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1

Summary of Breakout Session B: Regulatory Expectations for CGMP

Sausville, R., Cazeault, C.

Journal:

PDA Journal of Pharmaceutical Science and Technology

Année:

2011

Langue:

english

Fichier:

PDF, 404 KB

english, 2011

2

Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

Brian K. Adams, Eva M. Ferstl, Matthew C. Davis, Marike Herold, Serdar Kurtkaya, Richard F. Camalier, Melinda G. Hollingshead, Gurmeet Kaur, Edward A. Sausville, Frederick R. Rickles, James P. Snyder,

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 508 KB

english, 2004

3

Jasplakinolide's Inhibition of the Growth of Prostate Carcinoma Cells In Vitro With Disruption of the Actin Cytoskeleton

Senderowicz, A. M. J., Kaur, G., Sainz, E., Laing, C., Inman, W. D., Rodriguez, J., Crews, P., Malspeis, L., Grever, M. R., Sausville, E. A., Duncan, K. L. K.

Journal:

JNCI Journal of the National Cancer Institute

Année:

1995

Langue:

english

Fichier:

PDF, 1.78 MB

english, 1995

4

S IGNAL T RANSDUCTION –D IRECTED C ANCER T REATMENTS *

Sausville, Edward A., Elsayed, Yusri, Monga, Manish, Kim, George

Journal:

Annual Review of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 471 KB

english, 2003

5

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

Sausville, Edward, Tomaszewski, Joseph, Ivy, Percy

Journal:

Current Cancer Drug Targets

Année:

2003

Langue:

english

Fichier:

PDF, 91 KB

english, 2003

6

Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy

Newman, David, Cragg, Gordon, Holbeck, Susan, Sausville, Edward

Journal:

Current Cancer Drug Targets

Année:

2002

Langue:

english

Fichier:

PDF, 260 KB

english, 2002

7

Prolactin-producing pituitary carcinoma with pulmonary metastases

Daniel M. Atienza, Robert J. Vigersky, Ernest E. Lack, Marisa Carriaga, Eileen J. Rusnock, Edward Tsou, Federico Cerrone, Jorge G. Kattah, Edward A. Sausville

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 861 KB

english, 1991

8

Prognostic implications of a bone marrow histopathologic classification system in mycosis fungoides and the Sézary syndrome

Scott J. Graham, Robert W. Sharpe, Seth M. Steinberg, James D. Cotelingam, Edward A. Sausville, Francine M. Foss

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 863 KB

english, 1993

9

Lymphomatoid papulosis associated with Ki-1-positive anaplastic large cell lymphoma. A report of two cases and a review of the literature

Matthew J. McCarty, Svetislava J. Vukelja, Edward A. Sausville, James J. Perry, William D. James, Elaine S. Jaffe, Raymond B. Weiss

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 3.05 MB

english, 1994

10

Antitumor activity of suramin in hormone-refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variables

Nancy A. Dawson, Michael R. Cooper, William D. Figg, Donna J. Headlee, Alain Thibault, Raymond C. Bergan, Seth M. Steinberg, Edward A. Sausville, Charles E. Myers, Oliver Sartor

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 965 KB

english, 1995

11

A high-performance liquid chromatography method using ultraviolet and fluorescence detection for the quantitation of UCN-01, 7-hydroxystaurosporine, from human plasma and saliva

Kenneth S. Bauer, Richard M. Lush, Michelle A. Rudek, Carolyn Shih, Edward Sausville, William D. Figg

Journal:

Biomedical Chromatography

Année:

2000

Langue:

english

Fichier:

PDF, 70 KB

english, 2000

12

A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma

Suoping Zhai, Edward Sausville, William D. Figg

Journal:

Biomedical Chromatography

Année:

2002

Langue:

english

Fichier:

PDF, 70 KB

english, 2002

13

ChemInform Abstract: 2-Substituted Paullones: CDK1/Cyclin B-Inhibiting Property and in vitro Antiproliferative Activity.

Conrad Kunick, Christiane Schultz, Thomas Lemcke, Daniel W. Zaharevitz, Rick Gussio, Ravi K. Jalluri, Edward A. Sausville, Maryse Leost, Laurent Meijer

Journal:

Année:

2000

Fichier:

PDF, 28 KB

2000

14

ChemInform Abstract: Synthesis and Antitumor Activity of Some Aryl Semicarbazones.

S. N. Pandeya, P. Yogeeswari, E. A. Sausville, A. B. Mauger, V. L. Narayanan

Journal:

Année:

2001

Fichier:

PDF, 26 KB

2001

15

ChemInform Abstract: Synthesis and Antitumor Evaluation of 4-Bromophenyl Semicarbazones.

Surendra N. Pandeya, Perumal Yogeeswari, Edward A. Sausville, Anthony B. Mauger, Ven L. Narayanan

Journal:

Année:

2002

Fichier:

PDF, 27 KB

2002

16

Developmental Therapeutics Program at the NCI: Molecular Target and Drug Discovery Process

M. Monga, E. A. Sausville

Journal:

Année:

2003

Fichier:

PDF, 51 KB

2003

17

Cell microarray platform for anticancer drug development

Min-Jung Lee, Eun Joo Chung, Sunmin Lee, Joon-Yong Chung, William G. Telford, Edward A. Sausville, Ivana Gojo, Judith E. Karp, Steven D. Gore, Veena Kapoor, Yeong Sang Kim, Shivaani Kummar, Martin Gut

Journal:

Drug Development Research

Année:

2007

Langue:

english

Fichier:

PDF, 389 KB

english, 2007

18

A protein expression database for the molecular pharmacology of cancer

Dr. Timothy G. Myers, N. Leigh Anderson, Mark Waltham, Guang Li, John K. Buolamwini, Dominic A. Scudiero, Kenneth D. Paull, Edward A. Sausville, Dr. John N. Weinstein

Journal:

ELECTROPHORESIS

Année:

1997

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1997

19

Involvement of signal transduction pathways in lung cancer biology

Dr. Jean Viallet, Edward A. Sausville

Journal:

Journal of Cellular Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 912 KB

english, 1996

20

Bombesin receptor structure and expression in human lung carcinoma cell lines

Zahra Fathi, James W. Way, Martha H. Corjay, Jean Viallet, Edward A. Sausville, James F. Battey

Journal:

Journal of Cellular Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 1000 KB

english, 1996

21

Synthesis, structure–activity relationship, and p210bcr-abl protein tyrosine kinase activity of novel AG 957 analogs

Gurmeet Kaur, Ven L. Narayanan, Prabhakar A. Risbood, Melinda G. Hollingshead, Sherman F. Stinson, Ravi K. Varma, Edward A. Sausville

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 255 KB

english, 2005

22

Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation

Yuehai Shen, Qian Xie, Monica Norberg, Edward Sausville, George Vande Woude, David Wenkert

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 291 KB

english, 2005

23

Determination of MS-275, a novel histone deacetylase inhibitor, in human plasma by liquid chromatography–electrospray mass spectrometry

Kyunghwa Hwang, Milin R Acharya, Edward A Sausville, Suoping Zhai, Eunhee W Woo, Jürgen Venitz, William D Figg, Alex Sparreboom

Journal:

Journal of Chromatography B

Année:

2004

Langue:

english

Fichier:

PDF, 100 KB

english, 2004

24

Quantitative determination of perifosine, a novel alkylphosphocholine anticancer agent, in human plasma by reversed-phase liquid chromatography–electrospray mass spectrometry

Eunhee W Woo, Richard Messmann, Edward A Sausville, William D Figg

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

2001

Langue:

english

Fichier:

PDF, 149 KB

english, 2001

25

2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity

Conrad Kunick, Christiane Schultz, Thomas Lemcke, Daniel W Zaharevitz, Rick Gussio, Ravi K Jalluri, Edward A Sausville, Maryse Leost, Laurent Meijer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 125 KB

english, 2000

26

Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses

Hong-Bin Fang, Douglas D. Ross, Edward Sausville, Ming Tan

Journal:

Statistics in Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 183 KB

english, 2008

27

In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC

Ioannis A. Avramis, Garyfallia Christodoulopoulos, Atsushi Suzuki, Walter E. Laug, Ignacio Gonzalez-Gomez, George McNamara, Edward A. Sausville, Vassilios I. Avramis

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 1.76 MB

english, 2002

28

Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines

IoannisA. Avramis, WalterE. Laug, EdwardA. Sausville, VassiliosI. Avramis

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 347 KB

english, 2003

29

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

Victoria Smith, Edward A. Sausville, Richard F. Camalier, Heinz-Herbert Fiebig, Angelika M. Burger

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 507 KB

english, 2005

30

In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative

Melinda Hollingshead, Michael Alley, Angelika M. Burger, Suzanne Borgel, Christine Pacula-Cox, Heinz-Herbert Fiebig, Edward A. Sausville

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 434 KB

english, 2005

31

Interspecies differences in plasma protein binding of MS-275, a novel histone deacetylase inhibitor

Milin R. Acharya, Alex Sparreboom, Edward A. Sausville, Barbara A. Conley, James H. Doroshow, Jűrgen Venitz, William D. Figg

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 303 KB

english, 2006

32

Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells

Eileen Brantley, Smitha Antony, Glenda Kohlhagen, LingHua Meng, Keli Agama, Sherman F. Stinson, Edward A. Sausville, Yves Pommier

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 433 KB

english, 2006

33

A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas

Shivaani Kummar, Martin E. Gutierrez, Erin R. Gardner, William D. Figg, Giovanni Melillo, Janet Dancey, Edward A. Sausville, Barbara A. Conley, Anthony J. Murgo, James H. Doroshow

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 181 KB

english, 2010

34

Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma

Hideya Takeuchi, Gulshan Ara, Edward A. Sausville, Beverly Teicher

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 289 KB

english, 1998

35

Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts

Francisco Arguello, Mark A. Alexander, John F. Greene Jr., Sherman F. Stinson, Jean L. Jorden, Erik M. Smith, Naina T. Kalavar, W. Gregory Alvord, Richard L. Klabansky, Edward A. Sausville

Journal:

Journal of Cancer Research and Clinical Oncology

Année:

1998

Langue:

english

Fichier:

PDF, 401 KB

english, 1998

36

Factors affecting the pharmacokinetic profile of MS-275, a novel histone deacetylase inhibitor, in patients with cancer

Milin R. Acharya, Judith E. Karp, Edward A. Sausville, Kyunghwa Hwang, Qin Ryan, Ivana Gojo, Jűrgen Venitz, William D. Figg, Alex Sparreboom

Journal:

Investigational New Drugs

Année:

2006

Langue:

english

Fichier:

PDF, 318 KB

english, 2006

37

Targetable HPMA Copolymer–Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy

Mark P. Borgman, Abhijit Ray, Rohit B. Kolhatkar, Edward A. Sausville, Angelika M. Burger, Hamidreza Ghandehari

Journal:

Pharmaceutical Research

Année:

2009

Langue:

english

Fichier:

PDF, 345 KB

english, 2009

38

RADIOGRAPHIC DIAGNOSIS

Sherril L. Green, Crispin P. Spencer, Michelle Wells, David Sausville

Journal:

Veterinary Radiology & Ultrasound

Année:

1989

Langue:

english

Fichier:

PDF, 703 KB

english, 1989

39

Benign prostatic hyperplasia and prostate cancer: an overview for primary care physicians

J. Sausville, M. Naslund

Journal:

International Journal of Clinical Practice

Année:

2010

Langue:

english

Fichier:

PDF, 205 KB

english, 2010

40

Inhibition of CDKs as a Therapeutic Modality

EDWARD A. SAUSVILLE, JILL JOHNSON, MICHAEL ALLEY, DANIEL ZAHAREVITZ, ADRIAN M. SENDEROWICZ

Journal:

Annals of the New York Academy of Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 3.72 MB

english, 2000

41

A cDNA microarray gene expression database for cancer drug discovery

Weinstein, J.N., Scherf, U., Ross, D., Waltham, M., Reinhold, R., Zhou, Y., Scudiero, D.A., Smith, L.H., Lee, J.K., Shalon, D., Lashkari, D., Eisen, M., Myers, T.M., Sausville, E.A., Botstein, D., Bro

Journal:

Nature Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 91 KB

english, 1999

42

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Nau, Marion M., Brooks, Burke J., Battey, James, Sausville, Edward, Gazdar, Adi F., Kirsch, Ilan R., McBride, O. Wesley, Bertness, Virginia, Hollis, Gregory F., Minna, John D.

Journal:

Année:

1985

Fichier:

PDF, 624 KB

1985

43

Aurora kinases dawn as cancer drug targets

Sausville, Edward A

Journal:

Nature Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 490 KB

english, 2004

44

Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines

Freije, José M.P., Lawrence, Julia A., Hollingshead, Melinda G., De La Rosa, Abel, Narayanan, Ven, Grever, Michael, Sausville, Edward A., Paull, Kenneth, Steeg, Patricia S.

Journal:

Nature Medicine

Année:

1997

Fichier:

PDF, 693 KB

1997

45

Issues and progress with protein kinase inhibitors for cancer treatment

Dancey, Janet, Sausville, Edward A.

Journal:

Nature Reviews Drug Discovery

Année:

2003

Langue:

english

Fichier:

PDF, 618 KB

english, 2003

46

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

Trapani, V, Patel, V, Leong, C-O, Ciolino, H P, Yeh, G C, Hose, C, Trepel, J B, Stevens, M F G, Sausville, E A, Loaiza-Pérez, A I

Journal:

British Journal of Cancer

Année:

2003

Langue:

english

Fichier:

PDF, 221 KB

english, 2003

47

Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

Tudor, G, Aguilera, A, Halverson, D O, Laing, N D, Sausville, E A

Journal:

Cell Death & Differentiation

Année:

2000

Langue:

english

Fichier:

PDF, 336 KB

english, 2000

48

Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

Le, S B, Holmuhamedov, E L, Narayanan, V L, Sausville, E A, Kaufmann, S H

Journal:

Cell Death & Differentiation

Année:

2005

Langue:

english

Fichier:

PDF, 278 KB

english, 2005

49

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

Yu, Chunrong, Rahmani, Mohamed, Almenara, Jorge, Sausville, Edward A, Dent, Paul, Grant, Steven

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 511 KB

english, 2003

50

The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-xL protein

Bhonde, Mandar R, Hanski, Marie-Luise, Magrini, Roberta, Moorthy, Dhatchana, Müller, Antje, Sausville, Edward A, Kohno, Kimitoshi, Wiegand, Peter, Daniel, Peter T, Zeitz, Martin

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 372 KB

english, 2004