Volume 34; Issue 5

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Investigational New Drugs
Volume 34; Issue 5

Investigational New Drugs

Volume 34; Issue 5

1

The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line

Pezzani, Raffaele, Rubin, Beatrice, Bertazza, Loris, Redaelli, Marco, Barollo, Susi, Monticelli, Halenya, Baldini, Enke, Mian, Caterina, Mucignat, Carla, Scaroni, Carla, Mantero, Franco, Ulisse, Salva

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2016

2

In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118

Salustiano, Eduardo J., Dumas, Matheus L., Silva-Santos, Gabriel G., Netto, Chaquip D., Costa, Paulo R. R., Rumjanek, Vivian M.

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2016

3

Prediction of response to everolimus in neuroendocrine tumors: evaluation of clinical, biological and histological factors

Benslama, Noura, Bollard, Julien, Vercherat, Cécile, Massoma, Patrick, Roche, Colette, Hervieu, Valérie, Peron, Julien, Lombard-Bohas, Catherine, Scoazec, Jean-Yves, Walter, Thomas

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 846 KB

english, 2016

4

Intravenous and intraperitoneal paclitaxel with S-1 for treatment of refractory pancreatic cancer with malignant ascites

Takahara, Naminatsu, Isayama, Hiroyuki, Nakai, Yousuke, Ishigami, Hironori, Satoi, Sohei, Mizuno, Suguru, Kogure, Hirofumi, Matsubara, Saburo, Yamamoto, Natsuyo, Yamaguchi, Hironori, Tada, Minoru, Kit

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 401 KB

english, 2016

5

Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine–induced apoptosis in neuroblastoma cells

Lennon, Jennifer C., Butini, Stefania, Campiani, Giuseppe, O’Meara, Anne, Williams, D. Clive, Zisterer, Daniela M.

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 871 KB

english, 2016

6

Phase II evaluation of LY2603618, a first-generation CHK1 inhibitor, in combination with pemetrexed in patients with advanced or metastatic non-small cell lung cancer

Scagliotti, Giorgio, Kang, Jin Hyoung, Smith, David, Rosenberg, Richard, Park, Keunchil, Kim, Sang-We, Su, Wu-Chou, Boyd, Thomas E., Richards, Donald A., Novello, Silvia, Hynes, Scott M., Myrand, Scot

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 771 KB

english, 2016

7

Phase I dose-finding study of monotherapy with atezolizumab, an engineered immunoglobulin monoclonal antibody targeting PD-L1, in Japanese patients with advanced solid tumors

Mizugaki, Hidenori, Yamamoto, Noboru, Murakami, Haruyasu, Kenmotsu, Hirotsugu, Fujiwara, Yutaka, Ishida, Yoshimasa, Kawakami, Tomohisa, Takahashi, Toshiaki

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 398 KB

english, 2016

8

AphaseItrial of the aurora kinase inhibitor, ENMD-2076,in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia

Yee, Karen W. L., Chen, Hsiao-Wei T., Hedley, David W., Chow, Sue, Brandwein, Joseph, Schuh, Andre C., Schimmer, Aaron D., Gupta, Vikas, Sanfelice, Deborah, Johnson, Tara, Le, Lisa W., Arnott, Jamie,

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 552 KB

english, 2016

9

A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors

Rosen, Lee S., LoRusso, Patricia, Ma, Wen Wee, Goldman, Jonathan W., Weise, Amy, Colevas, A. Dimitrios, Adjei, Alex, Yazji, Salim, Shen, Angela, Johnston, Stuart, Hsieh, Hsin-Ju, Chan, Iris T., Sikic,

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2016

10

A phase I dose-escalation study of LY2875358, a bivalent MET antibody, given as monotherapy or in combination with erlotinib or gefitinib in Japanese patients with advanced malignancies

Yoh, Kiyotaka, Doi, Toshihiko, Ohmatsu, Hironobu, Kojima, Takashi, Takahashi, Hideaki, Zenke, Yoshitaka, Wacheck, Volker, Enatsu, Sotaro, Nakamura, Takashi, Turner, Kellie, Uenaka, Kazunori

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 952 KB

english, 2016

11

Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report

Kusaczuk, Magdalena, Krętowski, Rafał, Stypułkowska, Anna, Cechowska-Pasko, Marzanna

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 5.50 MB

english, 2016

12

Intravitreal vascular endothelial growth factor (VEGF) inhibitor injection in unrecognised early pregnancy

Kianersi, Farzan, Ghanbari, Heshmatollah, Naderi Beni, Zahra, Naderi Beni, Afsaneh

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 249 KB

english, 2016

13

The renal effects of ALK inhibitors

Izzedine, Hassan, El-Fekih, Rania Kheder, Perazella, Mark A.

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 306 KB

english, 2016

14

Pharmacokinetics and excretion of14C-omacetaxine in patients with advanced solid tumors

Nijenhuis, Cynthia M., Hellriegel, Edward, Beijnen, Jos H., Hershock, Diane, Huitema, Alwin D. R., Lucas, Luc, Mergui-Roelvink, Marja, Munteanu, Mihaela, Rabinovich-Guilatt, Laura, Robertson, Philmore

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 729 KB

english, 2016

15

Phase I trial of dacomitinib, a pan-human epidermal growth factor receptor (HER) inhibitor, with concurrent radiotherapy and cisplatin in patients with locoregionally advanced squamous cell carcinoma of the head and neck (XDC-001)

Prawira, Amy, Brana-Garcia, Irene, Spreafico, Anna, Hope, Andrew, Waldron, John, Razak, Albiruni R. Abdul, Chen, Eric X, Jang, Raymond, O’Sullivan, Brian, Giuliani, Meredith, Bayley, Andrew, Cho, John

Journal:

Investigational New Drugs

Année:

2016

Langue:

english

Fichier:

PDF, 415 KB

english, 2016