Volume 231; Issue 2-3

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Toxicology
Volume 231; Issue 2-3

Toxicology

Volume 231; Issue 2-3

1

Reduction and replacement—ECVAM's response to REACH

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 83 KB

english, 2007

2

Promoting reduction—A home office perspective

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 45 KB

english, 2007

3

Some effective approaches to the 3Rs in the regulatory testing of new industrial chemicals

Hannah L. Bembridge

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 51 KB

english, 2007

4

Exposure driven testing to minimize animal use

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 43 KB

english, 2007

5

Implementation of screening approaches to minimise animal use

Robert L. Guest

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 50 KB

english, 2007

6

Approaches to minimise animal use in inhalation toxicity studies

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 58 KB

english, 2007

7

Minimisation of dog use in the safety assessment of pharmaceuticals: Progress with the EFPIA/RSPCA/FRAME dog project

David Smith, Robert Combes, Annie Delaunois, Ruediger Hack, Lieve Lammens, Joerg Luft, Friedrich von Landenberg, Anna-Mette Paarup, Rudolf Pfister, Barry Phillips, Yvon Rabemampianina, Sue Sparrow, Cl

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 54 KB

english, 2007

8

Outcome of the ECVAM skin irritation validation study

Philip A. Botham

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 50 KB

english, 2007

9

Testing of biologicals: Reducing primate use

C. Ian Ragan, Kathryn L. Chapman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 43 KB

english, 2007

10

Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures

David Stevenson, Caroline Morgan, Lesley McLellan, M. Helen Grant

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2007

11

Stable HepG2 aggregates formed by levitation in an ultrasound standing wave trap: Cell adhesion dynamics and cytoskeletal reorganisation

Gareth Owain Edwards, Despina Bazou, Larisa A. Kuznetsova, W. Terence Coakley

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2007

12

A calculation of the starting dose for human exposure to a monoclonal antibody TGN1412

Andre E.M. McLean

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 56 KB

english, 2007

13

In silico modelling of skin sensitisation

C. MacKay, S. Bajaria, G. Shaver, K. Kudrycki, S. Ramanujan, T. Paterson, C. Friedrich, G. Maxwell, I. Jowsey, D. Lockley, F. Reynolds, J. Fentem

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 47 KB

english, 2007

14

Metabolism and toxicity of two new benzodiazepine-type antileishmanial agents in hepatocytes and macrophages

M. Dao Duong Thi, Rachel L. Clark, Simon P. Mackay, Alex B. Mullen, Justice N.A. Tettey, M. Helen Grant

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 205 KB

english, 2007

15

Involvement of reduced glutathione and glutathione reductase in the chronic toxicity of hexavalent chromium to monocytes in vitro

Vijay Krishna Raghunathan, Elizabeth M. Ellis, Justice N.A. Tettey, M. Helen Grant

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 171 KB

english, 2007

16

Covalent modifications of proteins by sensitisers—Far from a random event?

Maja Aleksic, Camilla K. Pease

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 57 KB

english, 2007

17

Genomic investigation of the metabolic competency of human cord blood-derived dendritic cells

Ruth U. Pendlington, Vicki Summerfield, Andrew White, Camilla K. Pease

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 58 KB

english, 2007

18

Development of the rotary cell culture system (RCCS) as a model for in vitro neurotoxicity studies

Raymond A. Ransley, Michael D. Coleman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 52 KB

english, 2007

19

Development of a neurotoxicity test-system using human post-mitotic, astrocytic and neuronal cell lines in co-culture

Elizabeth K. Woehrling, Eric J. Hill, Michael D. Coleman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 63 KB

english, 2007

20

Influence of formulation on the dermal absorption of pesticide actives at spray dilution concentrations

Gillian F. Aust, Simon Wilkinson, Michael Dunn, Richard Glass, Faith M. Williams

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 60 KB

english, 2007

21

Investigation of GFAP levels as a marker of toxicity in human glioma cell lines

Lindsay J. Holden, Michael D. Coleman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 50 KB

english, 2007

22

Vitic—A data source for (quantitative) structure–activity relationship modelling

Katharine A. Briggs

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 56 KB

english, 2007

23

What does a dermal acute toxicity study add to the information on a plant protection pesticide?

Hugh D. Thomas, Ian C. Dewhurst

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 56 KB

english, 2007

24

Chemical insult and toll-like receptor ligands: Synergistic effects on dendritic cells

Gavin Maxwell, Marie Cumberbatch, Craig Portsmouth, Kirsty Clelland, Carolin Schramm, Carl Westmoreland, David A. Basketter, Rebecca J. Dearman, Ian Kimber

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 59 KB

english, 2007

25

Reactivity assays for non-animal based prediction of skin sensitisation potential

Nora Aptula, David W. Roberts, T. Wayne Schultz, Camilla Pease

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 62 KB

english, 2007

26

Identification and manipulation of transglutaminase isoforms and activity for the detection of squamous metaplasia in tracheobronchial cells in vitro

Alison. C. Gray, Richard. H. Clothier, Julie. D. McLeod

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 54 KB

english, 2007

27

Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells

Cuifen Wang, Xudong Wu, Min Chen, Weigang Duan, Lixin Sun, Ming Yan, Luyong Zhang

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2007

28

Diphenyl ditelluride effect on embryo/fetal development in mice: Interspecies differences

Silvane Souza Roman, Alexandra Nava, Alexandre Marafon Favero, Simone Nardin Weis, Gilson Zeni, Joao B.T. Rocha, Cristina Wayne Nogueira

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 278 KB

english, 2007

29

EPO receptor, Bax and Bcl-xL expressions in murine erythropoiesis after cyclophosphamide treatment

Julián Antonio Juaristi, María Victoria Aguirre, Juan Santiago Todaro, Mirta Alba Alvarez, Nora Cristina Brandan

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 970 KB

english, 2007

30

Mouse model of paraquat-poisoned lungs and its gene expression profile

Masafumi Tomita, Toshiko Okuyama, Hironobu Katsuyama, Yoshie Miura, Yasumitsu Nishimura, Kazuo Hidaka, Takemi Otsuki, Takaki Ishikawa

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2007

31

Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: Possible implications for their mutagenic and carcinogenic effects

Nina E. Landvik, Morgane Gorria, Volker M. Arlt, Nana Asare, Anita Solhaug, Dominique Lagadic-Gossmann, Jørn A. Holme

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2007

32

Effect of fluoride intoxication on endometrial apoptosis and lipid peroxidation in rats: Role of vitamins E and C

Mehmet Guney, Baha Oral, Gulnur Take, Seren Gulsen Giray, Tamer Mungan

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2007

33

Editorial Board

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 46 KB

english, 2007

34

Special issue section title page

Journal:

Année:

2007

Fichier:

PDF, 46 KB

2007

35

Contents

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 40 KB

english, 2007

36

List of authors of the Proceedings of the Joint Meeting of The British Toxicology Society and The In Vito Toxicology Society and The UK NC3 Rs

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 75 KB

english, 2007

37

UK NC3Rs initiatives

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 76 KB

english, 2007

38

The European partnership for alternative approaches to animal testing

Cornelis Brekelmans

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 45 KB

english, 2007

39

Regulatory experience with the mouse local lymph node assay for skin sensitisation

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 55 KB

english, 2007

40

Challenging the regulatory requirement for conventional acute toxicity studies in pharmaceutical drug development

Sally Robinson, Deborah Ockert, Petet Stei, David Dreher, Kev Somers, Elizabeth Donald, Ann Lampo, Sophie Kervyn, Nigel Pickersgill, Vicente Nogues, Kamil Nahas, Mathias Festag, Pascale Brunel, Sally

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 48 KB

english, 2007

41

Development of a systems approach for the analysis of toxicogenomic data

Guy J. Warner, Yeyejide A. Adeleye, Trey Ideker, Christopher T. Workman, Daniel J. Scott

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 62 KB

english, 2007

42

An assessment of the performance of an automated scoring system (Cellomics) for the in vitro micronucleus assay in CHO-K1 cells

Andrew Scott, Sophie Malcomber, Sharon Maskell, Claire Moore, Sam Windebank, Dolores Diaz, Paul Carmichael

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 61 KB

english, 2007

43

Effect of arsenic on DNA damage, glutathione content, apoptosis and necrosis in HaCat cells

Ghazalla Benhusein, Elaine Mutch, Faith M. Williams

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 59 KB

english, 2007

44

Altered glucose homeostasis and oxidative impairment in pancreas of rats subjected to dimethoate intoxication

Vasudeva Kamath, P.S. Rajini

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 499 KB

english, 2007

45

Truncations of gelonin lead to a reduction in its cytotoxicity

Zhuoyu Li, Yanfeng Qu, Hanqing Li, Jingming Yuan

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 498 KB

english, 2007

46

The role of toxicokinetics in xylene-induced ototoxicity in the rat and guinea pig

F. Gagnaire, B. Marignac, V. Blachère, S. Grossmann, C. Langlais

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 639 KB

english, 2007

47

Linuron and carbaryl differentially impair baseline amino acid and bile salt olfactory responses in three salmonids

Keith B. Tierney, Peter S. Ross, Christopher J. Kennedy

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 890 KB

english, 2007

48

Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH

Thomas R. Zilz, Helen R. Griffiths, Michael D. Coleman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 374 KB

english, 2007

49

The initiation activity of norfloxacin does not result in the induction of hepatocellular tumors in rats

Tadashi Itoh, Mitsuyoshi Moto, Yuichi Kuroiwa, Hiroki Sakai, Kunitoshi Mitsumori

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 306 KB

english, 2007

50

Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)

Xinrong Chen, Jimei Zhang, Sharon M. Baker, Guangping Chen

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 674 KB

english, 2007