Volume 37; Issue 26

Journal of Medicinal Chemistry

Volume 37; Issue 26

1

Ligands for Brain Cholinergic Channel Receptors: Synthesis and in Vitro Characterization of Novel Isoxazoles and Isothiazoles as Bioisosteric Replacements for the Pyridine Ring in Nicotine

Garvey, David S., Wasicak, James T., Elliott, Richard L., Lebold, Suzanne, Hettinger, Ann-Marie, Carrera, George M., Lin, Nan-Horng, He, Yun, Holladay, Mark W.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1994

2

Structural Evolution and Pharmacology of a Novel Series of Triacid Angiotensin II Receptor Antagonists

Palkowitz, Alan D., Steinberg, Mitchell I., Thrasher, K. Jeff, Reel, Jon K., Hauser, Kenneth L., Zimmerman, Karen M., Wiest, Sally A., Whitesitt, Celia A., Simon, Richard L.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.80 MB

english, 1994

3

2,4-Diamino-5-chloroquinazoline Analogs of Trimetrexate and Piritrexim: Synthesis and Antifolate Activity

Rosowsky, Andre, Mota, Clara E., Wright, Joel E., Queener, Sherry F.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1994

4

Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Chang, Linda L., Ashton, Wallace T., Flanagan, Kelly L., Chen, Tsing-Bau, O'Malley, Stacey S., Zingaro, Gloria J., Siegl, Peter K. S., Kivlighn, Salah D., Lotti, Victor J.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.99 MB

english, 1994

5

A Bioactive Fullerene Peptide

Toniolo, Claudio, Bianco, Alberto, Maggini, Michele, Scorrano, Gianfranco, Prato, Maurizio, Marastoni, Mauro, Tomatis, Roberto, Spisani, Susanna, Palu, Giorgio, Blair, Edward D.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 613 KB

english, 1994

6

Identification, Synthesis, and Characterization of a Unique Class of N-Methyl-D-aspartate Antagonists. The 6,11-Ethanobenzo[b]quinolizinium Cation

Mallamo, John P., Earley, William G., Kumar, Virendra, Subramanyam, Chakrapani, Dority, John A. Jr., Miller, Matthew S., DeHaven-Hudkins, Diane L., Ault, Brian, Herrmann, John L.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 2.62 MB

english, 1994

7

Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents

Nugent, Richard A., Schlachter, Stephen T., Murphy, Megan, Dunn, Colin J., Staite, Nigel D., Galinet, Louise A., Shields, Sharon K., Wu, Haiyan, Aspar, Danielle G., Richard, Karen A.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 741 KB

english, 1994

8

Synthesis and Anticonvulsant Activities of .alpha.-Acetamido-N-benzylacetamide Derivatives Containing an Electron-Deficient .alpha.-Heteroaromatic Substituent

Bardel, Patrick, Bolanos, Antoinette, Kohn, Harold

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 659 KB

english, 1994

9

The Discovery of Novel, Structurally Diverse Protein Kinase C Agonists through Computer 3D-Database Pharmacophore Search. Molecular Modeling Studies

Wang, Shaomeng, Zaharevitz, Daniel W., Sharma, Rajiv, Marquez, Victor E., Lewin, Nancy E., Du, Linh, Blumberg, Peter M., Milne, G. W. A.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.28 MB

english, 1994

10

A Conformationally Defined 6-s-trans-Retinoic Acid Isomer: Synthesis, Chemopreventive Activity, and Toxicity

Vaezi, Michael F., Alam, Muzaffar, Sani, Brahma P., Rogers, Tina S., Simpson-Herren, Linda, Wille, John J., Hill, Donald L., Doran, Thomas I., Brouillette, Wayne J., Muccio, Donald D.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 2.07 MB

english, 1994

11

N-(Acyloxyalkyl)pyridinium Salts as Soluble Prodrugs of a Potent Platelet Activating Factor Antagonist

Davidsen, Steven K., Summers, James B., Albert, Daniel H., Holms, James H., Heyman, H. Robin, Magoc, Terrance J., Conway, Richard G., Rhein, David A., Carter, George W.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 866 KB

english, 1994

12

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

Wieland, Heike A., Lueddens, Hartmut

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 614 KB

english, 1994

13

Structure of a Covalent DNA Minor Groove Adduct with a Pyrrolobenzodiazepine Dimer: Evidence for Sequence-Specific Interstrand Crosslinking

Jenkins, Terence C., Hurley, Laurence H., Neidle, Stephen, Thurston, David E.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.40 MB

english, 1994

14

Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs

Erion, Mark D., Tan, Jenny, Wong, Mary, Jeng, Arco Y.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.72 MB

english, 1994

15

.kappa. Opioid Receptor Selective Affinity Labels: Electrophilic Benzeneacetamides as .kappa.-Selective Opioid Antagonists

Chang, An-Chih, Takemori, Akira E., Ojala, William H., Gleason, William B., Portoghese, Philip S.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.73 MB

english, 1994

16

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 159 KB

english, 1994

17

Book Reviews

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 470 KB

english, 1994

18

Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones

Angelastro, Michael R., Baugh, Larry E., Bey, Philippe, Burkhart, Joseph P., Chen, Teng-Man, Durham, Sherrie L., Hare, C. Michelle, Huber, Edward W., Janusz, Michael J.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 2.13 MB

english, 1994

19

Pentamidine Congeners. 2. 2-Butene-Bridged Aromatic Diamidines and Diimidazolines as Potential Anti-Pneumocystis carinii Pneumonia Agents

Donkor, Isaac O., Tidwell, Richard R., Jones, Susan K.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 394 KB

english, 1994

20

Derivatives of 4-(2'-Methoxyphenyl)-1-[2'-(N-2''-pyridinyl-p-iodobenzamido)ethyl]piperazine (p-MPPI) as 5-HT1A Ligands

Zhuang, Zhi-Ping, Kung, Mei-Ping, Chumpradit, Sumalee, Mu, Mu, Kung, Hank F.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 507 KB

english, 1994

21

A Novel and Useful Descriptor for Hydrophobicity, Partition Coefficient Micellar-Water, and Its Application to a QSAR Study of Antiplatelet Agents

Tanaka, Akito, Nakamura, Katsuhiko, Nakanishi, Isao, Fujiwara, Hideaki

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 469 KB

english, 1994