Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: Identification of development candidate (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael R., Deng, Ya-Li, Dinh, Dac M, Fan, Connie, Gajiwala, Ketan S, Grantner, Rita, Gukasyan, Hovhannes J., Hu, Wenyue, Huang, Buwen, Kania,Langue:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.7b01375
Date:
December, 2017
Fichier:
PDF, 1.72 MB
english, 2017
File converter
Plus de résultats de recherche
More benefits 
