Volume 27; Issue 12

Journal of Medicinal Chemistry

Volume 27; Issue 12

1

Synthesis and activity of novel nitropyrazines for use as hypoxic cell radiosensitizers

Woodcock, Michael, Hartman, George D., Hartman, Richard D., Schwering, John E., Jones, Nigel R., Wardman, Peter, Watts, Margaret E.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 743 KB

english, 1984

2

Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents

Abou-Gharbia, Magid, Freed, Meier E., McCaully, Ronald J., Silver, Paul J., Wendt, Robert L.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 507 KB

english, 1984

3

Mesoionic pyridazine ribonucleosides. A novel biologically active nucleoside metabolite

Feeley, Daniel T., Lawton, Gerald C., Weaver, John M., Wemple, James, Bambury, Ronald E.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.41 MB

english, 1984

4

Novel pyrimidine and 1,3,5-triazine hypolipemic agents

D'Atri, Gaetano, Gomarasca, Piero, Resnati, Giuseppe, Tronconi, Giovanni, Scolastico, Carlo, Sirtori, Cesare R.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1984

5

Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones

Schmidhammer, Helmut, Aeppli, Lislott, Atwell, Louise, Fritsch, Florian, Jacobson, Arthur E., Nebuchla, Michaela, Sperk, Guenther

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 709 KB

english, 1984

6

Functional group contributions to drug-receptor interactions

Andrews, P. R., Craik, D. J., Martin, J. L.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.98 MB

english, 1984

7

Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists

Jones, James H., Anderson, Paul S., Baldwin, John J., Clineschmidt, Bradley V., McClure, David E., Lundell, George F., Randall, William C., Martin, Gregory E., Williams, Michael

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 798 KB

english, 1984

8

[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 1. Effects of nitrogen and aromatic nuclear substitution

Lee, Cheuk Man, Plattner, Jacob J., Ours, C. Wayne, Horrom, Bruce W., Smital, Jill R., Martin, Yvonne C., Pernet, Andre G., Bunnell, Paul R., El Masry, Souheir E., Dodge, Patrick W.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1984

9

Synthesis of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1,2,4-triazol-3-yl)thio]acetic acids as possible superoxide scavengers and antiinflammatory agents

Maxwell, James R., Wasdahl, Dan A., Wolfson, Alan C., Stenberg, Virgil I.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 705 KB

english, 1984

10

Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxymorphinones

Ko, Ronald P., Gupte, Sanjeev M., Nelson, Wendel L.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 434 KB

english, 1984

11

Peptide sweeteners. 6. Structural studies on the C-terminal amino acid of L-aspartyl dipeptide sweeteners

Tsang, Joseph W., Schmied, Bernhard, Nyfeler, Rolf, Goodman, Murray

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 852 KB

english, 1984

12

A potent multisubstrate analog inhibitor of human thymidylate synthetase

Srinivansan, Ananthachari, Amarnath, Venkataraman, Broom, Arthur D., Fou, F. C., Cheng, Yung Chi

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1984

13

A novel method of conjugation of daunomycin with antibody with a poly(L-glutamic acid) derivative as intermediate drug carrier. An anti-.alpha.-fetoprotein antibody-daunomycin conjugate

Kato, Yoshinori, Umemoto, Naoji, Kayama, Yasutaka, Fukushima, Hisashi, Takeda, Yumiko, Hara, Takeshi, Tsukada, Yutaka

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 812 KB

english, 1984

14

Synthesis and antitumor activity of tropolone derivatives. 1

Yamato, Masatoshi, Hashigaki, Kuniko, Kokubu, Nobuhiko, Tsuruo, Takashi, Tashiro, Tazuko

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 536 KB

english, 1984

15

Diastereomeric 6-desoxy-6-spiro-.alpha.-methylene-.gamma.-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand

Koolpe, Gary A., Nelson, Wendel L., Gioannini, T. L., Angel, Lloyd, Simon, Eric J.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 966 KB

english, 1984

16

Cyclopentenyluridine and cyclopentenylcytidine analogs as inhibitors of uridine-cytidine kinase

Lim, Mu Ill, Moyer, James D., Cysyk, Richard L., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 434 KB

english, 1984

17

Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity

Stuetz, Anton, Petranyi, Gabor

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 655 KB

english, 1984

18

Pyridonecarboxylic acids as antibacterial agents. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and its analogs

Egawa, Hiroshi, Miyamoto, Teruyuki, Minamida, Akira, Nishimura, Yoshiro, Okada, Hidetsugu, Uno, Hitoshi, Matsumoto, Junichi

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 727 KB

english, 1984

19

Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity

Sorenson, John R. J.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 426 KB

english, 1984

20

Bulky amine analogs of ketoprofen: potent antiinflammatory agents

Schlegel, Donald C., Zenitz, Bernard L., Fellows, Constance A., Laskowski, Stanley C., Behn, D. Craig, Phillips, Donald K., Botton, Irving, Speight, Phyllis T.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 940 KB

english, 1984

21

Additions and Corrections-2-Substituted Thiazolidine-4(R)-carboxylic Acids as Prodrugs of L-Cysteine. Protection of Mice Against Acetaminophen Hepatotoxicity

Nagasawa, Herbert, Goon, David, Muldoon, William, Zera, Richard

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 148 KB

english, 1984

22

Additions and Corrections-Antiextrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzo[b]thiophene Derivatives Leading to [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with Only Minimal Intrinsic Estrogenicity

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 149 KB

english, 1984

23

Effects of volume and surface property in hydrolysis by acetylcholinesterase. The trimethyl site

Cohen, Saul G., Elkind, Jerome L., Chishti, S. Bano, Giner, Jose L., Reese, Heide

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 758 KB

english, 1984

24

Pyrido[3',2':4,5]thieno[3,2-d]-N-triazines: a new series of orally active antiallergic agents

Youssefyeh, Raymond D., Brown, Richard E., Wilson, Jeffrey, Shah, Uresh, Jones, Howard, Loev, Bernard, Khandwala, Atul, Leibowitz, Mitchell J., Sonnino-Goldman, Paula

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 626 KB

english, 1984

25

Additions and Corrections-Development of an Affinity Ligand for Purification of Adrenoceptors from Human Platelet Membranes

DeMarinis, R, Krog, A, Shah, D, Lafferty, J, Holden, K, Hieble, J, Matthews, W, Regan, J, Lefkowitz, R, Caron, M

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 148 KB

english, 1984

26

Additions and Corrections- Chloroalanyl and Propargylglycyl Dipeptides. Suicide Substrate Containing Antibacterials

Cheung, Kam-Sing, Wasserman, Steven, Dudek, Edward, Lerner, A, Johnston, Michael

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 148 KB

english, 1984

27

[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 2. Modifications of the oxyacetic side chain

Plattner, Jacob J., Fung, Anthony K. L., Smital, Jill R., Lee, Cheuk Man, Crowley, Steven R., Pernet, Andre G., Bunnell, Paul R., Buckner, Steven A., Sennello, Lawrence T.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.32 MB

english, 1984

28

Peptide sweeteners. 7. Taste relationships of trifluoroacetyl-L-aspartylanilides

Rodriguez, Marc, Goodman, Murray

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 741 KB

english, 1984

29

Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in mouse cells in culture

Chawla, Ram R., Freed, Jerome J., Hampton, Alexander

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 574 KB

english, 1984

30

Synthesis and binding to tubulin of colchicine spin probes

Sharma, Padam N., Brossi, Arnold, Silverton, J. V., Chignell, Colin F.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 673 KB

english, 1984

31

Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property

Martinez, Jean, Magous, Richard, Lignon, Marie Francoise, Laur, Jeanine, Castro, Bertrand, Bali, Jean Pierre

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 764 KB

english, 1984

32

Masthead

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 134 KB

english, 1984

33

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzoxathian: a new antagonist with high potency and selectivity towards .alpha.1-adrenoreceptors

Melchiorre, Carlo, Brasili, Livio, Giardina, Dario, Pigini, Maria, Strappaghetti, Giovannella

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 263 KB

english, 1984

34

A substituent constant analysis of the interaction of substituted naphthalene monoimides with DNA

Stevenson, Karen A., Yen, Shau Fong, Yang, Nai Chuang, Boykin, David W., Wilson, W. David

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 826 KB

english, 1984

35

Additions and Corrections-Improved Synthesis and Antitumor Evaluation of 5,8-Dideazaisofolic Acid and Closely Related Analogues

Hynes, J, Yang, Y, McGill, J, Harmon, S, Washtien, W

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 148 KB

english, 1984

36

Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine)

Schneller, Stewart W., Luo, Jiann Kuan, Hosmane, Ramachandra S., De Clercq, Erik, Stoeckler, Johanna D., Agarwal, Kailash C., Parks, Robert E., Saunders, Priscilla P.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 443 KB

english, 1984

37

1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogs of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC)

Farquhar, David, Benvenuto, John

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 709 KB

english, 1984

38

A proton NMR study of the interactions and conformations of rationally designed brodimoprim analogs in complexes with Lactobacillus casei dihydrofolate reductase

Birdsall, B., Feeney, J., Pascual, C., Roberts, G. C. K., Kompis, I., Then, R. L., Mueller, K., Kroehn, A.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 714 KB

english, 1984

39

Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site

Abraham, Donald J., Gazze, David M., Kennedy, Paul E., Mokotoff, Michael

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.58 MB

english, 1984

40

3-Substituent effect and 3-methylene substituent effect on the structure-reactivity relationship of 7.beta.-(acylamino)-3-cephem-4-carboxylic acid derivatives studied by carbon-13 and IR spectroscopy

Nishikawa, Junko, Tori, K.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 829 KB

english, 1984

41

C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor

Nichols, David E., Jacob, James N., Hoffman, Andrew J., Kohli, Jai D., Glock, Dana

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 706 KB

english, 1984

42

Acidic furo[3,2-b]indoles. A new series of potent antiallergy agents

Unangst, Paul C., Carethers, Mary E., Webster, Kenneth, Janik, Grace M., Robichaud, Lillian J.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 684 KB

english, 1984

43

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

Anderson, Wayne K., Jones, Allen N.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1984

44

Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for .mu. or .delta. opiate receptors

Burke, Terrence R., Bajwa, Balbir S., Jacobson, Arthur E., Rice, Kenner C., Streaty, R. A., Klee, W. A.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 700 KB

english, 1984

45

Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides

Elslager, Edward F., Colbry, Norman L., Davoll, John, Hutt, Marland P., Johnson, Judith L., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 492 KB

english, 1984

46

Azasteroids as inhibitors of rat prostatic 5.alpha.-reductase

Rasmusson, Gary H., Reynolds, Glenn F., Utne, Torleif, Jobson, Ronald B., Primka, Raymond L., Berman, Charles, Brooks, Jerry R.

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1984

47

Book Reviews

Journal:

Journal of Medicinal Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 964 KB

english, 1984