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Volume 37; Issue 2

Journal of Medicinal Chemistry

Volume 37; Issue 2

1

3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors

Hunt, Cecilia A., Mallorga, Pierre J., Michelson, Stuart R., Schwam, Harvey, Sondey, John M., Smith, Robert L., Sugrue, Michael F., Shepard, Kenneth L.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.65 MB

english, 1994

2

Novel cAMP PDE III inhibitors: imidazo[4,5-b]pyridin-2(3H)-ones and thiazolo[4,5-b]pyridin-2(3H)-ones and their analogs

Kuo, Gee Hong, Singh, Baldev, Bacon, Edward R., Robinson, Shaughnessy, Fritz, Richard K., Lesher, George Y., Kumar, Virendra, Dority, John A., Reuman, Michael

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 928 KB

english, 1994

3

Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors

Borchardt, R. T., Fisher, J. F., Islam, I., Ng, K. Y., Chong, K. T., McQuade, T. J., Hui, J. O., Wilkinson, K. F., Rush, B. D., Ruwart, M. J.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.53 MB

english, 1994

4

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity

Unangst, Paul C., Connor, David T., Cetenko, Wiaczeslaw A., Sorenson, Roderick J., Kostlan, Catherine R., Sircar, Jagadish C., Wright, Clifford D., Schrier, Denis J., Dyer, Richard D.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 891 KB

english, 1994

5

Adenosine deaminase inhibitors. Synthesis and biological evaluation of 4-amino-1-[2(S)-hydroxy-3(R)-nonyl]-1H-imidazo[4,5-c]pyridine [3-deaza-(+)-EHNA] and certain C1' derivatives

Harriman, Geraldine C. B., Abushanab, Elie, Stoeckler, Johanna D.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 556 KB

english, 1994

6

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

Bouffard, F. Aileen, Zambias, Robert A., Dropinski, James F., Balkovec, James M., Hammond, Milton L., Abruzzo, George K., Bartizal, Kenneth F., Marrinan, Jean A., Kurtz, Myra B.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 520 KB

english, 1994

7

.alpha.-Spirocyclopentyl- and .alpha.-spirocyclopropyl-.gamma.-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant .alpha.,.alpha.-disubstituted .gamma.-butyrolactones

Peterson, Eileen M., Xu, Kun, Holland, Katherine D., McKeon, Ann C., Rothman, Steven M., Ferrendelli, James A., Covey, Douglas F.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 2.33 MB

english, 1994

8

Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases

Oleksyszyn, Jozef, Boduszek, Bogdan, Kam, Chih-Min, Powers, James C.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 878 KB

english, 1994

9

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

Howarth, Nicola M., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 389 KB

english, 1994

10

Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits

Mohamadi, Fariborz, Spees, Michael M., Staten, Gilbert S., Marder, Philip, Kipka, Julia K., Johnson, David A., Boger, Dale L., Zarrinmayeh, Hamideh

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.48 MB

english, 1994

11

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 174 KB

english, 1994

12

A new approach to the design of .sigma.-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine-related polyamines at .sigma.-1 and .sigma.-2 receptor subtypes

de Costa, Brian R., He, Xiao-shu, Dominguez, Celia, Cutts, Janet, Williams, Wanda, Bowen, Wayne D.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1994

13

Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers

Roufos, Ioannis, Hays, Sheryl J., Dooley, David J., Schwarz, Roy D., Campbell, Gregory W., Probert, Albert W.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 907 KB

english, 1994

14

Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus

Elliott, Richard L., Kopecka, Hana, Bennett, Michael J., Shue, Youe Kong, Craig, Richard, Lin, Chun Wel, Bianchi, Bruce R., Miller, Thomas R., Witte, David G.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 694 KB

english, 1994

15

Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist

Reddy, N. L., Hu, Lain-Yen, Cotter, R. E., Fischer, J. B., Wong, W. J., McBurney, R. N., Weber, E., Holmes, D. L., Wong, S. T.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 946 KB

english, 1994

16

Antitumor agents. 144. New .gamma.-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II

Zhou, Xiao Ming, Lee, Kenneth Jiann Hung, Cheng, Ji, Wu, Shihn Sheng, Chen, Hong Xing, Guo, Xin, Cheng, Yung Chi, Lee, Kuo Hsiung

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 595 KB

english, 1994

17

Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7

Pavo, Imre, Slaninova, Jirina, Fahrenholz, Falk, Klein, Uwe

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 671 KB

english, 1994

18

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport

Smith, Amos B., Hirschmann, Ralph, Pasternak, Alexander, Akaishi, Ryouichi, Guzman, Mark C., Jones, David R., Keenan, Terence P., Sprengeler, Paul A., Darke, Paul L.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 922 KB

english, 1994