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1

Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action

Hossein Razavi, Satheesh K. Palaninathan, Evan T. Powers, R. Luke Wiseman, Hans E. Purkey, Nilofar N. Mohamedmohaideen, Songpon Deechongkit, Kyle P. Chiang, Maria T. A. Dendle, James C. Sacchettini, J

Journal:

Angewandte Chemie

Année:

2003

Langue:

english

Fichier:

PDF, 149 KB

english, 2003

2

Crystal structure of a plant catechol oxidase containing a dicopper center

Klabunde, Thomas, Eicken, Christoph, Sacchettini, James C., Krebs, Bernt

Journal:

Natural Structural Biology

Année:

1998

Langue:

english

Fichier:

PDF, 1.09 MB

english, 1998

3

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

Dessen, A, Quemard, A, Blanchard, J., Jacobs, W., Sacchettini, J.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 1.44 MB

english, 1995

4

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Sun, Qingan, Li, Xiaojun, Perez, Lisa M., Shi, Wanliang, Zhang, Ying, Sacchettini, James C.

Journal:

Nature Communications

Année:

2020

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2020

5

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Joel S. Freundlich, Feng Wang, Catherine Vilchèze, Gulcin Gulten, Robert Langley, Guy A. Schiehser, David P. Jacobus, William R. Jacobs Jr., James C. Sacchettini

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 698 KB

english, 2009

6

Structural genomics approach to drug discovery for Mycobacterium tuberculosis

Thomas R Ioerger, James C Sacchettini

Journal:

Current Opinion in Microbiology

Année:

2009

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2009

7

NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism

Kim, Y., Cunningham, M. A., Mire, J., Tesar, C., Sacchettini, J., Joachimiak, A.

Journal:

The FASEB Journal

Année:

2013

Langue:

english

Fichier:

PDF, 396 KB

english, 2013

8

Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase

Mosser, Rockann, Reddy, Manchi C. M., Bruning, John B., Sacchettini, James C., Reinhart, Gregory D.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 395 KB

english, 2013

9

BIOCHEMISTRY: Creating Isoprenoid Diversity

Sacchettini, J. C.

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 634 KB

english, 1997

10

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

Zhang, Yanjia J., Reddy, Manchi C., Ioerger, Thomas R., Rothchild, Alissa C., Dartois, Veronique, Schuster, Brian M., Trauner, Andrej, Wallis, Deeann, Galaviz, Stacy, Huttenhower, Curtis, Sacchettini,

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.76 MB

english, 2013

11

Reversible Ligand-Induced Dissociation of a Tryptophan-Shift Mutant of Phosphofructokinase from Bacillus stearothermophilus †,‡

Riley-Lovingshimer, Michelle R., Ronning, Donald R., Sacchettini, James C., Reinhart, Gregory D.

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 207 KB

english, 2002

12

Kinetic and Structural Characterization of Phosphofructokinase from Lactobacillus bulgaricus †

Paricharttanakul, N. Monique, Ye, Sheng, Menefee, Ann L., Javid-Majd, Farah, Sacchettini, James C., Reinhart, Gregory D.

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 298 KB

english, 2005

13

TEXTAL: AI-Based Structural Determination for X-ray Protein Crystallography

Romo, T., Gopal, K., McKee, E., Kanbi, L., Reetal Pai,, Smith, J., Sacchettini, J., Ioerger, T.

Journal:

IEEE Intelligent Systems

Année:

2005

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2005

14

Perceptions of pesticides exposure risks by operators, workers, residents and bystanders in Greece, Italy and the UK

Remoundou, K., Brennan, M., Sacchettini, G., Panzone, L., Butler-Ellis, M.C., Capri, E., Charistou, A., Chaideftou, E., Gerritsen-Ebben, M.G., Machera, K., Spanoghe, P., Glass, R., Marchis, A., Doanng

Journal:

Science of The Total Environment

Année:

2015

Langue:

english

Fichier:

PDF, 411 KB

english, 2015

15

Structural and Functional Analyses of the Severe Acute Respiratory Syndrome Coronavirus Endoribonuclease Nsp15

Bhardwaj, K., Palaninathan, S., Alcantara, J. M. O., Li Yi, L., Guarino, L., Sacchettini, J. C., Kao, C. C.

Journal:

Journal of Biological Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2008

16

A General Method for Facilitating Heterodimeric Pairing Between Two Proteins: Application to Expression of α and β T-Cell Receptor Extracellular Segments

Hsiu-Ching Chang, Zheng-Zheng Bao, Yasuko Yao, Albert G. D. Tse, Earl C. Goyarts, Mari Madsen, Ernest Kawasaki, Pamela P. Brauer, James C. Sacchettini, Stanley G. Nathenson and Ellis L. Reinherz

Journal:

Proceedings of the National Academy of Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 1.25 MB

english, 1994

17

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis

Korkegian, Aaron, O'Malley, Theresa, Xia, Yi, Zhou, Yasheen, Carter, David S., Sunde, Bjorn, Flint, Lindsay, Thompson, Dean, Ioerger, Thomas R., Sacchettini, Jim, Alley, M.R.K., Parish, Tanya

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 607 KB

english, 2017

18

Structure-guided design of a potent peptide-inhibitor targeting the interaction between CRK and ABL kinase

Shen, Qingliang, Bhatt, Veer S, Krieger, Inna, Sacchettini, James C, Cho, Jae-Hyun

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2018

19

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold

Salazar, Adam J., Sherekar, Mukul, Tsai, Jennifer, Sacchettini, James C., Mayans, Olga

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 3.58 MB

english, 2019

20

Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action

Hossein Razavi, Satheesh K. Palaninathan, Evan T. Powers, R. Luke Wiseman, Hans E. Purkey, Nilofar N. Mohamedmohaideen, Songpon Deechongkit, Kyle P. Chiang, Maria T. A. Dendle, James C. Sacchettini, J

Journal:

Angewandte Chemie International Edition

Année:

2003

Langue:

english

Fichier:

PDF, 149 KB

english, 2003

21

Electromagnetic fields produced by GSM cellular phones and heart rate variability

Marta Parazzini, Paolo Ravazzani, Gabriella Tognola, György Thuróczy, Ferenc B. Molnar, Alessio Sacchettini, Gianluca Ardesi, Luca Tommaso Mainardi

Journal:

Bioelectromagnetics

Année:

2007

Langue:

english

Fichier:

PDF, 168 KB

english, 2007

22

Hydroxylated Polychlorinated Biphenyls Selectively Bind Transthyretin in Blood and Inhibit Amyloidogenesis: Rationalizing Rodent PCB Toxicity

Hans E. Purkey, Satheesh K. Palaninathan, Kathleen C. Kent, Craig Smith, Stephen H. Safe, James C. Sacchettini, Jeffery W. Kelly

Journal:

Chemistry & Biology

Année:

2004

Langue:

english

Fichier:

PDF, 266 KB

english, 2004

23

Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids

Hector R. Morbidoni, Catherine Vilchèze, Laurent Kremer, Robert Bittman, James C. Sacchettini, William R. Jacobs Jr.

Journal:

Chemistry & Biology

Année:

2006

Langue:

english

Fichier:

PDF, 443 KB

english, 2006

24

Identification of a Type III Thioesterase Reveals the Function of an Operon Crucial for Mtb Virulence

Feng Wang, Robert Langley, Gulcin Gulten, Lei Wang, James C. Sacchettini

Journal:

Chemistry & Biology

Année:

2007

Langue:

english

Fichier:

PDF, 756 KB

english, 2007

25

Mycolic Acid Cyclopropanation is Essential for Viability, Drug Resistance, and Cell Wall Integrity of Mycobacterium tuberculosis

Daniel Barkan, Zhen Liu, James C. Sacchettini, Michael S. Glickman

Journal:

Chemistry & Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2009

26

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Anna C. Giddens, Lone Nielsen, Helena I. Boshoff, Deniz Tasdemir, Remo Perozzo, Marcel Kaiser, Feng Wang, James C. Sacchettini, Brent R. Copp

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 274 KB

english, 2008

27

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

Michelle H. Larsen, Catherine Vilchèze, Laurent Kremer, Gurdyal S. Besra, Linda Parsons, Max Salfinger, Leonid Heifets, Manzour H. Hazbon, David Alland, James C. Sacchettini, William R. Jacobs Jr

Journal:

Molecular Microbiology

Année:

2002

Langue:

english

Fichier:

PDF, 296 KB

english, 2002

28

Solution structure of ileal lipid binding protein in complex with glycocholate

Christian Lücke, Fengli Zhang, James A. Hamilton, James C. Sacchettini, Heinz Rüterjans

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 804 KB

english, 2000

29

Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein

Nishant D. Shetty, Manchi C. M. Reddy, Satheesh K. Palaninathan, Joshua L. Owen, James C. Sacchettini

Journal:

Protein Science

Année:

2010

Langue:

english

Fichier:

PDF, 601 KB

english, 2010

30

Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site

Arulandu Arockiasamy, Anup Aggarwal, Christos G. Savva, Andreas Holzenburg, James C. Sacchettini

Journal:

Protein Science

Année:

2011

Langue:

english

Fichier:

PDF, 285 KB

english, 2011

31

13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium

David P. Cistola, James C. Sacchettini, Jeffrey I. Gordon

Journal:

Molecular and Cellular Biochemistry

Année:

1990

Langue:

english

Fichier:

PDF, 729 KB

english, 1990

32

Expression of rat intestinal fatty acid binding protein inE. coliand its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction

James C. Sacchettini, Leonard J. Banaszak, Jeffrey I. Gordon

Journal:

Molecular and Cellular Biochemistry

Année:

1990

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1990

33

High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions

Giovanna Scapin, Aideen C. M. Young, Arno Kromminga, Jacques H. Veerkamp, Jeffrey I. Gordon, James C. Sacchettini

Journal:

Molecular and Cellular Biochemistry

Année:

1993

Langue:

english

Fichier:

PDF, 825 KB

english, 1993

34

Interannual Antarctic tropospheric circulation and precipitation variability

C. Genthon, G. Krinner, M. Sacchettini

Journal:

Climate Dynamics

Année:

2003

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2003

35

Structural basis of fumarate hydratase deficiency

Sarah Picaud, Kathryn L. Kavanagh, Wyatt W. Yue, Wen Hwa Lee, Susanne Muller-Knapp, Opher Gileadi, James Sacchettini, Udo Oppermann

Journal:

Journal of Inherited Metabolic Disease

Année:

2011

Langue:

english

Fichier:

PDF, 323 KB

english, 2011

36

1H,13C and15N Chemical Shift Assignments of the C-Terminal, 133-Residue Pseudo-Receiver Domain of Circadian Input Kinase (CikA) inSynechococcus elongatus

Tiyu Gao, Xiaofan Zhang, Youlin Xia, Yoonsang Cho, James C. Sacchettini, Susan S. Golden, Andy C. LiWang

Journal:

Journal of Biomolecular NMR

Année:

2005

Langue:

english

Fichier:

PDF, 178 KB

english, 2005

37

Conference report on the European directive on sustainable use of plant protection products (SUD)

Gabriele Sacchettini, Erica Durigon

Journal:

Environmental Science and Pollution Research

Année:

2011

Langue:

english

Fichier:

PDF, 73 KB

english, 2011

38

M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)

Róisín M. Owens, Fong Fu Hsu, Brian C. VanderVen, Georgiana E. Purdy, Elizabeth Hesteande, Peter Giannakas, James C. Sacchettini, John D. McKinney, Preston J. Hill, John T. Belisle, Barbara A. Butcher

Journal:

Molecular Microbiology

Année:

2006

Langue:

english

Fichier:

PDF, 778 KB

english, 2006

39

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis

Ty A. Gould, Helmus Van De Langemheen, Ernesto J. Muñoz-Elías, John D. McKinney, James C. Sacchettini

Journal:

Molecular Microbiology

Année:

2006

Langue:

english

Fichier:

PDF, 262 KB

english, 2006

40

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

Catherine Vilchèze, Yossef Av-Gay, Rodgoun Attarian, Zhen Liu, Manzour H. Hazbón, Roberto Colangeli, Bing Chen, Weijun Liu, David Alland, James C. Sacchettini, William R. Jacobs Jr

Journal:

Molecular Microbiology

Année:

2008

Langue:

english

Fichier:

PDF, 685 KB

english, 2008

41

Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase

Kimberly Payne, Qingan Sun, James Sacchettini, Graham F. Hatfull

Journal:

Molecular Microbiology

Année:

2009

Langue:

english

Fichier:

PDF, 861 KB

english, 2009

42

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

Virginie Molle, Gulcin Gulten, Catherine Vilchèze, Romain Veyron-Churlet, Isabelle Zanella-Cléon, James C. Sacchettini, William R. Jacobs Jr, Laurent Kremer

Journal:

Molecular Microbiology

Année:

2010

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2010

43

Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa)

Xiaomin Cai, A. Lorraine Fuller, Larry R. McDougald, Xiangshi Tan, Jianping Cai, Feng Wang, James C. Sacchettini, Guan Zhu

Journal:

FEMS Microbiology Letters

Année:

2007

Langue:

english

Fichier:

PDF, 290 KB

english, 2007

44

Identification of differentially regulated gene targets in the Myc and Mad family proteins

O'Hagan, Ronan, Schreiber-Agus, Nicole, Engelman, Jeffrey A., Schwab, Richard, Alland, Leila, Thompson, Cole, Ronning, Donald R., Sacchettini, James C., Meltzer, Paul, DePinho, Ronald A.

Journal:

Nature Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 90 KB

english, 1999

45

10.1038/35021074

McKinney, John D., zu Bentrup, Kerstin Höner, Muñoz-Elías, Ernesto J., Miczak, Andras, Chen, Bing, Chan, Wai-Tsing, Swenson, Dana, Sacchettini, James C., Jacobs, William R., Russell, David G.

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 236 KB

english, 2000

46

10.1038/72413

Sacchettini, James C., Ronning, Donald R., Klabunde, Thomas, Besra, Gurdyal S., Vissa, Varalakshmi D., Belisle, John T.

Journal:

Natural Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 533 KB

english, 2000

47

Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

O'Hagan, Rónán C., Schreiber-Agus, Nicole, Chen, Ken, David, Gregory, Engelman, Jeffrey A., Schwab, Richard, Alland, Leila, Thomson, Cole, Ronning, Donald R., Sacchettini, James C.

Journal:

Nature Genetics

Année:

2000

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2000

48

10.1038/74082

Sacchettini, James C., Klabunde, Thomas, Petrassi, H. Michael, Oza, Vibha B., Raman, Prakash, Kelly, Jeffery W.

Journal:

Natural Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2000

49

10.1038/77964

Sharma, Vivek, Sharma, Sujata, zu Bentrup, Kerstin Hoener, McKinney, John D., Russell, David G., Jacobs, William R., Sacchettini, James C.

Journal:

Natural Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 516 KB

english, 2000

50

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

Jacobs, William R, Bornemann, Stephen, Kalscheuer, Rainer, Syson, Karl, Veeraraghavan, Usha, Weinrick, Brian, Biermann, Karolin E, Liu, Zhen, Sacchettini, James C, Besra, Gurdyal

Journal:

Nature Chemical Biology

Année:

2010

Langue:

english

Fichier:

PDF, 909 KB

english, 2010