Volume 9; Issue 10

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ACS Chemical Biology
Volume 9; Issue 10

ACS Chemical Biology

Volume 9; Issue 10

1

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

Nakagawa, Akito, Lui, Francine E., Wassaf, Dina, Yefidoff-Freedman, Revital, Casalena, Dominick, Palmer, Michelle A., Meadows, Jacqueline, Mozzarelli, Andrea, Ronda, Luca, Abdulmalik, Osheiza, Bloch,

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2014

2

Potent Antimalarial Activity of Acriflavine In Vitro and In Vivo

Dana, Srikanta, Prusty, Dhaneswar, Dhayal, Devender, Gupta, Mohit Kumar, Dar, Ashraf, Sen, Sobhan, Mukhopadhyay, Pritam, Adak, Tridibesh, Dhar, Suman Kumar

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2014

3

A Rapid SNAP-Tag Fluorogenic Probe Based on an Environment-Sensitive Fluorophore for No-Wash Live Cell Imaging

Liu, Tao-Kai, Hsieh, Pei-Ying, Zhuang, Yu-De, Hsia, Chi-Yang, Huang, Chi-Ling, Lai, Hsiu-Ping, Lin, Hung-Sheung, Chen, I-Chia, Hsu, Hsin-Yun, Tan, Kui-Thong

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.94 MB

english, 2014

4

Microbiota of Healthy Corals Are Active against Fungi in a Light-Dependent Manner

Moree, Wilna J., McConnell, Oliver J., Nguyen, Don D., Sanchez, Laura M., Yang, Yu-Liang, Zhao, Xiling, Liu, Wei-Ting, Boudreau, Paul D., Srinivasan, Jayashree, Atencio, Librada, Ballesteros, Javier,

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 4.08 MB

english, 2014

5

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans -Acyltransferase Polyketide Synthase Enoyl-isomerase

Gay, Darren C., Spear, Philip J., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.67 MB

english, 2014

6

Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication

Mukherjee, Sourav, Weiner, Warren S., Schroeder, Chad E., Simpson, Denise S., Hanson, Alicia M., Sweeney, Noreena L., Marvin, Rachel K., Ndjomou, Jean, Kolli, Rajesh, Isailovic, Dragan, Schoenen, Fran

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.37 MB

english, 2014

7

Platinum-RNA Modifications Following Drug Treatment in S. cerevisiae Identified by Click Chemistry and Enzymatic Mapping

Osborn, Maire F., White, Jonathan D., Haley, Michael M., DeRose, Victoria J.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 5.09 MB

english, 2014

8

Labeled EF-Tus for Rapid Kinetic Studies of Pretranslocation Complex Formation

Liu, Wei, Kavaliauskas, Darius, Schrader, Jared M., Poruri, Kiran, Birkedal, Victoria, Goldman, Emanuel, Jakubowski, Hieronim, Mandecki, Wlodek, Uhlenbeck, Olke C., Knudsen, Charlotte R., Goldman, Yal

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 495 KB

english, 2014

9

Resurfaced Shape Complementary Proteins That Selectively Bind the Oncoprotein Gankyrin

Chapman, Alex M., McNaughton, Brian R.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.71 MB

english, 2014

10

Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

Chen, Gang, Koellhoffer, Jayne F., Zak, Samantha E., Frei, Julia C., Liu, Nina, Long, Hua, Ye, Wei, Nagar, Kaajal, Pan, Guohua, Chandran, Kartik, Dye, John M., Sidhu, Sachdev S., Lai, Jonathan R.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.68 MB

english, 2014

11

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

Leonidova, Anna, Gasser, Gilles

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2014

12

Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli

Hameed P, Shahul, Manjrekar, Praveena, Chinnapattu, Murugan, Humnabadkar, Vaishali, Shanbhag, Gajanan, Kedari, Chaitanyakumar, Mudugal, Naina Vinay, Ambady, Anisha, de Jonge, Boudewijn L.M., Sadler, C

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.80 MB

english, 2014

13

Discovery of a Highly Selective Caspase-3 Substrate for Imaging Live Cells

Vickers, Chris J., González-Páez, Gonzalo E., Wolan, Dennis W.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.64 MB

english, 2014

14

Antimicrobial Peptide Resistance of Vibrio cholerae Results from an LPS Modification Pathway Related to Nonribosomal Peptide Synthetases

Henderson, Jeremy C., Fage, Christopher D., Cannon, Joe R., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T., Trent, M. Stephen

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 5.78 MB

english, 2014

15

Asymmetrical Distribution of Choline Phospholipids Revealed by Click Chemistry and Freeze-Fracture Electron Microscopy

Iyoshi, Shohei, Cheng, Jinglei, Tatematsu, Tsuyako, Takatori, Sho, Taki, Masayasu, Yamamoto, Yukio, Salic, Adrian, Fujimoto, Toyoshi

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 6.39 MB

english, 2014

16

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

Adams, Drew J., Ito, Daisuke, Rees, Matthew G., Seashore-Ludlow, Brinton, Puyang, Xiaoling, Ramos, Alex H., Cheah, Jaime H., Clemons, Paul A., Warmuth, Markus, Zhu, Ping, Shamji, Alykhan F., Schreiber

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.31 MB

english, 2014

17

In This Issue

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 941 KB

english, 2014

18

Simultaneous Detection of Distinct Ubiquitin Chain Topologies by 19 F NMR

Shekhawat, Sujan S., Pham, Grace H., Prabakaran, Jyothiprashanth, Strieter, Eric R.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 5.43 MB

english, 2014

19

Transition-State Analysis of 2- O -Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1

Hirsch, Brett M., Burgos, Emmanuel S., Schramm, Vern L.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2014

20

Selective Inhibition of Initiator versus Executioner Caspases Using Small Peptides Containing Unnatural Amino Acids

Vickers, Chris J., González-Páez, Gonzalo E., Litwin, Kevin M., Umotoy, Jeffrey C., Coutsias, Evangelos A., Wolan, Dennis W.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2014

21

Chemical Modulation of Mutant mGlu 1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Brogan, John T., Hopkins, Corey R., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Bubser, Michael, Daniels, J. Scott,

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 4.29 MB

english, 2014

22

Spotlights

Dahlmann, Heidi A., Underwood, Jason G., Webb, Sarah A.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 818 KB

english, 2014

23

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

Douse, Christopher H., Maas, Sabrina J., Thomas, Jemima C., Garnett, James A., Sun, Yunyun, Cota, Ernesto, Tate, Edward W.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 4.10 MB

english, 2014

24

Introducing Our Authors

Powell, Rachelle

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 7.01 MB

english, 2014

25

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

Elshahawi, Sherif I., Ramelot, Theresa A., Seetharaman, Jayaraman, Chen, Jing, Singh, Shanteri, Yang, Yunhuang, Pederson, Kari, Kharel, Madan K., Xiao, Rong, Lew, Scott, Yennamalli, Ragothaman M., Mil

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 6.14 MB

english, 2014

26

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

Olson, David E., Udeshi, Namrata D., Wolfson, Noah A., Pitcairn, Carol Ann, Sullivan, Eric D., Jaffe, Jacob D., Svinkina, Tanya, Natoli, Ted, Lu, Xiaodong, Paulk, Joshiawa, McCarren, Patrick, Wagner,

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.92 MB

english, 2014

27

High-Throughput Screening System To Identify Small Molecules That Induce Internalization and Degradation of HER2

Isa, Masayuki, Asanuma, Daisuke, Namiki, Shigeyuki, Kumagai, Kazuo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Hirose, Kenzo

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 915 KB

english, 2014

28

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

Mannini, Benedetta, Mulvihill, Estefania, Sgromo, Caterina, Cascella, Roberta, Khodarahmi, Reza, Ramazzotti, Matteo, Dobson, Christopher M., Cecchi, Cristina, Chiti, Fabrizio

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.51 MB

english, 2014

29

Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

Jackson, Paul J. M., James, Colin H., Jenkins, Terence C., Rahman, Khondaker M., Thurston, David E.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2014

30

Boron Dipyrromethene As a Fluorescent Caging Group for Single-Photon Uncaging with Long-Wavelength Visible Light

Umeda, Nobuhiro, Takahashi, Hironori, Kamiya, Mako, Ueno, Tasuku, Komatsu, Toru, Terai, Takuya, Hanaoka, Kenjiro, Nagano, Tetsuo, Urano, Yasuteru

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2014

31

Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl

Daeffler, Kristina N.-M., Lester, Henry A., Dougherty, Dennis A.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.75 MB

english, 2014

32

Redesigning Human 2′-Deoxycytidine Kinase Enantioselectivity for l -Nucleoside Analogues as Reporters in Positron Emission Tomography

Muthu, Pravin, Chen, Hannah X., Lutz, Stefan

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2014

33

Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria

Gerdt, Joseph P., Blackwell, Helen E.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.91 MB

english, 2014

34

RNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking

Dolgosheina, Elena V., Jeng, Sunny C. Y., Panchapakesan, Shanker Shyam S., Cojocaru, Razvan, Chen, Patrick S. K., Wilson, Peter D., Hawkins, Nancy, Wiggins, Paul A., Unrau, Peter J.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 3.37 MB

english, 2014