The Rational Design of Selective Benzoxazepin Inhibitors of the -Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Heffron, Timothy P, Heald, Robert Andrew, Ndubaku, Chudi O, Wei, BinQing, Augustin, Martin, Do, Steven, Edgar, Kyle, Eigenbrot, Charlie, Lori, Friedman, Gancia, Emanuela, Jackson, Philip, Jones, GrahaLangue:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.5b01483
Date:
January, 2016
Fichier:
PDF, 1.37 MB
english, 2016
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