellis

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 256 KB

english, 2009

29

Role of miRNA Species and Altered mRNA Translation in Doxorubicin and Quinone Mediated Cardiotoxicity In vivo and In vitro

A.V. Pointon, J.D. Parry, K.M. Phillips, J. Riley, J. Luo, S.-D. Zhang, E.L. Taylor, J. Lyons, T.W. Gant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 188 KB

english, 2009

30

Differential Hepatic microRNA-mediated Translation in Two Independent Models of Erythropoietic Protoporphyria

Emma L. Taylor, Kate M. Phillips, Joan Riley, Shu-Dong Zhang, Timothy W. Gant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 55 KB

english, 2009

31

Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine

Abhishek Srivastava, Dominic P. Williams, James L. Maggs, Lu-Yun Lian, Mas Chaponda, Iain Gardner, Munir Pirmohamed, Kevin Park

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 68 KB

english, 2009

32

Lycopene: An antioxidant and radioprotector against γ-radiation-induced cellular damages in cultured human lymphocytes

M. Srinivasan, N. Devipriya, K.B. Kalpana, Venugopal P. Menon

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 737 KB

english, 2009

33

Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats

Abderrahim Nemmar, Subramanian Dhanasekaran, Javed Yasin, Hajer Ba-Omar, Mohamed A. Fahim, Elsadig E. Kazzam, Badreldin H. Ali

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 548 KB

english, 2009

34

Microarray analysis of gene expression in rat alveolar epithelial cells exposed to fractionated organic extracts of diesel exhaust particles

Seiichi Omura, Eiko Koike, Takahiro Kobayashi

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 472 KB

english, 2009

35

Editorial Board Members

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 38 KB

english, 2009

36

Special Issue

Journal:

Année:

2009

Fichier:

PDF, 84 KB

2009

37

Contents listing

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 46 KB

english, 2009

38

Investigation of regulation of receptor for advanced glycation end products (RAGE) in animal models of drug-induced liver injury

Craig Benson, Daniel Antoine, Christopher E. Goldring, Kevin Park, Dominic Williams

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 248 KB

english, 2009

39

Human constitutive androstane receptor (CAR) supports the hypertrophic but not the hyperplastic response to the murine non-genotoxic carcinogen phenobarbital (pb) in vivo

Clifford R. Elcombe, Jillian Ross, Nico Scheer, Anja Rode, C. Roland Wolf

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 161 KB

english, 2009

40

Phylogenetic analysis of the ATP-binding cassette super-family: Implications for the development of multiple drug resistance phenotype

Ciaran Fisher, Tanya Coleman, Nick Plant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 144 KB

english, 2009

41

Carcinogenic and non-carcinogenic doses of Phenobarbital cause distinct microrna profiles in male Fischer rats after 14 days of dietary exposure

Costas Koufaris, Jayne Wright, Richard Currie, Nigel J. Gooderham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 134 KB

english, 2009

42

PhIP induced deregulation of microRNA expression is consistent with its oestrogenic properties

Michael D. Papaioannou, Nigel J. Gooderham

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 155 KB

english, 2009

43

Differential transcription of miRNA species in hepatoxicity caused by novel ‘failed in development’ drugs

Kate M. Phillips, Emma L. Taylor, Laura Suter-Dick, InnoMed PredTox consortium, Timothy W. Gant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 87 KB

english, 2009

44

Sex differences in formic aciduria in Fischer 344 (F-344) rats and dose response in male F-344 rats exposed orally to trichloroethylene

Noreen Yaqoob, Nicola Dempster, Celia J. Reed, Edward A. Lock

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 77 KB

english, 2009

45

Transcriptional Regulation of Abcc1–6 (Multidrug Resistance Associated Protein 1–6) in Rat Hepatocytes

Lucy C.J. Ellis, Richard J. Weaver, Gabrielle M. Hawksworth

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 133 KB

english, 2009

46

In Silico Modelling of Drug Fate and Disposition

Samantha L. Forster, Steve R. Hood, Nick J. Plant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 305 KB

english, 2009

47

Connectivity Mapping for Early Toxicity Recognition Using the FP6 InnoMed PredTox Data

Shu-Dong Zhang, Joshua L. Smalley, Laura Suter-Dick, Timothy W. Gant

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 51 KB

english, 2009

48

Toxicological information on chemicals published in the Russian language: Contribution to REACH and 3Rs

Mariliis Sihtmäe, Henri-Charles Dubourguier, Anne Kahru

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 398 KB

english, 2009

49

Type 2 IP3 receptors are involved in uranyl acetate induced apoptosis in HEK 293 cells

Juraj Kopacek, Karol Ondrias, Barbora Sedlakova, Jana Tomaskova, Lucia Zahradnikova, Jan Sedlak, Zdena Sulova, Alexandra Zahradnikova, Jaromir Pastorek, Olga Krizanova

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2009

50

Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells

Helén Andersson, Elena Piras, Jemal Demma, Björn Hellman, Eva Brittebo

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 493 KB

english, 2009

51

Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats

Bernhard H. Monien, Carolin Müller, Nadiya Bakhiya, Claudia Donath, Heinz Frank, Albrecht Seidel, Hansruedi Glatt

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 393 KB

english, 2009