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Volume 32; Issue 6

Journal of Medicinal Chemistry

Volume 32; Issue 6

1

Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype .gamma.-aminobutyric acid prodrug to lactam and .gamma.-aminobutyric acid type metabolites

Wall, G. Michael, Baker, John K.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1989

2

Folate analogs. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds

Patil, Sharadbala D., Jones, Cecil, Nair, M. G., Galivan, J., Maley, F., Kisliuk, R. L., Gaumont, Y, Duch, David, Ferone, Robert

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 862 KB

english, 1989

3

6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents

Lobbestael, Sandra J., Pavia, Michael R., Taylor, Charles P.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 753 KB

english, 1989

4

1-(2-Aminoethyl)-6-aryl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines with diuretic and natriuretic activity

Hester, Jackson B., Ludens, James H., Emmert, D. Edward, West, Bruce E.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 854 KB

english, 1989

5

Synthesis and tumor uptake of 5-bromine-82- and 5-iodine-131-labeled 5-halo-1-(2-fluoro-2-deoxy-.beta.-D-ribofuranosyl)uracils

Mercer, John R., Xu, Li Hua, Knaus, Edward E., Wiebe, Leonard I.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 792 KB

english, 1989

6

Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors

Rizzi, James P., Schnur, Rodney C., Hutson, Nancy J., Kraus, Kenneth G., Kelbaugh, Paul R.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1989

7

Thromboxane A2 synthetase inhibitors. 2. Syntheses and activities of tetrahydronaphthalene and indane derivatives

Kanao, Munefumi, Watanabe, Yoshifumi, Kimura, Youichi, Saegusa, Junji, Yamamoto, Kenjiro, Kanno, Hideyuki, Kanaya, Naoaki, Kubo, Hideo, Ashida, Shinichiro, Ishikawa, Fumiyoshi

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1989

8

Phencyclidine-like effects of tetrahydroisoquinolines and related compounds

Gray, Nancy M., Cheng, Brian K., Mick, Stephen J., Lair, Cecelia M., Contreras, Patricia C.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 982 KB

english, 1989

9

Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-.beta.-carbolines

Dodd, Robert H., Ouannes, Catherine, Robert-Gero, Malka, Potier, Pierre

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 689 KB

english, 1989

10

The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity

New, James S., Christopher, William L., Yevich, Joseph P., Butler, Rhett, Schlemmer, R. Francis, VanderMaelen, Cam P., Cipollina, Joseph A.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1989

11

Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1

Yamato, Masatoshi, Takeuchi, Yasuo, Hashigaki, Kuniko, Ikeda, Yuji, Chang, Ming Rong, Takeuchi, Kyoko, Matsushima, Mayumi, Tsuruo, Takashi, Tashiro, Tazuko

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.43 MB

english, 1989

12

Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore

Erhardt, Paul W., Hagedorn, Alfred A., Davey, David, Pease, Cynthia A., Venepalli, Bhaskar R., Griffin, Carl W., Gomez, Robert P., Wiggins, Jay R., Ingebretsen, William R.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.24 MB

english, 1989

13

Acid-sensitive latent inhibitors for proteolytic enzymes: synthesis and characterization

Silver, Marc S., Haskell, John H.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 929 KB

english, 1989

14

New 1,4-dihydropyridine derivatives combining calcium antagonism and .alpha.-adrenolytic properties

Marciniak, Gilbert, Delgado, Antonio, Leclerc, Gerard, Velly, Jeanne, Decker, Nicole, Schwartz, Jean

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 812 KB

english, 1989

15

Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements

Harbeson, Scott L., Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 2.08 MB

english, 1989

16

Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions

Shamim, Mah T., Ukena, Dieter, Padgett, William L., Daly, John W.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1002 KB

english, 1989

17

Novel indolecarboxamidotetrazoles as potential antiallergy agents

Unangst, Paul C., Connor, David T., Stabler, S. Russell, Weikert, Robert J., Carethers, Mary E., Kennedy, John A., Thueson, David O., Chestnut, James C., Adolphson, Richard L., Conroy, M. C.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 922 KB

english, 1989

18

Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids

Muchowski, Joseph M., Galeazzi, Edvige, Greenhouse, Robert, Guzman, Angel, Perez, Virginia, Ackerman, Neil, Ballaron, Silveria A., Rovito, Joseph R., Tomolonis, Albert J.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 781 KB

english, 1989

19

Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides

Fujimoto, Roger A., Boxer, Jerome, Jackson, Robert H., Simke, John P., Neale, Robert F., Snowhill, Elaine W., Barbaz, Beverly J., Williams, Michael, Sills, Matthew A.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.87 MB

english, 1989

20

Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogs of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol)

Rogers, Gary A., Parsons, Stanley M., Anderson, D. C., Nilsson, Lena M., Bahr, Ben A., Kornreich, Wayne D., Kaufman, Rose, Jacobs, Robert S., Kirtman, Bernard

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.91 MB

english, 1989

21

Cyclic carbamate analogs of pilocarpine

Sauerberg, Per, Chen, June, WoldeMussie, Elizabeth, Rapoport, Henry

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 691 KB

english, 1989

22

2-Haloaporphines as potent dopamine agonists

Ramsby, Sten, Neumeyer, John L., Grigoriadis, Dimitri, Seeman, Philip

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 553 KB

english, 1989

23

Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives

Amemiya, Yoshiya, Terada, Atsusuke, Wachi, Kazuyuki, Miyazawa, Hachio, Hatakeyama, Naoko, Matsuda, Keiichi, Oshima, Takeshi

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1989

24

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 160 KB

english, 1989

25

Book Reviews

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1989

26

N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase

Nagasawa, Herbert T., Elberling, James A., DeMaster, Eugene G., Shirota, Frances N.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 819 KB

english, 1989

27

Synthesis of novel 5-fluoro analogs of norfloxacin and ciprofloxacin

Moran, Daniel B., Ziegler, Carl B., Dunne, Theresa S., Kuck, Nydia A., Lin, Yang I

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 779 KB

english, 1989

28

Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent

Shindo, Hirohisa, Takada, Susumu, Murata, Shunji, Eigyo, Masami, Matsushita, Akira

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 683 KB

english, 1989

29

Darmstoff analogs. 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle

Marx, Michael H., Wiley, Robert A., Satchell, D. G., Maguire, M. Helen

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 533 KB

english, 1989

30

Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Nair, M. G., Murthy, B. R., Patil, Sharadbala D., Kisliuk, R. L., Thorndike, J., Gaumont, Y., Ferone, R., Duch, D. S., Edelstein, M. P.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 962 KB

english, 1989

31

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224

Lau, Cheuk K., Belanger, Patrice C., Scheigetz, John, Dufresne, Claude, Williams, Haydn W. R., Maycock, Alan L., Guindon, Yvan, Bach, Thomas, Dallob, Aimee L.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 962 KB

english, 1989

32

Novel cytotoxic compounds from the ascidian Lissoclinum bistratum

Degnan, Bernard M., Hawkins, Clifford J., Lavin, Martin F., McCaffrey, Elizabeth J., Parry, David L., Watters, Diane J.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 679 KB

english, 1989

33

Synthesis and antimicrobial properties of substituted .beta.-aminoxypropionyl penicillins and cephalosporins

Balsamo, A., Broccali, G., Lapucci, A., Macchia, B., Macchia, F., Orlandini, E., Rossello, A.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 502 KB

english, 1989

34

Synthesis and binding affinities of cyclic and related linear analogs of CCK8 selective for central receptors

Charpentier, Bruno, Dor, Adeline, Roy, Pierre, England, Patrick, Pham Hung,, Durieux, Christiane, Roques, Bernard P.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1989

35

Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'-(dihydroxyphosphinyl)-.beta.-D-ribofuranosyl analogs of AMP, GMP, IMP, and CMP

Raju, Natarajan, Smee, Donald F., Robins, Roland K., Vaghefi, Morteza M.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1989

36

Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for the .delta.-opioid receptors in vitro

Kim, Chong Ho, Rothman, Richard B., Jacobson, Arthur E., Mattson, Mariena V., Bykov, Victor, Streaty, Richard A., Klee, Werner A., George, Clifford, Long, Joseph B., Rice, Kenner C.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 945 KB

english, 1989

37

Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase

Woster, Patrick M., Black, Alison Y., Duff, Keith J., Coward, James K., Pegg, Anthony E.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1989

38

N-[(Arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene d4 antagonists of novel structure

Musser, John H., Kreft, Anthony F., Bender, Reinhold H. W., Kubrak, Dennis M., Carlson, Richard P., Chang, Joseph, Hand, James M.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1989

39

Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations

Messer, William S., Ellerbrock, Brenda R., Smith, Douglas A., Hoss, Wayne

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 4.14 MB

english, 1989

40

7-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist

Djuric, Stevan W., Collins, Paul W., Jones, Peter H., Shone, Robert L., Tsai, Bie Shung, Fretland, Donald J., Butchko, Gregory M., Villani-Price, Doreen, Keith, Robert H.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 358 KB

english, 1989

41

The role of position four in angiotensin II antagonism: a structure-activity study

Samanen, James, Cash, T., Narindray, D., Brandeis, E., Yellin, T., Regoli, D.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 631 KB

english, 1989

42

New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella

Degnan, Bernard M., Hawkins, Clifford J., Lavin, Martin F., McCaffrey, Elizabeth J., Parry, David L., Van den Brenk, Anna L., Watters, Diane J.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 701 KB

english, 1989

43

Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 2. Stereospecificity of the ether side chain

Lin, Ai Jeng, Lee, Margaret, Klayman, Daniel L.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.18 MB

english, 1989

44

Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue

Rosenberg, Saul H., Woods, Keith W., Kleinert, Hollis D., Stein, Herman, Nellans, Hugh N., Hoffman, Daniel J., Spanton, Stephen G., Pyter, Richard A., Cohen, Jerome

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.61 MB

english, 1989