Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond to Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain
Fuchino, Kouki, Mitsuoka, Yasunori, Masui, Moriyasu, Kurose, Noriyuki, Yoshida, Shuhei, Komano, Kazuo, Yamamoto, Takahiko, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanoro, Sakaguchi, GaLangue:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.8b00002
Date:
May, 2018
Fichier:
PDF, 1016 KB
english, 2018
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