Volume 18; Issue 6

Organic Process Research & Development

Volume 18; Issue 6

1

Efficient Production of ( R )- o -Chloromandelic Acid by Recombinant Escherichia coli Cells Harboring Nitrilase from Burkholderia cenocepacia J2315

Wang, Hualei, Sun, Huihui, Gao, Wenyuan, Wei, Dongzhi

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 333 KB

english, 2014

2

Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines

Paul, Caroline E., Rodríguez-Mata, María, Busto, Eduardo, Lavandera, Iván, Gotor-Fernández, Vicente, Gotor, Vicente, García-Cerrada, Susana, Mendiola, Javier, de Frutos, Óscar, Collado, Iván

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 358 KB

english, 2014

3

Special Feature Biocatalysis: The Green Factor

Mahmoudian, Mahmoud

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 115 KB

english, 2014

4

Identification, Synthesis, and Strategy for the Reduction of Potential Impurities Observed in Dabigatran Etexilate Mesylate Processes

Zheng, Yong-Yong, Shen, Cheng-Wu, Zhu, Mei-Yu, Zhou, Yi-Meng, Li, Jian-Qi

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 482 KB

english, 2014

5

Development of a Practical, Biocatalytic Reduction for the Manufacture of ( S )-Licarbazepine Using an Evolved Ketoreductase

Modukuru, Naga K., Sukumaran, Joly, Collier, Steven J., Chan, Ann Shu, Gohel, Anupam, Huisman, Gjalt W., Keledjian, Raquel, Narayanaswamy, Karthik, Novick, Scott J., Palanivel, S. M., Smith, Derek, We

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2014

6

Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ-Secretase Modulator

Shen, Ruichao, Fuller, Nathan O., Osswald, Gerd, Austin, Wesley F., Hubbs, Jed L., Haag, Dieter, Kovacs, Janos, Creaser, Steffen P., Findeis, Mark A., Ives, Jeffrey L., Bronk, Brian S.

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 612 KB

english, 2014

7

Some Items of Interest to Process R&D Chemists and Engineers

Zhao, Wenyi, Zhao, Dongbo, Alves de Souza, Rodrigo Octavio Mendonça, Guizzetti, Sylvain, Raghuraman, Arjun, Knight, John

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 987 KB

english, 2014

8

A Scalable Route to the SMO Receptor Antagonist SEN826: Benzimidazole Synthesis via Enhanced in Situ Formation of the Bisulfite–Aldehyde Complex

Betti, Matteo, Genesio, Eva, Marconi, Guido, Sanna Coccone, Salvatore, Wiedenau, Paul

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 2.37 MB

english, 2014

9

Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B Polymerase: Phenylboronate as a Transient Protecting Group

Mayes, Benjamin A., Arumugasamy, Jeevanandam, Baloglu, Erkan, Bauer, David, Becker, Alan, Chaudhuri, Narayan, Latham, G. Mark, Li, Jie, Mathieu, Steve, McGarry, F. Patrick, Rosinovsky, Elodie, Stewart

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 429 KB

english, 2014

10

Practical and Scalable Synthesis of a Benzonitrile Derivative via Palladium-Catalyzed Cyanation with Potassium Ferrocyanide

Utsugi, Masayuki, Ozawa, Hiroki, Toyofuku, Eiji, Hatsuda, Masanori

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 790 KB

english, 2014

11

A Challenging Synthesis of the Highly Functionalized Echinocandin ASP9726: A Successor of Micafungin

Yoshida, Shinya, Hayashida, Joji, Morinaga, Yasuhiro, Mizobata, Shoji, Okada, Akihiro, Kawai, Kazumi, Tanoue, Shinjirou, Nakata, Tomohide, Kitayama, Minoru, Ohigashi, Atsushi, Matsuura, Mitsutaka, Tak

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2014

12

Biocatalytic and Fermentative Production of α,ω-Bifunctional Polymer Precursors

Schaffer, Steffen, Haas, Thomas

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2014

13

Optimization and Scale-up of a Bioreduction Process for Preparation of Ethyl ( S )-4-Chloro-3-hydroxybutanoate

Pan, Jiang, Zheng, Gao-Wei, Ye, Qin, Xu, Jian-He

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 284 KB

english, 2014

14

Development of a Biocatalytic Process to Prepare ( S )- N -Boc-3-hydroxypiperidine

Ju, Xin, Tang, Yuanyuan, Liang, Xiaoliang, Hou, Maoqi, Wan, Zhonghui, Tao, Junhua

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 518 KB

english, 2014

15

The Role of Diastereomer Impurity in Oiling-Out during the Resolution of trans -4-Methyl-2-piperidine Carboxylic Ethyl Ester Enantiomers by Crystallization

Ren, Riju, Sun, Dengqiong, Wei, Tingting, Zhang, Shixin, Gong, Junbo

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 5.77 MB

english, 2014

16

Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli

Dascier, Dimitri, Kambourakis, Spiros, Hua, Ling, Rozzell, J. David, Stewart, Jon D.

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 698 KB

english, 2014

17

Cost-Effective, Efficient, Scalable, and Safe

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 111 KB

english, 2014

18

Enzyme-Catalyzed Hydrolysis of Bicycloheptane and Cyclobutene Diesters to Monoesters

Guo, Zhiwei, Wong, Michael Kwok Y., Hickey, Matthew R., Patel, Bharat P., Qian, Xinhua, Goswami, Animesh

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 223 KB

english, 2014

19

Biphasic Catalysis with Disaccharide Phosphorylases: Chemoenzymatic Synthesis of α- d -Glucosides Using Sucrose Phosphorylase

De Winter, Karel, Desmet, Tom, Devlamynck, Tim, Van Renterghem, Lisa, Verhaeghe, Tom, Pelantová, Helena, Křen, Vladimír, Soetaert, Wim

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 232 KB

english, 2014

20

Processing of o -Halobenzoates by Toluene Dioxygenase. The Role of the Alkoxy Functionality in the Regioselectivity of the Enzymatic Dihydroxylation Reaction

Froese, Jordan, Endoma-Arias, Mary Ann A., Hudlicky, Tomas

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 482 KB

english, 2014

21

Combining Metabolic Pathway Design and Retrosynthetic Planning for the Design of a Novel Semisynthetic Manufacturing Scheme for Paclitaxel

Yadav, Vikramaditya G.

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 645 KB

english, 2014

22

Correction to Semisynthetic Artemisinin, the Chemical Path to Industrial Production

Turconi, Joël, Griolet, Frédéric, Guevel, Ronan, Oddon, Gilles, Villa, Roberto, Geatti, Andrea, Hvala, Massimo, Rossen, Kai, Göller, Rudolf, Burgard, Andreas

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 109 KB

english, 2014

23

Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ-Secretase Modulator

Fuller, Nathan O., Hubbs, Jed L., Austin, Wesley F., Shen, Ruichao, Ives, Jeffrey, Osswald, Gerd, Bronk, Brian S.

Journal:

Organic Process Research & Development

Année:

2014

Langue:

english

Fichier:

PDF, 736 KB

english, 2014