Volume 44; Issue 6

Journal of Medicinal Chemistry

Volume 44; Issue 6

1

Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides

Thomas, James B., Herault, Xavier M., Rothman, Richard B., Atkinson, Robert N., Burgess, Jason P., Mascarella, S. Wayne, Dersch, Christina M., Xu, Heng, Flippen-Anderson, Judith L., George, Clifford F

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 259 KB

english, 2001

2

Enantiospecific Synthesis and Pharmacological Evaluation of a Series of Super-Potent, Conformationally Restricted 5-HT2A/2C Receptor Agonists

Chambers, James J., Kurrasch-Orbaugh, Deborah M., Parker, Matthew A., Nichols, David E.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 108 KB

english, 2001

3

High-Throughput Permeability pH Profile and High-Throughput Alkane/Water log P with Artificial Membranes

Wohnsland, Frank, Faller, Bernard

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 116 KB

english, 2001

4

A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Robl, Jeffrey A., Sulsky, Richard, Sun, Chong-Qing, Simpkins, Ligaya M., Wang, Tammy, Dickson, John K., Chen, Ying, Magnin, David R., Taunk, Prakash, Slusarchyk, William A., Biller, Scott A., Lan, Shi

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 78 KB

english, 2001

5

Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity

Clerici, Francesca, Pocar, Donato, Guido, Maddalena, Loche, Antonella, Perlini, Vincenzo, Brufani, Mario

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 99 KB

english, 2001

6

Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression

Stewart, Andrew O., Bhatia, Pramila A., McCarty, Catherine M., Patel, Meena V., Staeger, Michael A., Arendsen, David L., Gunawardana, Indrani W., Melcher, Laura M., Zhu, Gui-Dong, Boyd, Steven A., Fry

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 354 KB

english, 2001

7

Pyrido[2,3- d ]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases.

Barvian, Mark, Boschelli, Diane H., Cossrow, Jennifer, Dobrusin, Ellen, Fattaey, Ali, Fritsch, Alex, Fry, David, Harvey, Patricia, Keller, Paul, Garrett, Michelle, La, Frances, Leopold, Wilbur, McNama

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 15 KB

english, 2001

8

New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines

Arzel, Erwan, Rocca, Patrick, Grellier, Philippe, Labaeïd, Mehdi, Frappier, François, Guéritte, Françoise, Gaspard, Christiane, Marsais, Francis, Godard, Alain, Quéguiner, Guy

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 202 KB

english, 2001

9

Inhibition of Heme Detoxification Processes Underlies the Antimalarial Activity of Terpene Isonitrile Compounds from Marine Sponges

Wright, Anthony D., Wang, Huiqin, Gurrath, Marion, König, Gabriele M., Kocak, Gulcan, Neumann, Gregory, Loria, Paul, Foley, Michael, Tilley, Leann

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 443 KB

english, 2001

10

Bisphosphonates Inhibit the Growth of Trypanosoma b rucei , Trypanosoma c ruzi , Leishmania d onovani , Toxoplasma g ondii , and Plasmodium f alciparum : A Potential Route to Chemotherapy

Martin, Michael B., Grimley, Joshua S., Lewis, Jared C., Heath, Huel T., Bailey, Brian N., Kendrick, Howard, Yardley, Vanessa, Caldera, Aura, Lira, Renee, Urbina, Julio A., Moreno, Silvia N. J., Docam

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 117 KB

english, 2001

11

Molecular Modeling Studies of the Akt PH Domain and Its Interaction with Phosphoinositides

Rong, Suo-Bao, Hu, Youhong, Enyedy, Istvan, Powis, Garth, Meuillet, Emmanuelle J., Wu, Xiongwu, Wang, Renxiao, Wang, Shaomeng, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 588 KB

english, 2001

12

Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, and N -Hydroxysulfonamides Inhibit Both These Zinc Enzymes

Scozzafava, Andrea, Supuran, Claudiu T.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 14 KB

english, 2001

13

Comparative Binding Energy (COMBINE) Analysis of Influenza Neuraminidase−Inhibitor Complexes

Wang, Ting, Wade, Rebecca C.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 136 KB

english, 2001

14

Pharmacophore Analysis of the Nuclear Oxysterol Receptor LXRα

Spencer, Thomas A., Li, Dansu, Russel, Jonathon S., Collins, Jon L., Bledsoe, Randy K., Consler, Thomas G., Moore, Linda B., Galardi, Cristin M., McKee, David D., Moore, John T., Watson, Michael A., P

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 413 KB

english, 2001

15

Investigation of the Selectivity of Oxymorphone- and Naltrexone-Derived Ligands via Site-Directed Mutagenesis of Opioid Receptors: Exploring the ‘Address' Recognition Locus

Metzger, Thomas G., Paterlini, M. Germana, Ferguson, David M., Portoghese, Philip S.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 348 KB

english, 2001

16

Structure−Activity Relationship Studies of 4-[2-(Diphenylmethoxy)ethyl]-1-benzylpiperidine Derivatives and Their N-Analogues: Evaluation of Behavioral Activity of O- and N-Analogues and Their Binding to Monoamine Transporters

Dutta, Aloke K., Fei, Xiang-Shu, Beardsley, Patrick M., Newman, Jennifer L., Reith, Maarten E. A.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 144 KB

english, 2001

17

A Potent, Nonpeptidyl 1 H -Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor

DeVita, Robert J., Walsh, Thomas F., Young, Jonathan R., Jiang, Jinlong, Ujjainwalla, Feroze, Toupence, Richard B., Parikh, Mamta, Huang, Song X., Fair, Jason A., Goulet, Mark T., Wyvratt, Matthew J.,

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 81 KB

english, 2001

18

Solid-Phase Synthesis and Inhibitory Effects of Some Pyrido[1,2- c ]pyrimidine Derivatives on Leukocyte Functions and Experimental Inflammation

Molina, Pedro, Aller, Enrique, Lorenzo, Ángeles, López-Cremades, Pablo, Rioja, Inmaculada, Ubeda, Amalia, Terencio, M Carmen, Alcaraz, M José

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 48 KB

english, 2001

19

α 2 Adrenoceptor Agonists as Potential Analgesic Agents. 3. Imidazolylmethylthiophenes

Boyd, Robert E., Rasmussen, C. Royce, Press, Jeffery B., Raffa, Robert B., Codd, Ellen E., Connelly, Charlene D., Li, Quan S., Martinez, Rebecca P., Lewis, Martin A., Almond, Harold R., Reitz, Allen B

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 278 KB

english, 2001

20

Solid-Phase Synthesis and Combinatorial Technologies By Pierfausto Seneci. Wiley-Interscience, New York. 2000. xii + 637 pp. 16 × 24 cm. ISBN 0471331953. $109.95.

Patrick, Kennerly S.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 12 KB

english, 2001