Volume 34; Issue 9

Journal of Medicinal Chemistry

Volume 34; Issue 9

1

Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine

Harden, Fiona A., Quinn, Ronald J., Scammells, Peter J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1991

2

Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

Rosenberg, Howard E., Wadsworth, Harry J., Wyman, Paul, Orlek, Barry S., Blaney, Frank E., Brown, Frank, Clark, Michael S. G., Hadley, Michael S., Hatcher, John, Riley, Graham J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 2.09 MB

english, 1991

3

Anxiolytic properties of certain annelated [1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones

Rovinski, Stephen L., Amrick, Caryl L., Loo, Patricia S., Murphy, Deborah, Neale, Robert F., Wilson, Douglas E., Francis, John E., Bennett, Debra A., Hyun, James L.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1991

4

2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors

Saari, Walfred S., Hoffman, Jacob M., Wai, John S., Fisher, Thorsten E., Rooney, Clarence S., Smith, Anthony M., Thomas, Craig M., Goldman, Mark E., O'Brien, Julie A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 495 KB

english, 1991

5

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones - inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation

Meanwell, Nicholas A., Roth, Herbert R., Smith, Edward C. R., Wedding, Donald L., Wright, J. J. Kim, Fleming, J. Stuart, Gillespie, Elizabeth

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1991

6

New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives

Bayer, Herbert, Batzl, Christine, Hartman, Rolf W., Mannschreck, Albrecht

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 855 KB

english, 1991

7

NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding

Petros, A. M., Gampe, R. T., Gemmecker, G., Neri, P., Holzman, T. F., Edalji, R., Hochlowski, J., Jackson, M., McAlpine, J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 999 KB

english, 1991

8

Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides

Peterson, Mark L., Vince, Robert

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.66 MB

english, 1991

9

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Mantlo, Nathan B., Chakravarty, Prasun K., Ondeyka, Debra L., Siegl, Peter K. S., Chang, Raymond S., Lotti, Victor J., Faust, Kristie A., Schorn, Terry W., Chen, Tsing Bau

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 548 KB

english, 1991

10

N6,9-Disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor

Thompson, Robert D., Secunda, Sherrie, Daly, John W., Olsson, Ray A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 759 KB

english, 1991

11

Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors

Andrea, T. A., Kalayeh, Hooshmand

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 2.05 MB

english, 1991

12

Benzylated 1,2,3-triazoles as anticoccidiostats

Bochis, Richard J., Chabala, John C., Harris, Ellwood, Peterson, Louis H., Barash, Louis, Beattie, Thomas, Brown, Jeannette E., Graham, Donald W., Waksmunski, Frank S.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1991

13

Nitroheterocycle reduction as a paradigm for intramolecular catalysis of drug delivery to hypoxic cells

Firestone, Albert, Mulcahy, R. Timothy, Borch, Richard F.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 369 KB

english, 1991

14

The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogs

Dyson, Michael R., Coe, Paul L., Walker, Richard T.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 697 KB

english, 1991

15

Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2(TxA2)antagonists. Semicarbazone .omega.-chains

Misra, Raj N., Brown, Baerbel R., Han, Wen Ching, Harris, Don N., Hedberg, Anders, Webb, Maria L., Hall, Steven E.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1991

16

(Phenylmethoxy)phenyl derivatives of w-oxo- and w-tetrazolylalkanoic acids and related tetrazoles. Synthesis and evaluation as leukotriene D4 receptor antagonists

Dillard, Robert D., Hahn, Richard A., McCullough, Doris, Carr, F. Patrick, Rinkema, Lynn E., Roman, Carlos R., Fleisch, Jerome H.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.65 MB

english, 1991

17

Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate

Noble, Martin E. M., Verlinde, Christophe L. M. J., Groendijk, Hillie, Kalk, Kor H., Wierenga, Rik K., Hol, Wim G. J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.83 MB

english, 1991

18

Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid

Li, Shu Wen, Nair, M. G., Edwards, Donna M., Kisliuk, R. L., Gaumont, Y., Dev, I. K., Duch, D. S., Humphreys, J., Smith, G. K., Ferone, Robert

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1991

19

Synthesis, ligand binding, QSAR, and CoMFA study of 3.beta.-(p-substituted phenyl)tropane-2.beta.-carboxylic acid methyl esters

Carroll, F. Ivy, Gao, Yigong, Rahman, M. Abdur, Abraham, Philip, Parham, Karol, Lewin, Anita H., Boja, John W., Kuhar, Michael J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 2.32 MB

english, 1991

20

Dopamine autoreceptor agonists as potential antipsychotics. 3. 6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine

Caprathe, Bradley W., Jaen, Juan C., Wise, Lawrence D., Heffner, Thomas G., Pugsley, Thomas A., Meltzer, Leonard T., Parvez, Masood

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.48 MB

english, 1991

21

My odyssey in drug discovery

DeStevens, George

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 741 KB

english, 1991

22

Dual-action cephalosporins: cephalosporin 3'-quinolone carbamates

Albrecht, Harry A., Beskid, George, Georgopapadakou, Nafsika H., Keith, Dennis D., Konzelmann, Frederick M., Pruess, David L., Rossman, Pamela L., Wei, Chung Chen, Christenson, James G.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1991

23

Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogs

Davey, David D., Erhardt, P. W., Cantor, E. H., Greenberg, S. S., Ingebretsen, W. R., Wiggins, J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 779 KB

english, 1991

24

Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors

Shearer, Barry G., Sullivan, James P., Carter, J. Paul, Mathew, Rose M., Waid, Phillip, Connor, Jane R., Patch, Raymond J., Burch, Ronald M.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 477 KB

english, 1991

25

Potential antitumor agents. 63. Structure-activity relationships for side-chain analogs of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid

Rewcastle, Gordon W., Atwell, Graham J., Baguley, Bruce C., Boyd, Maruta, Thomsen, Lindy L., Zhuang, Li, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1991

26

C-Glycosidic analogs of lipid A and lipid X: synthesis and biological activities

Vyplel, Hermann, Scholz, Dieter, Macher, Ingolf, Schindlmaier, Karl, Schuetze, Eberhard

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1991

27

Studies on uricosuric diuretics. 4. Three-dimensional structure-activity relationships and receptor mapping of (aryloxy)acetic acid diuretics

Koga, Hiroshi, Sato, Haruhiko, Dan, Takashi, Aoki, Bunya

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 3.22 MB

english, 1991

28

Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists

Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Tufano, Michael D., Bianchi, Bruce R., Miller, Thomas R., Witte, David G., Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 837 KB

english, 1991

29

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Weber, Ann E., Halgren, Thomas A., Doyle, John J., Lynch, Robert J., Siegl, Peter K. S., Parsons, William H., Greenlee, William J., Patchett, Arthur A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 2.12 MB

english, 1991

30

Pregnanes that bind to the digitalis receptor: synthesis of 14-hydroxy-5.beta.,14.beta.-pregnane glycosides from digitoxin and digitoxigenin

Templeton, John F., Setiloane, Peter, Kumar, V. P. Sashi, Yan, Yulan, Zeglam, Talal H., LaBella, Frank S.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 571 KB

english, 1991

31

Spatial requirements of the sodium channel binding site for class I antiarrhythmics as derived from the crystal structures of 4-substituted 2,6-bis(1-pyrrolidinylmethyl)phenols

Glowka, Marek L., Dargie, Robin L., Codding, Penelope W.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 936 KB

english, 1991

32

Monoterpenic fragment analogs of aplasmomycin as potential antimalarials

Balu, N., Thomas, Jacob V., Bhat, Sujata V.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 386 KB

english, 1991

33

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 155 KB

english, 1991

34

A selective, reversible, competitive inhibitor of monoamine oxidase A containing no nitrogen, with negligible potentiation of tyramine-induced blood pressure rise

Harfenist, Morton, McGee, Daniel P. C., White, Helen L.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 380 KB

english, 1991

35

Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects

Fukuto, Jon M., Kumagai, Yoshito, Cho, Arthur K.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 862 KB

english, 1991

36

Nucleosides and nucleotides. 100. 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabinofuranosylcytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside

Matsuda, Akira, Nakajima, Yuki, Azuma, Atsushi, Tanaka, Motohiro, Sasaki, Takuma

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 434 KB

english, 1991

37

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

Robl, Jeffrey A., Duncan, Laurelee A., Pluscec, Jelka, Karanewsky, Donald S., Gordon, Eric M., Ciosek, Carl P., Rich, Lois C., Dehmel, Viviane C., Slusarchyk, Dorothy A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.72 MB

english, 1991

38

Synthesis and biological activity of sinefungin analogs

Blanchard, Pierre, Dodic, Nerina, Fourrery, Jean Louis, Lawrence, Francoise, Mouna, Abdel Malek, Robert-Gero, Malka

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 821 KB

english, 1991

39

Structure-activity relationships of estrogenic ligands: synthesis and evaluation of (17.alpha.,20E)- and (17.alpha.,20Z)-21-halo-19-norpregna-1,3,5(10),20-tetraene-3,17.beta.-diols

Napolitano, Elio, Fiaschi, Rita, Hanson, Robert N.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 759 KB

english, 1991

40

Book Reviews

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 173 KB

english, 1991

41

Modification of the enkephalin "message" with an artificial polycationic C-terminus

Jacobson, Alan R., Tam, S. William, Sayre, Lawrence M.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 863 KB

english, 1991

42

Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679

DeSolms, S. Jane, Giuliani, Elizabeth A., Guare, James P., Vacca, Joseph P., Sanders, William M., Graham, Samuel L., Wiggins, J. Mark, Darke, Paul L., Sigal, Irving S.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 772 KB

english, 1991