Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria.
Mayoka, Godfrey, Njoroge, Mathew, Okombo, John, Gibhard, Liezl, Sanches-Vaz, Margarida, Fontinha, Diana, Birkholtz, Lyn-Marie, Reader, Janette, van der Watt, Mariëtte, Coetzer, Theresa L., Lauterbach,Langue:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.8b01769
Date:
December, 2018
Fichier:
PDF, 1.73 MB
english, 2018