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Volume 33; Issue 1

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Investigational New Drugs
Volume 33; Issue 1

Investigational New Drugs

Volume 33; Issue 1

1

Phase 1 combination study of Eribulin mesylate with trastuzumab for advanced or recurrent human epidermal growth factor receptor 2 positive breast cancer

Mukai, Hirofumi, Saeki, Toshiaki, Shimada, Ken, Naito, Yoichi, Matsubara, Nobuaki, Nakanishi, Tadashi, Obaishi, Hiroshi, Namiki, Masayuki, Sasaki, Yasutsuna

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 285 KB

english, 2015

2

A phase I open-label study of the safety, tolerability, and pharmacokinetics of pazopanib in combination with irinotecan and cetuximab for relapsed or refractory metastatic colorectal cancer

Bennouna, Jaafar, Deslandres, Marion, Senellart, Helene, de Labareyre, Cecile, Ruiz-Soto, Rodrigo, Wixon, Claire, Botbyl, Jeff, Suttle, A. Benjamin, Delord, Jean-Pierre

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 227 KB

english, 2015

3

Preclinical combination therapy of the investigational drug NAMI-A+with doxorubicin for mammary cancer

Bergamo, Alberta, Riedel, Tina, Dyson, Paul J., Sava, Gianni

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2015

4

Momordica Charantialectin exhibits antitumor activity towards hepatocellular carcinoma

Zhang, Chris Zhiyi, Fang, Evandro Fei, Zhang, Hai-Tao, Liu, Li-Li, Yun, Jing-Ping

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 5.37 MB

english, 2015

5

4,5-Diaryl imidazoles with hydroxamic acid appendages as anti-hepatoma agents

Di Fazio, Pietro, Lingelbach, Susanne, Schobert, Rainer, Biersack, Bernhard

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 824 KB

english, 2015

6

The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells

Guzmán, Esther A., Maers, Kelly, Roberts, Jill, Kemami-Wangun, Hilaire V., Harmody, Dedra, Wright, Amy E.

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2015

7

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

Leijen, Suzanne, Burgers, Sjaak A., Baas, Paul, Pluim, Dick, Tibben, Matthijs, van Werkhoven, Erik, Alessio, Enzo, Sava, Gianni, Beijnen, Jos H., Schellens, Jan H. M.

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 382 KB

english, 2015

8

Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors

Puzanov, Igor, Sosman, Jeffrey, Santoro, Armando, Saif, Muhammad W., Goff, Laura, Dy, Grace K., Zucali, Paolo, Means-Powell, Julie A., Ma, Wen Wee, Simonelli, Matteo, Martell, Robert, Chai, Feng, Lama

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 439 KB

english, 2015

9

Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent

Ouchani, Farid, Jeanne, Albin, Thevenard, Jessica, Helesbeux, Jean-Jacques, Wahart, Amandine, Letinois, Isabelle, Duval, Olivier, Martiny, Laurent, Charpentier, Emmanuelle, Devy, Jérôme

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 8.83 MB

english, 2015

10

A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer

Bendell, Johanna C., Jones, Suzanne F., Hart, Lowell, Spigel, David R., Lane, Cassie M., Earwood, Chris, Infante, Jeffrey R., Barton, John, Burris, Howard A.

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 261 KB

english, 2015

11

BYL719, a selective inhibitor of phosphoinositide 3-Kinase α, enhances the effect of selumetinib (AZD6244, ARRY-142886) in KRAS-mutant non-small cell lung cancer

Ku, Bo Mi, Jho, Eun Hye, Bae, Yeon-Hee, Sun, Jong-Mu, Ahn, Jin Seok, Park, Keunchil, Ahn, Myung-Ju

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2015

12

Identification of cellular and molecular factors determining the response of cancer cells to six ergot alkaloids

Mrusek, Marco, Seo, Ean-Jeong, Greten, Henry Johannes, Simon, Michael, Efferth, Thomas

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 798 KB

english, 2015

13

A phase II trial of bevacizumab plus temsirolimus in patients with advanced hepatocellular carcinoma

Knox, Jennifer J., Qin, Rui, Strosberg, Jonathan R., Tan, Benjamin, Kaubisch, Andreas, El-Khoueiry, Anthony B., Bekaii-Saab, Tanios S., Rousey, Steven R., Chen, Helen X., Erlichman, Charles

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 211 KB

english, 2015

14

Successful treatment of Evans syndrome with Tacrolimus

Tabchi, Samer, Hanna, Colette, Kourie, Hampig Raphael, Aftimos, Philippe, El Osta, Lana, Ghosn, Marwan

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 245 KB

english, 2015

15

Novel benzoxazines as inhibitors of angiogenesis

Al-Rawi, Sara, Meehan-Andrews, Terri, Bradley, Chris, Al-Rawi, Jasim

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 379 KB

english, 2015

16

In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator

Ouellet, Charles, Ouellet, Étienne, Poirier, Donald

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 986 KB

english, 2015

17

Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells

Ali Azouaou, Sarah, Emhemmed, Fathi, Idris-Khodja, Noureddine, Lobstein, Annelise, Schini-Kerth, Valérie, Muller, Christian D., Fuhrmann, Guy

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2015

18

Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth inNod-Scid mice

Hazra, Sudipta, Ghosh, Subhalakshmi, Kumar, Amit, Pandey, B. N., Hazra, Banasri

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2015

19

Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients

Narjoz, C., Cessot, A., Thomas-Schoemann, A., Golmard, J. L., Huillard, O., Boudou-Rouquette, P., Behouche, A., Taieb, F., Durand, J. P., Dauphin, A., Coriat, R., Vidal, M., Tod, M., Alexandre, J., Lo

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 509 KB

english, 2015

20

Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors

Falchook, Gerald S., Wheler, Jennifer J., Naing, Aung, Piha-Paul, Sarina A., Fu, Siqing, Tsimberidou, Apostolia M., Hong, David S., Janku, Filip, Zinner, Ralph, Jiang, Yunfang, Huang, Mei, Lin, Quan,

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 652 KB

english, 2015

21

A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma

Goyal, Lipika, Wadlow, Raymond C., Blaszkowsky, Lawrence S., Wolpin, Brian M., Abrams, Thomas A., McCleary, Nadine Jackson, Sheehan, Susan, Sundaram, Eamala, Karol, Michael D., Chen, John, Zhu, Andrew

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 278 KB

english, 2015

22

Phase I dose-escalation study evaluating safety, tolerability and pharmacokinetics of MEDI-573, a dual IGF-I/II neutralizing antibody, in Japanese patients with advanced solid tumours

Iguchi, Haruo, Nishina, Tomohiro, Nogami, Naoyuki, Kozuki, Toshiyuki, Yamagiwa, Yumiko, Yagawa, Katsuro

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 278 KB

english, 2015

23

An innovative, multi-arm, complete phase 1b study of the novel anti-cancer agent tasisulam in patients with advanced solid tumors

Jotte, Robert M., Von Hoff, Daniel D., Braiteh, Fadi, Becerra, Carlos R., Richards, Donald A., Smith, David A., Garbo, Lawrence, Stephenson, Joe, Conkling, Paul R., Robert-Vizcarrondo, Francisco, Chen

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 372 KB

english, 2015

24

Pharmacokinetics and excretion of14C-lenvatinib in patients with advanced solid tumors or lymphomas

Dubbelman, Anne-Charlotte, Rosing, Hilde, Nijenhuis, Cynthia, Huitema, Alwin D. R., Mergui-Roelvink, Marja, Gupta, Anubha, Verbel, David, Thompson, Gary, Shumaker, Robert, Schellens, Jan H. M., Beijne

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 336 KB

english, 2015

25

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma

Schiff, David, Kesari, Santosh, de Groot, John, Mikkelsen, Tom, Drappatz, Jan, Coyle, Thomas, Fichtel, Lisa, Silver, Bruce, Walters, Ian, Reardon, David

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 526 KB

english, 2015

26

A phase I trial of combination trastuzumab, lapatinib, and bevacizumab in patients with advanced cancer

Falchook, Gerald S., Moulder, Stacy, Naing, Aung, Wheler, Jennifer J., Hong, David S., Piha-Paul, Sarina A., Tsimberidou, Apostolia M., Fu, Siqing, Zinner, Ralph, Janku, Filip, Jiang, Yunfang, Huang,

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 362 KB

english, 2015

27

Erratum to: Effect of simvastatin plus cetuximab/irinotecan forKRASmutant colorectal cancer and predictive value of theRASsignature for treatment response to cetuximab

Lee, Jeeyun, Hong, Yong Sang, Hong, Jung Yong, Han, Se Won, Kim, Tae Won, Kang, Hye Jin, Kim, Tae You, Kim, Kyu-pyo, Kim, Suk Hyung, Do, In-Gu, Kim, Kyoung-Mee, Sohn, Insuk, Park, Se Hoon, Park, Joon

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 503 KB

english, 2015

28

Duodenal ischemia and upper GI bleeding are dose-limiting toxicities of 24-h continuous intra-arterial pancreatic perfusion of gemcitabine following vascular isolation of the pancreatic head: early results from the Regional Chemotherapy in Locally Advanced Pancreatic Cancer (RECLAP) study

Beane, Joal D., Griffin, Kayla F., Levy, Elliot B., Pandalai, Prakash, Wood, Bradford, Abi-Jaoudeh, Nadine, Beresnev, Tatiana, Shutack, Yvonne, Webb, Carole C., Avital, Itzhak, Rudloff, Udo

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 4.78 MB

english, 2015

29

A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors

LoConte, Noelle K., Razak, Albiruni R. A., Ivy, Percy, Tevaarwerk, Amye, Leverence, Rachael, Kolesar, Jill, Siu, Lillian, Lubner, Sam J., Mulkerin, Daniel L., Schelman, William R., Deming, Dustin A.,

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 223 KB

english, 2015

30

A phase I study of the histone deacetylase (HDAC) inhibitor entinostat, in combination with sorafenib in patients with advanced solid tumors

Ngamphaiboon, Nuttapong, Dy, Grace K., Ma, Wen Wee, Zhao, Yujie, Reungwetwattana, Thanyanan, DePaolo, Dawn, Ding, Yi, Brady, William, Fetterly, Gerald, Adjei, Alex A.

Journal:

Investigational New Drugs

Année:

2015

Langue:

english

Fichier:

PDF, 466 KB

english, 2015