Volume 30; Issue 2

Journal of Medicinal Chemistry

Volume 30; Issue 2

1

Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines

McNamara, Dennis J., Cook, P. Dan

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1987

2

Antitumor imidazotetrazines. 14. Synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones

Lunt, Edward, Newton, Christopher G., Smith, Christopher, Stevens, Graham P., Stevens, Malcolm F. G., Straw, Colin G., Walsh, Roger J. A., Warren, Peter J., Fizames, Christian

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1987

3

NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. 2. Direct observation, characterization, and reactivity studies of iminocyclophosphamide and related species

Boyd, Victoria L., Summers, Michael F., Ludeman, Susan Marie, Egan, William, Zon, Gerald, Regan, Judith B.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.27 MB

english, 1987

4

Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogs

Haviv, Fortuna, Ratajczyk, James D., DeNet, Robert W., Martin, Yvonne C., Dyer, Richard D., Carter, George W.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 2.07 MB

english, 1987

5

Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogs of phenylbutazone

Vennerstrom, Jonathan L., Holmes, Thomas J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 541 KB

english, 1987

6

Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of .gamma.-aminobutyric acid acting as selective GABA-A antagonists

Wermuth, Camille Georges, Bourguignon, Jean Jacques, Schlewer, Gilbert, Gies, Jean Pierre, Schoenfelder, Angele, Melikian, Anita, Bouchet, Marie Jeanne, Chantreux, Dominique, Molimard, Jean Charles

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.44 MB

english, 1987

7

Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogs of pyrimidine deoxyribonucleosides against retroviruses

Lin, Tai Shun, Chen, Ming S., McLaren, Colin, Gao, You Song, Ghazzouli, Ismail, Prusoff, William H.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 725 KB

english, 1987

8

The mechanism of activation of 4-hydroxycyclophosphamide

Borch, Richard F., Millard, Jo Ann

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 612 KB

english, 1987

9

Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating

Diana, Guy D., Oglesby, Richard C., Akullian, Vahan, Carabateas, Philip M., Cutcliffe, David, Mallamo, John P., Otto, Michael J., McKinlay, Mark A., Maliski, Edward G., Michalec, Stephen J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 761 KB

english, 1987

10

5-Amino-4-(diazoacetyl)-1-.beta.-D-ribofuranosylimidazole, a new antileukemic agent

Thomas, H. Jeanette, Avery, Lisa N., Brockman, R. Wallace, Montgomery, John A.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 518 KB

english, 1987

11

Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]butyramide (RS-82856)

Venuti, Michael C., Jones, Gordon H., Alvarez, Robert, Bruno, John J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 2.11 MB

english, 1987

12

Synthetic and enzyme inhibition studies of pepstatin analogs containing hydroxyethylene and ketomethylene dipeptide isosteres

Holladay, Mark W., Salituro, Francesco G., Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1987

13

Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogs of benactyzine

Flavin, Michael T., Lu, Matthias C., Thompson, Emmanual B., Bhargava, Hemendra N.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1987

14

Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters

Musser, John H., Kubrak, Dennis M., Chang, Joseph, DiZio, Stephen M., Hite, Mark, Hand, James M., Lewis, Alan J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 696 KB

english, 1987

15

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogs of cilostamide and anagrelide

Jones, Gordon H., Venuti, Michael C., Alvarez, Robert, Bruno, John J., Berks, Andrew H., Prince, Anthony

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.34 MB

english, 1987

16

Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogs of statine

Salituro, Francesco G., Agarwal, Nirankar, Hofmann, Theo, Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.34 MB

english, 1987

17

Molecular modification of anticholinergics as probes for muscarinic receptors. 1. Amino esters of .alpha.-substituted phenylacetic acid and related analogs

Lu, Matthias C., Wung, Walley E., Shih, Lisa B., Callejas, Soledad, Gearien, James E., Thompson, Emmanuel B.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 880 KB

english, 1987

18

Book Reviews

Kier, Lemont, Hall, Lowell

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 384 KB

english, 1987

19

Stereochemical studies on the cytochrome P-450 catalyzed oxidation of (S)-nicotine to the (S)-nicotine .DELTA.1'(5')-iminium species

Peterson, Lisa A., Trevor, Anthony, Castagnoli, Neal

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 844 KB

english, 1987

20

Structure-activity relationships of sparsomycin and its analogs. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth

Van den Broek, Leon A. G. M., Liskamp, Rob M. J., Colstee, J. Hans, Lelieveld, Peter, Remacha, Miguel, Vazquez, David, Ballesta, Juan P. G., Ottenheijm, Harry C. J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1987

21

5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies

Al-Razzak, Laman A., Schwepler, Douglas, Decedue, Charles J., Balzarini, Jan, De Clercq, Erik, Mertes, Mathias P.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.55 MB

english, 1987

22

Bimorphinans as highly selective, potent .kappa. opioid receptor antagonists

Portoghese, P. S., Lipkowski, A. W., Takemori, A. E.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 261 KB

english, 1987

23

Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolism

Kwon, Chul Hoon, Borch, Richard F., Engel, Jurgen, Niemeyer, Ulf

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 588 KB

english, 1987

24

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 155 KB

english, 1987

25

Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli

Allen, Norris E., Alborn, William E., Kirst, Herbert A., Toth, John E.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1987

26

1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants

Bonnaud, Bernard, Cousse, Henri, Mouzin, Gilbert, Briley, Mike, Stenger, Antoine, Fauran, Francois, Couzinier, Jean Pierre

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1005 KB

english, 1987

27

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

Roth, Barbara, Rauckman, Barbara S., Ferone, Robert, Baccanari, David P., Champness, John N., Hyde, Richard M.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 2.27 MB

english, 1987

28

In search of the digitalis replacement

Erhardt, Paul W.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 812 KB

english, 1987

29

Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents

Jirkovsky, Ivo, Santroch, George, Baudy, Reinhardt, Oshiro, George

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1022 KB

english, 1987

30

1-[[[5-(Substituted phenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinediones, a new class of skeletal muscle relaxants

White, R. L., Wessels, F. L., Schwan, T. J., Ellis, K. O.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 513 KB

english, 1987

31

The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles

Biagi, Gian Luigi, Cantelli-Forti, Giorgio, Barbaro, Anna Maria, Guerra, Maria Clelia, Hrelia, Patrizia, Borea, Pier Andrea

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 421 KB

english, 1987

32

Synthetic bovine prothrombin precursor 13-29 for studies of vitamin K dependent carboxylase

Pottorf, Richard S., Rich, Daniel H., Engelke, Jean, Suttie, John W.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 598 KB

english, 1987

33

Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide]analogs

Haces, Alberto, Breitman, Theodore R., Driscoll, John S.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 751 KB

english, 1987

34

Synthesis and evaluation of mono-, di-, and trifluoroethenyl-GABA derivatives as GABA-T inhibitors

Kolb, Michael, Barth, Jacqueline, Heydt, Jean Georges, Jung, Michel J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 832 KB

english, 1987

35

Molecular modification of anticholinergics as probes for muscarinic receptors. 2. Amino esters of .alpha.-methyltropic acid

Lu, Matthias C., Shih, Lisa B., Jae, Hwan S., Gearien, James E., Thompson, Emmanual B.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 614 KB

english, 1987

36

Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogs of neplanocin A

Phadtare, Shashikant, Zemlicka, Jiri

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 599 KB

english, 1987