Volume 22; Issue 4

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Investigational New Drugs
Volume 22; Issue 4

Investigational New Drugs

Volume 22; Issue 4

1

Preliminary evaluationin vitroof the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene

Maurizio Viale, Maria A. Mariggiò, Massimo Ottone, Barbara Chiavarina, Angela Vinella, Claudia Prevosto, Carlo Dell'Erba, Giovanni Petrillo, Marino Novi

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 253 KB

english, 2004

2

Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma

Elisabeth Miot-Noirault, Jean Legault, Florent Cachin, Emmanuelle Mounetou, Françoise Degoul, René C. Gaudreault, Nicole Moins, Jean Claude Madelmont

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 122 KB

english, 2004

3

Growth inhibition, G1-arrest, and apoptosis in MCF-7 human breast cancer cells by novel highly lipophilic 5-fluorouracil derivatives

Juan Antonio Marchal, Houria Boulaiz, Inés Suárez, Estrella Saniger, Joaquín Campos, Esmeralda Carrillo, José Prados, Miguel Angel Gallo, Antonio Espinosa, Antonia Aránega

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 287 KB

english, 2004

4

Inhibitory effect of polypeptide fromChlamys farrerion UVA-induced apoptosis in human keratinocytes

Mei Dou, YanTao Han, ZhiWu Han, XiangGuo Chen, YueJun Wang, JinShan Tan, ChunBo Wang, YingYi Hou

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 260 KB

english, 2004

5

Antiproliferative effects of ZD0473 (AMD473) in combination with 5-Fluorouracil or SN38 in human colorectal cancer cell lines

Carmen Plasencia, Albert Abad, Eva Martinez-Balibrea, Miquel Taron

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 132 KB

english, 2004

6

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1)in vivo

Joachim Gullbo, Elin Lindhagen, Saadia Bashir-Hassan, Marcus Tullberg, Hans Ehrsson, Rolf Lewensohn, Peter Nygren, Manuel de la Torre, Kristina Luthman, Rolf Larsson

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 251 KB

english, 2004

7

Phase I trial of continuous infusion recombinant human interleukin-4 in patients with cancer

Navneet S. Majhail, Mohamad Hussein, Thomas E. Olencki, George T. Budd, Laura Wood, Paul Elson, Ronald M. Bukowski

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 60 KB

english, 2004

8

Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs

Susan M. Chang, John Kuhn, Patrick Wen, Harry Greenberg, David Schiff, Charles Conrad, Karen Fink, H. Ian Robins, Timothy Cloughesy, Lisa De Angelis, Jeffrey Razier, Kenneth Hess, Janet Dancey, Michae

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 115 KB

english, 2004

9

A phase I and pharmacokinetic study of the nonpolyglutamatable thymidylate synthase inhibitor ZD9331 plus docetaxel in patients with advanced solid malignancies

Garry H. Schwartz, Christopher B. Jones, Mitchell Garrison, Amita Patnaik, Chris Takimoto, Heather McCreery, Michael Skinner, Anthony W. Tolcher, Eric K. Rowinsky

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 145 KB

english, 2004

10

Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors

Samir D. Undevia, Nicholas J. Vogelzang, Ann M. Mauer, Linda Janisch, Sridhar Mani, Mark J. Ratain

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 147 KB

english, 2004

11

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

Henry Q. Xiong, Roy Herbst, Silvana C. Faria, Catherine Scholz, Darren Davis, Edward F. Jackson, Timothy Madden, David McConkey, Marshall Hicks, Kenneth Hess, Chusilp (Arthur) Charnsangavej, James L.

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 82 KB

english, 2004

12

A phase II pilot study of high-dose 24-hour continuous infusion of 5-FU and leucovorin and low-dose PALA for patients with colorectal cancer: A Southwest Oncology Group study

Robert P. Whitehead, Jacqueline K. Benedetti, James L. Abbruzzese, Bach Ardalan, Stephen Williamson, Ellen R. Gaynor, Stanley P. Balcerzak, John S. Macdonald

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 70 KB

english, 2004

13

Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma

Devansu Tewari, Bradley J. Monk, Mark Hunter, Camille A. Falkner, Robert A. Burger

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 110 KB

english, 2004

14

Docetaxel plus fractionated cisplatin is a safe and active schedule as first-line treatment of patients with advanced non-small cell lung cancer: Results of a phase II study

José Luis Firvida, Margarita Amenedo, Rubén Rodríguez, Ana González, Mercedes Salgado, Manuel Ramos, Gustavo Losada

Journal:

Investigational New Drugs

Année:

2004

Langue:

english

Fichier:

PDF, 110 KB

english, 2004