Campagne de collecte 15 septembre 2024 – 1 octobre 2024 C'est quoi, la collecte de fonds?

Volume 13; Issue 5

Organic Process Research & Development

Volume 13; Issue 5

1

Development of a Practical Synthesis of the Progesterone Receptor Antagonist 4-{[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy}-2,6-dimethylbenzonitrile

Bradley, Paul A., de Koning, Pieter D., Johnson, Patrick S., Lecouturier, Yann C., McManus, David J., Robin, Aurelie, Underwood, Toby J.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 246 KB

english, 2009

2

Aqueous Process Chemistry: The Preparation of Aryl Sulfonyl Chlorides

Hogan, Philip J., Cox, Brian G.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 550 KB

english, 2009

3

An Improved Procedure for Preparation and Isolation of Cephalosporin Antibiotic: Cefozopran as Free Base

Tewari, Neera, Rai, Bishwa Prakash, Mohammad, Kallimulla, Nizar, Hashim, Prasad, Mohan

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 112 KB

english, 2009

4

Development of a Practical Large-Scale Synthesis of Denagliptin Tosylate

Boehler, Emily, Irdam, Erwin, Osterhout, Martin H., Patterson, Daniel E., Powers, Jeremiah D., LeBlanc, Michael, Sharkey, Tyler

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 996 KB

english, 2009

5

Development of a Practical Synthesis of a Purine Nucleoside Phosphorylase Inhibitor: BCX-4208

Kamath, Vivekanand P., Juarez-Brambila, Jesus J., Morris, Christopher B., Winslow, Christopher D., Morris, Philip E.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 247 KB

english, 2009

6

A New Industrial Process for 10-Methoxyiminostilbene: Key Intermediate for the Synthesis of Oxcarbazepine

Singh, Harnam, Gupta, Nitin, Kumar, Pramod, Dubey, Sushil K., Sharma, Pawan K.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 248 KB

english, 2009

7

On Scale Up of Organic Reactions in Closed Vessel Microwave Systems

Strauss, Christopher R.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 510 KB

english, 2009

8

Large-Scale Synthesis of a Selective Inhibitor of the Norepinephrine Transporter: Mechanistic Aspects of Conversion of Indolinone Diol to Indolinone Aminoalcohol and Process Implications

Alimardanov, Asaf, Gontcharov, Alexander, Nikitenko, Antonia, Chan, Anita W., Ding, Zhixian, Ghosh, Mousumi, Levent, Mahmut, Raveendranath, Panolil, Ren, Jianxin, Zhou, Maotang, Mahaney, Paige E., McC

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 272 KB

english, 2009

9

Microreactor-Based Synthesis of Molecularly Imprinted Polymer Beads Used for Explosive Detection

Roeseling, Dirk, Tuercke, Tobias, Krause, Horst, Loebbecke, Stefan

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2009

10

An Improved and Scalable Process for the Synthesis of Ezetimibe: An Antihypercholesterolemia Drug †

Sasikala, C. H. V. A., Reddy Padi, Pratap, Sunkara, Vishnuvardhan, Ramayya, Pattabhi, Dubey, P. K., Bhaskar Rao Uppala, Venkata, Praveen, Cherukupally

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 144 KB

english, 2009

11

Optimizing the Deprotection of the Amine Protecting p -Methoxyphenyl Group in an Automated Microreactor Platform

Koch, Kaspar, van Weerdenburg, Bram J. A., Verkade, Jorge M. M., Nieuwland, Pieter J., Rutjes, Floris P. J. T., van Hest, Jan C. M.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 169 KB

english, 2009

12

Continuous Production of the Diazomethane Precursor N -Methyl- N- nitroso- p- toluenesulfonamide: Batch Optimization and Transfer into a Microreactor Setup

Struempel, Michael, Ondruschka, Bernd, Stark, Annegret

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 808 KB

english, 2009

13

An Improved Process for the Production of Rabeprazole Sodium Substantially Free from the Impurities §

Ramchandra Reddy, Pingili, Himabindu, Vurimidi, Jaydeepkumar, Lilakar, Madhusudhan Reddy, Ganta, Vijaya Kumar, Jonnalagadda, Mahesh Reddy, Ghanta

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 281 KB

english, 2009

14

Continuous Flow Nitration of Benzaldehyde

Kulkarni, Amol A., Kalyani, Vishwanath S., Joshi, Ramesh A., Joshi, Rohini R.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 287 KB

english, 2009

15

An Investigation on Key Parameters that Influence the Synthesis of ( S )-(+)- N , N -Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine: A Key Intermediate for Duloxetine

Suthrapu, Sashikanth, Sripathi, Somaiah, Veeramalla, Raju, Bojja, Ramachandra Reddy, Karnati, Venugopal Reddy

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 152 KB

english, 2009

16

Selective Hydrogenation of 2-Methyl-3-butyne-2-ol in a Wall-Coated Capillary Microreactor with a Pd 25 Zn 75 /TiO 2 Catalyst

Rebrov, Evgeny V., Klinger, Ekaterina A., Berenguer-Murcia, Angel, Sulman, Esther M., Schouten, Jaap C.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 447 KB

english, 2009

17

Design and Performance of a Microstructured PEEK Reactor for Continuous Poly- l -leucine-Catalysed Chalcone Epoxidation

Kee, Suet-Ping, Gavriilidis, Asterios

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 358 KB

english, 2009

18

Book Review of Modern Pharmaceutics Modern Pharmaceutics , 5th ed. Edited by Alexander T. FlorenceandJuergen Siepmann . Informa Healthcare : London . 2009 . £215. 2 Volumes. ISBN 978-142006566-4 and 978-142006564-0 .

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

19

Regulatory Highlights for March−August 2009

Robinson, Derek

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 69 KB

english, 2009

20

Intensification of the Capillary-Based Kolbe−Schmitt Synthesis from Resorcinol by Reactive Ionic Liquids, Microwave Heating, or a Combination Thereof

Benaskar, Faysal, Hessel, Volker, Krtschil, Ulrich, Löb, Patrick, Stark, Annegret

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 2.79 MB

english, 2009

21

Safety Advantages of On-Site Microprocesses

Ebrahimi, Fatemeh, Kolehmainen, Eero, Turunen, Ilkka

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 134 KB

english, 2009

22

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, Pfeiffer, Matthew, Zlota, Andrei A., Laird, Trevor

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 3.65 MB

english, 2009

23

Book Review of Theilheimer’s Synthetic Methods of Organic Chemistry Theilheimer’s Synthetic Methods of Organic Chemistry . Edited by G. Tozer-Hotchkiss . Karger Publishing : Basel, Switzerland . 2009 . Volume 74. 457 + xix pages. $790.00. ISBN 978-3805-59235-2 .

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

24

Book Review of Polymorphism in Pharmaceutical Solids Polymorphism in Pharmaceutical Solids , 2nd ed. Edited by Harry G. Brittain . Informa Healthcare : London, New York . 2009 : 640 + xi pages. £150. ISBN 978-142007321-8 .

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

25

Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis

Tanaka, Katsunori, Fukase, Koichi

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 3.72 MB

english, 2009

26

Book Review of Organic Reactions Organic Reactions . S. E. Denmark , Ed. Wiley : Hoboken NJ . 2008 . Vol. 72. 704 + ix pages . £93.50. ISBN 978-0-470-42374-5.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

27

Comprehensive Toxicology Risk Assessment for Genotoxic Impurities

Bercu, Joel P., Callis, Courtney M.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 39 KB

english, 2009

28

Flow Uniformity in Deep Microchannel Reactor under High Throughput Conditions

Sotowa, Ken-Ichiro, Sugiyama, Shigeru, Nakagawa, Keizo

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 562 KB

english, 2009

29

From Batch to Flow Processing: Racemization of N -Acetylamino Acids under Microwave Heating

Dressen, Mark H. C. L., van de Kruijs, Bastiaan H. P., Meuldijk, Jan, Vekemans, Jef A. J. M., Hulshof, Lumbertus A.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2009

30

IMRET 10: Process Intensification via New Reactor Technologies and New Ways of Processing

Hessel, Volker, Besser, Ron

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 37 KB

english, 2009

31

The Effect of Water and Phenol on the Chiral Oxazaborolidine-Catalyzed Reduction of a Prostaglandin Enone Derivative

Ohta, Chisa, Kuwabe, Shin-itsu, Shiraishi, Tai, Ohuchida, Shuichi, Seko, Takuya

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 142 KB

english, 2009

32

Utilization of Sequential Palladium-Catalyzed Cross-Coupling Reactions in the Stereospecific Synthesis of Trisubstituted Olefins

Houpis, Ioannis N., Schils, Didier, Nettekoven, Ulrike, Schnyder, Anita, Bappert, Erhart, Weerts, Koen, Canters, Martine, Vermeulen, Wim A. A.

Journal:

Organic Process Research & Development

Année:

2009

Fichier:

PDF, 28 KB

2009

33

A Review of U.S. Patents in the Field of Organic Process Development Published During April and May 2009

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2009

34

Book Review of Validation of Pharmaceutical Processes, edited by J. Agalloco and F. J. Carleton Validation of Pharmaceutical Processes , 3rd ed. By J. Agallocoand F. J. Carleton . Informa Healthcare : New York . 2008 . 737 + xvi pages. ISBN 978-0-8493-7055-7 . £165.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

35

Book Review of Pharmaceutical Substances, Syntheses, Patents, Applications Pharmaceutical Substances, Syntheses, Patents, Applications, 5th ed. by A. Kleeman , J. Engel , B. Kutscher and D. Reichert . Thieme : Stuttgart , 2009 . ISBN 978-3-13-558405-8 . Hardback. pp 1722 (including indices).

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

36

Metal Contamination: When the Contaminant May Be the Actual Catalyst

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 48 KB

english, 2009

37

Online Analysis of Flowing Streams Using Microflow HPLC

Welch, Christopher J., Gong, Xiaoyi, Cuff, James, Dolman, Sarah, Nyrop, Jason, Lin, Fiona, Rogers, Hallena

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 922 KB

english, 2009

38

Investigation on the Formation and Hydrolysis of N , N -Dimethylcarbamoyl Chloride (DMCC) in Vilsmeier Reactions Using GC/MS as the Analytical Detection Method

Stare, Martina, Laniewski, Krzysztof, Westermark, Andreas, Sjögren, Magnus, Tian, Wei

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 252 KB

english, 2009

39

An Ozonolysis−Reduction Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices

Hübner, Sandra, Bentrup, Ursula, Budde, Uwe, Lovis, Kai, Dietrich, Thomas, Freitag, Andreas, Küpper, Lukas, Jähnisch, Klaus

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2009

40

Extending Ru-BINAP Catalyst Life and Separating Products from Catalyst Using Membrane Recycling

Nair, Dinesh, Wong, Hau-To, Han, Shejiao, Vankelecom, Ivo F. J., White, Lloyd S., Livingston, Andrew G., Boam, Andrew T.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 936 KB

english, 2009

41

An Improved and Scaleable Preparation of 7-Amino-3-vinylcephem-4-carboxylic acid

Chao, Mingyong, Hao, Aiyou

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 352 KB

english, 2009

42

Scalable Enantioseparation of Amino Acid Derivatives Using Continuous Liquid−Liquid Extraction in a Cascade of Centrifugal Contactor Separators

Schuur, Boelo, Hallett, Andrew J., Winkelman, Jozef G. M., de Vries, Johannes G., Heeres, Hero J.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 931 KB

english, 2009

43

Response to the Comments by Bercu and Callis on our communication “Controlling the Genotoxins Ethyl Chloride and Methyl Chloride Formed During the Preparation of Amine Hydrochloride Salts from Solutions of Ethanol and Methanol” [ Org. Process Res. Dev . 2009 , 13 , 786−791; DOI: 10.1021/op9000737]

Haney, Brian P., Mason, Paul, Anderson, Neal G.

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 39 KB

english, 2009

44

Book Review of Thermal Safety of Chemical Processes: Risk Assessment and Process Design Thermal Safety of Chemical Processes: Risk Assessment and Process Design . By Francis Stoessel. Wiley-VCH : Weinheim . 2008 . 374 pp. Euro 99.00. ISBN: 978-3-527-31712-7 .

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

45

Ionic Liquids on Demand in Continuous Flow

Wilms, Daniel, Klos, Johannes, Kilbinger, Andreas F. M., Löwe, Holger, Frey, Holger

Journal:

Organic Process Research & Development

Année:

2009

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2009