Volume 20; Issue 4

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Molecular Therapy
Volume 20; Issue 4

Molecular Therapy

Volume 20; Issue 4

1

Treating Tumors With a Vaccinia Virus Expressing IFNβ Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity

Wang, Liang-Chuan S, Lynn, Rachel C, Cheng, Guanjun, Alexander, Edward, Kapoor, Veena, Moon, Edmund K, Sun, Jing, Fridlender, Zvi G, Isaacs, Stuart N, Thorne, Stephen H

Journal:

Molecular Therapy

Année:

2011

Langue:

english

Fichier:

PDF, 650 KB

english, 2011

2

Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

Zirger, Jeffrey M, Puntel, Mariana, Bergeron, Josee, Wibowo, Mia, Moridzadeh, Rameen, Bondale, Niyati, Barcia, Carlos, Kroeger, Kurt M, Liu, Chunyan, Castro, Maria G

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2012

3

Preclinical Corrective Gene Transfer in Xeroderma Pigmentosum Human Skin Stem Cells

Warrick, Emilie, Garcia, Marta, Chagnoleau, Corinne, Chevallier, Odile, Bergoglio, Valérie, Sartori, Daniela, Mavilio, Fulvio, Angulo, Jaime F, Avril, Marie-Françoise, Sarasin, Alain, Larcher, Fernand

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 772 KB

english, 2012

4

Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment

Yuan, Jinyun, Wang, Jianbin, Crain, Karen, Fearns, Colleen, Kim, Kenneth A, Hua, Kevin L, Gregory, Philip D, Holmes, Michael C, Torbett, Bruce E

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 525 KB

english, 2012

5

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

Monteleone, Giovanni, Fantini, Massimo C, Onali, Sara, Zorzi, Francesca, Sancesario, Giulia, Bernardini, Sergio, Calabrese, Emma, Viti, Francesca, Monteleone, Ivan, Biancone, Livia, Pallone, Francesco

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 385 KB

english, 2012

6

Myxoma Virus Sensitizes Cancer Cells to Gemcitabine and Is an Effective Oncolytic Virotherapeutic in Models of Disseminated Pancreatic Cancer

Wennier, Sonia Tusell, Liu, Jia, Li, Shoudong, Rahman, Masmudur M., Mona, Mahmoud, McFadden, Grant

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 879 KB

english, 2012

7

Retroviral Integrations in Gene Therapy Trials

Biasco, Luca, Baricordi, Cristina, Aiuti, Alessandro

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 232 KB

english, 2012

8

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters

He, Bo, Tang, Ru-hang, Weisleder, Noah, Xiao, Bin, Yuan, Zhenhua, Cai, Chuanxi, Zhu, Hua, Lin, Peihui, Qiao, Chunping, Li, Jianbin, Mayer, Christina, Li, Juan, Ma, Jianjie, Xiao, Xiao

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 869 KB

english, 2012

9

Co-administration With the Pharmacological Chaperone AT1001 Increases Recombinant Human α-Galactosidase A Tissue Uptake and Improves Substrate Reduction in Fabry Mice

Benjamin, Elfrida R, Khanna, Richie, Schilling, Adriane, Flanagan, John J, Pellegrino, Lee J, Brignol, Nastry, Lun, Yi, Guillen, Darlene, Ranes, Brian E, Frascella, Michelle, Soska, Rebecca, Feng, Jes

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 864 KB

english, 2012

10

The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Lau

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 750 KB

english, 2012

11

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

Kim, Il-Doo, Shin, Joo-Hyun, Kim, Seung-Woo, Choi, Sunghyun, Ahn, Junseong, Han, Pyung-Lim, Park, Jong-Sang, Lee, Ja-Kyeong

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2012

12

The AAV Vector Toolkit: Poised at the Clinical Crossroads

Asokan, Aravind, Schaffer, David V, Jude Samulski, R

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 225 KB

english, 2012

13

Adenovirus-mediated E2-EPF UCP Gene Transfer Prevents Autoamputation in a Mouse Model of Hindlimb Ischemia

Lim, Jung Hwa, Shin, Hyo Jung, Park, Kyeong-Su, Lee, Chan Hee, Jung, Cho-Rok, Im, Dong-Soo

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2012

14

Combined mTOR Inhibition and OX40 Agonism Enhances CD8+ T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

Bassett, Jennifer D, Swift, Stephanie L, VanSeggelen, Heather, Hammill, Joanne A, McGray, AJ Robert, Evelegh, Carole, Wan, Yonghong, Bramson, Jonathan L

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 701 KB

english, 2012

15

HIV Develops Indirect Cross-resistance to Combinatorial RNAi Targeting Two Distinct and Spatially Distant Sites

Shah, Priya S, Pham, Nhung P, Schaffer, David V

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 631 KB

english, 2012

16

A Water-Soluble Coelenterazine for Sensitive In Vivo Imaging of Coelenterate Luciferases

Morse, Danielle, Tannous, Bakhos A

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 486 KB

english, 2012

17

Do Cell-Penetrating Peptides Actually “Penetrate” Cellular Membranes?

Palm-Apergi, Caroline, Lönn, Peter, Dowdy, Steven F

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 908 KB

english, 2012

18

Seeing Eye to Eye With Gene Therapy

Herzog, Roland W

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 449 KB

english, 2012

19

BioKnife, a uPA Activity-dependent Oncolytic Sendai Virus, Eliminates Pleural Spread of Malignant Mesothelioma via Simultaneous Stimulation of uPA Expression

Morodomi, Yosuke, Yano, Tokujiro, Kinoh, Hiroaki, Harada, Yui, Saito, Satoru, Kyuragi, Ryoichi, Yoshida, Kumi, Onimaru, Mitsuho, Shoji, Fumihiro, Yoshida, Tsukihisa, Ito, Kensaku, Shikada, Yasunori, M

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 541 KB

english, 2012

20

Progress in the Development of Hepatitis C Virus Vaccines

Ertl, Hildegund CJ

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 836 KB

english, 2012

21

mRNA Leapfrogs DNA to Show Promise for Therapeutic Gene Transfer

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 897 KB

english, 2012

22

SHAPE-directed Discovery of Potent shRNA Inhibitors of HIV-1

Low, Justin T, Knoepfel, Stefanie A, Watts, Joseph M, ter Brake, Olivier, Berkhout, Ben, Weeks, Kevin M

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 407 KB

english, 2012

23

Stanniocalcin-1 Rescued Photoreceptor Degeneration in Two Rat Models of Inherited Retinal Degeneration

Roddy, Gavin W, Rosa Jr, Robert H, Youn Oh, Joo, Ylostalo, Joni H, Bartosh, Thomas J, Choi, Hosoon, Lee, Ryang Hwa, Yasumura, Douglas, Ahern, Kelly, Nielsen, Gregory, Matthes, Michael T, LaVail, Matth

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 655 KB

english, 2012

24

In This Issue

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2012

25

Research Highlights

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 462 KB

english, 2012