Volume 1; Issue 5

ACS Medicinal Chemistry Letters

Volume 1; Issue 5

1

Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4

Bevan, Douglas E., Martinko, Alexander J., Loram, Lisa C., Stahl, Joshua A., Taylor, Frederick R., Joshee, Sampada, Watkins, Linda R., Yin, Hang

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 2.47 MB

english, 2010

2

Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

Xu, Lianhong, Liu, Hongtao, Murray, Bernard P., Callebaut, Christian, Lee, Melody S., Hong, Allen, Strickley, Robert G., Tsai, Luong K., Stray, Kirsten M., Wang, Yujin

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1009 KB

english, 2010

3

Allosteric IGF-1R Inhibitors

Heinrich, Timo, Grädler, Ulrich, Böttcher, Henning, Blaukat, Andree, Shutes, Adam

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 4.76 MB

english, 2010

4

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases

Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J., Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg,

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2010

5

In This Issue

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2010

6

Optimization of an Albumin-Binding Prodrug of Doxorubicin That Is Cleaved by Prostate-Specific Antigen

Elsadek, Bakheet, Graeser, Ralph, Warnecke, André, Unger, Clemens, Saleem, Tahia, El-Melegy, Nagla, Madkor, Hafez, Kratz, Felix

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2010

7

Synthesis of a 68 Ga-Labeled Peptoid−Peptide Hybrid for Imaging of Neurotensin Receptor Expression in Vivo

Maschauer, Simone, Einsiedel, Jürgen, Hocke, Carsten, Hübner, Harald, Kuwert, Torsten, Gmeiner, Peter, Prante, Olaf

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2010

8

Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2- a ]-Pyrazine Core

Yu, Tao, Tagat, Jayaram R., Kerekes, Angela D., Doll, Ronald J., Zhang, Yonglian, Xiao, Yushi, Esposite, Sara, Belanger, David B., Curran, Patrick J., Mandal, Amit K., Siddiqui, M. Arshad, Shih, Neng-

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2010

9

N -Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ-Opioid Receptor Ligands

Frankowski, Kevin J., Ghosh, Partha, Setola, Vincent, Tran, Thuy B., Roth, Bryan L., Aubé, Jeffrey

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2010

10

Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists

Southers, James A., Bauman, Jonathan N., Price, David A., Humphries, Paul S., Balan, Gayatri, Sagal, John F., Maurer, Tristan S., Zhang, Yan, Oliver, Robert, Herr, Michael, Healy, David R., Li, Mei, K

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

11

Docking to Erlotinib Off-Targets Leads to Inhibitors of Lung Cancer Cell Proliferation with Suitable in Vitro Pharmacokinetics

Li, Liwei, Li, Jing, Khanna, May, Jo, Inha, Baird, Jason P., Meroueh, Samy O.

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2010