Volume 35; Issue 2

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Investigational New Drugs
Volume 35; Issue 2

Investigational New Drugs

Volume 35; Issue 2

1

Alofanib, an allosteric FGFR2 inhibitor, has potent effects on ovarian cancer growth in preclinical studies

Tyulyandina, Alexandra, Harrison, Daniel, Yin, Wei, Stepanova, Evgenia, Kochenkov, Dmitry, Solomko, Eliso, Peretolchina, Nina, Daeyaert, Frits, Joos, Jean-Baptiste, Van Aken, Koen, Byakhov, Mikhail, G

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 3.82 MB

english, 2017

2

Safety of raltegravir-based antiretroviral therapy in HIV-infected patients receiving multi-kinase inhibitors

Loulergue, Pierre, Merad, Mansouria, Coriat, Romain, Ducreux, Michel, Planchard, David, Boige, Valérie, Le Cesne, Axel, Gregory, Thomas M., Poinsignon, Vianney, Paci, Angelo, Mir, Olivier

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 239 KB

english, 2017

3

Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors

Paz-Ares, Luis, Forster, Martin, Boni, Valentina, Szyldergemajn, Sergio, Corral, Jesús, Turnbull, Samantha, Cubillo, Antonio, Teruel, Carlos Fernandez, Calderero, Iker López, Siguero, Mariano, Bohan,

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 329 KB

english, 2017

4

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

Beg, Muhammad S., Brenner, Andrew J., Sachdev, Jasgit, Borad, Mitesh, Kang, Yoon-Koo, Stoudemire, Jay, Smith, Susan, Bader, Andreas G., Kim, Sinil, Hong, David S.

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 532 KB

english, 2017

5

Phase I study of Nivolumab, an anti-PD-1 antibody, in patients with malignant solid tumors

Yamamoto, Noboru, Nokihara, Hiroshi, Yamada, Yasuhide, Shibata, Takashi, Tamura, Yosuke, Seki, Yoshitaka, Honda, Kazunori, Tanabe, Yuko, Wakui, Hiroshi, Tamura, Tomohide

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 500 KB

english, 2017

6

Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

Lundberg, Alycen P., Francis, Joshua M., Pajak, Malgorzata, Parkinson, Elizabeth I., Wycislo, Kathryn L., Rosol, Thomas J., Brown, Megan E., London, Cheryl A., Dirikolu, Levent, Hergenrother, Paul J.,

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2017

7

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth

Shelake, Sagar, Sankpal, Umesh T., Paul Bowman, W., Wise, Matthew, Ray, Anish, Basha, Riyaz

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 1005 KB

english, 2017

8

Zebrafish phenotypic screen identifies novel Notch antagonists

Velaithan, Vithya, Okuda, Kazuhide Shaun, Ng, Mei Fong, Samat, Norazwana, Leong, Sze Wei, Faudzi, Siti Munirah Mohd, Abas, Faridah, Shaari, Khozirah, Cheong, Sok Ching, Tan, Pei Jean, Patel, Vyomesh

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 5.44 MB

english, 2017

9

Sunitinib-paracetamol sex-divergent pharmacokinetics and tissue distribution drug-drug interaction in mice

Liew, Ming Hui, Ng, Salby, Chew, Chii Chii, Koo, Teng Wai, Chee, Yun Lee, Chee, Evelyn Li-Ching, Modamio, Pilar, Fernández, Cecilia, Mariño, Eduardo L., Segarra, Ignacio

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2017

10

Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy

Tambo, Yuichi, Hosomi, Yukio, Sakai, Hiroshi, Nogami, Naoyuki, Atagi, Shinji, Sasaki, Yasutsuna, Kato, Terufumi, Takahashi, Toshiaki, Seto, Takashi, Maemondo, Makoto, Nokihara, Hiroshi, Koyama, Ryo, N

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 707 KB

english, 2017

11

A phase II study of carboplatin plus weekly paclitaxel with bevacizumab for elderly patients with non-squamous non-small-cell lung cancer (NEJ016)

Miura, Satoru, Maemondo, Makoto, Iwashima, Akira, Harada, Toshiyuki, Sugawara, Shunichi, Kobayashi, Kunihiko, Inoue, Akira, Nakagawa, Taku, Takiguchi, Yuichi, Watanabe, Hiroshi, Ishida, Takashi, Terad

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 647 KB

english, 2017

12

Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C

Almhanna, Khaldoun, Miron, Maria Luisa Limon, Wright, David, Gracian, Antonio Cubillo, Hubner, Richard A., Van Laethem, Jean-Luc, López, Carolina Muriel, Alsina, Maria, Muñoz, Frederico Longo, Bendell

Journal:

Investigational New Drugs

Année:

2017

Fichier:

PDF, 5 KB

2017

13

A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone

Cleary, James M., Rosen, Lee S., Yoshida, Kenichiro, Rasco, Drew, Shapiro, Geoffrey I., Sun, Weijing

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 466 KB

english, 2017

14

Erratum to: Zebrafish phenotypic screen identifies novel Notch antagonists

Vithya Velaithan,Kazuhide Shaun Okuda,Mei Fong Ng…

Journal:

Investigational New Drugs

Année:

2017

Langue:

english

Fichier:

PDF, 185 KB

english, 2017