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1

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

Achim Knappik, Liming Ge, Annemarie Honegger, Peter Pack, Melanie Fischer, Günter Wellnhofer, Adolf Hoess, Joachim Wölle, Andreas Plückthun, Bernhard Virnekäs

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2000

2

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

Plückthun, Andreas

Journal:

Annual Review of Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2015

3

Antibodies from Escherichia coli

Journal:

Année:

1990

Fichier:

PDF, 293 KB

1990

4

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

Anke Krebber, Susanne Bornhauser, Jörg Burmester, Annemarie Honegger, Jörg Willuda, Hans Rudolf Bosshard, Andreas Plückthun

Journal:

Journal of Immunological Methods

Année:

1997

Langue:

english

Fichier:

PDF, 524 KB

english, 1997

5

Improved Bivalent Miniantibodies, with Identical Avidity as Whole Antibodies, Produced by High Cell Density Fermentation of Escherichia coli

Pack, Peter, Kujau, Marian, Schroeckh, Volker, Knüpfer, Uwe, Wenderoth, Rolf, Riesenberg, Dieter, Plückthun, Andreas

Journal:

Nature Biotechnology

Année:

1993

Fichier:

PDF, 1.28 MB

1993

6

The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p

Lubkowski, Jacek, Hennecke, Frank, Plückthun, Andreas, Wlodawer, Alexander

Journal:

Natural Structural Biology

Année:

1998

Fichier:

PDF, 3.40 MB

1998

7

Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA

Jacek Lubkowski, Frank Hennecke, Andreas Plückthun, Alexander Wlodawer

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 195 KB

english, 1999

8

Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

Annemarie Honegger, Andreas Plückthun

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2001

9

Direct Selection of Antibodies from Complex Libraries with the Protein Fragment Complementation Assay

Holger Koch, Nico Gräfe, Ralph Schiess, Andreas Plückthun

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 450 KB

english, 2006

10

Direct identification of ligand-receptor interactions on living cells and tissues

Frei, Andreas P, Jeon, Ock-Youm, Kilcher, Samuel, Moest, Hansjoerg, Henning, Lisa M, Jost, Christian, Plückthun, Andreas, Mercer, Jason, Aebersold, Ruedi, Carreira, Erick M, Wollscheid, Bernd

Journal:

Nature Biotechnology

Année:

2012

Langue:

english

Fichier:

PDF, 620 KB

english, 2012

11

Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy

Simon, Manuel, Stefan, Nikolas, Plückthun, Andreas, Zangemeister-Wittke, Uwe

Journal:

Expert Opinion on Drug Delivery

Année:

2013

Langue:

english

Fichier:

PDF, 712 KB

english, 2013

12

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

Skerra, A, Pluckthun, A

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1988

13

Novel Prodrug-Like Fusion Toxin with Protease-Sensitive Bioorthogonal PEGylation for Tumor Targeting

Stefan, Nikolas, Zimmermann, Martina, Simon, Manuel, Zangemeister-Wittke, Uwe, Plückthun, Andreas

Journal:

Bioconjugate Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.58 MB

english, 2014

14

Antibody Engineering: Advances From the Use of Escherichia coli Expression Systems

Plückthun, Andreas

Journal:

Année:

1991

Fichier:

PDF, 999 KB

1991

15

Determinants of ligand subtype-selectivity at α 1A -adrenoceptor revealed using Saturation Transfer Difference (STD) NMR

Yong, Kelvin J, Vaid, Tasneem M, Shilling, Patrick J, Wu, Feng-Jie, Williams, Lisa M, Deluigi, Mattia, Plückthun, Andreas, Bathgate, Ross AD, Gooley, Paul R., Scott, Daniel J

Journal:

ACS Chemical Biology

Année:

2018

Langue:

english

Fichier:

PDF, 2.01 MB

english, 2018

16

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Yen, Hsin-Yung, Hoi, Kin Kuan, Liko, Idlir, Hedger, George, Horrell, Michael R., Song, Wanling, Wu, Di, Heine, Philipp, Warne, Tony, Lee, Yang, Carpenter, Byron, Plückthun, Andreas, Tate, Christopher

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 6.98 MB

english, 2018

17

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Schöppe, Jendrik, Ehrenmann, Janosch, Klenk, Christoph, Rucktooa, Prakash, Schütz, Marco, Doré, Andrew S., Plückthun, Andreas

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2019

18

High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor

Heine, P., Witt, G., Gilardi, A., Gribbon, P., Kummer, L., Plückthun, Andreas

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2019

19

Direkte Identifizierung von Proteinkatalysatoren mit Phosphatase-Aktivität durch kovalente Bindung an ein Suizid-Substrat

Jason R. Betley, Sandro Cesaro-Tadic, Abdelaziz Mekhalfia, James H. Rickard, Hazel Denham, Lynda J. Partridge, Andreas Plückthun, G. Michael Blackburn

Journal:

Angewandte Chemie

Année:

2002

Fichier:

PDF, 84 KB

2002

20

Direkte Identifizierung von Proteinkatalysatoren mit Phosphatase-Aktivität durch kovalente Bindung an ein Suizid-Substrat

Jason R. Betley, Sandro Cesaro-Tadic, Abdelaziz Mekhalfia, James H. Rickard, Hazel Denham, Lynda J. Partridge, Andreas Plückthun, G. Michael Blackburn

Journal:

Angewandte Chemie

Année:

2002

Fichier:

PDF, 32 KB

2002

21

Direct Screening for Phosphatase Activity by Turnover-Based Capture of Protein Catalysts

Jason R. Betley, Sandro Cesaro-Tadic, Abdelaziz Mekhalfia, James H. Rickard, Hazel Denham, Lynda J. Partridge, Andreas Plückthun, G. Michael Blackburn

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 85 KB

english, 2002

22

Direct Screening for Phosphatase Activity by Turnover-Based Capture of Protein Catalysts

Jason R. Betley, Sandro Cesaro-Tadic, Abdelaziz Mekhalfia, James H. Rickard, Hazel Denham, Lynda J. Partridge, Andreas Plückthun, G. Michael Blackburn

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 41 KB

english, 2002

23

Biotechnological aspects of antibody production in E. coli

Journal:

Acta Biotechnologica

Année:

1991

Langue:

english

Fichier:

PDF, 652 KB

english, 1991

24

Wie rational ist Zufalls-Screening? - Effiziente Methoden der Selektion von Peptid- und Oligonucleotid-Liganden

Priv.-Doz. Dr. Andreas Plückthun, Dr. Liming Ge

Journal:

Angewandte Chemie

Année:

1991

Langue:

german

Fichier:

PDF, 372 KB

german, 1991

25

The Rationality of Random Screening—Efficient Methods of Selection of Peptides and Oligonucleotide Ligands

Priv. Doz. Dr. Andreas Plückthun, Dr. Liming Ge

Journal:

Angewandte Chemie International Edition

Année:

1991

Langue:

english

Fichier:

PDF, 337 KB

english, 1991

26

Combinatorial Approaches To Novel Proteins

Tomoaki Matsuura, Andreas Ernst, David L. Zechel, Andreas Plückthun

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 129 KB

english, 2004

27

Consensus Design of Repeat Proteins

Patrik Forrer, H. Kaspar Binz, Michael T. Stumpp, Andreas Plückthun

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 192 KB

english, 2004

28

Cover Picture: Consensus Design of Repeat Proteins (ChemBioChem 2/2004)

Patrik Forrer, H. Kaspar Binz, Michael T. Stumpp, Andreas Plückthun

Journal:

Année:

2004

Fichier:

PDF, 19 KB

2004

29

Wege zu neuen Enzymen: Protein Engineering und Katalytische Antikörper

Dr. Andreas Plückthun

Journal:

Chemie in unserer Zeit

Année:

1990

Langue:

german

Fichier:

PDF, 9.60 MB

german, 1990

30

Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection

Ulrich Kalinke, Anke Krebber, Claus Krebber, Etienne Bucher, Andreas Plückthun, Rolf M. Zinkernagel, Hans Hengartner

Journal:

European Journal of Immunology

Année:

1996

Langue:

english

Fichier:

PDF, 674 KB

english, 1996

31

Competition BIAcore for Measuring True Affinities: Large Differences from Values Determined from Binding Kinetics

Lars Nieba, Anke Krebber, Andreas Plückthun

Journal:

Analytical Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 224 KB

english, 1996

32

BIACORE Analysis of Histidine-Tagged Proteins Using a Chelating NTA Sensor Chip

Lars Nieba, Sabine E. Nieba-Axmann, Anette Persson, Markku Hämäläinen, Fredrik Edebratt, Anna Hansson, Jonas Lidholm, Kjell Magnusson, Åsa Frostell Karlsson, Andreas Plückthun

Journal:

Analytical Biochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 199 KB

english, 1997

33

Tandem Immobilized Metal-Ion Affinity Chromatography/Immunoaffinity Purification of His-tagged Proteins— Evaluation of Two Anti-His-Tag Monoclonal Antibodies

Kristian M. Müller, Katja M. Arndt, Konrad Bauer, Andreas Plückthun

Journal:

Analytical Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 468 KB

english, 1998

34

Model and Simulation of Multivalent Binding to Fixed Ligands

Kristian M. Müller, Katja M. Arndt, Andreas Plückthun

Journal:

Analytical Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 411 KB

english, 1998

35

Hemolytic assay for venom phospholipase A2

Carl-Wilhelm Vogel, Andreas Plückthun, Hans J. Müller-Eberhard, Edward A. Dennis

Journal:

Analytical Biochemistry

Année:

1981

Langue:

english

Fichier:

PDF, 605 KB

english, 1981

36

Behaviour of polarized ammonia in an intense electron beam

A. Thomas, Ch. Bradtke, H. Dutz, R. Gehring, S. Goertz, H. Hainer, W. Meyer, M. Plückthun, G. Reicherz, K. Runkel

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Année:

1995

Langue:

english

Fichier:

PDF, 364 KB

english, 1995

37

Investigations in high temperature irradiated 6,7LiH and 6LiD, its dynamic nuclear polarization and radiation resistance

St. Goertz, Ch. Bradtke, H. Dutz, R. Gehring, W. Meyer, M. Plückthun, G. Reicherz, K. Runkel, A. Thomas

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Année:

1995

Langue:

english

Fichier:

PDF, 958 KB

english, 1995

38

The Bonn polarized target NMR-system

G. Reicherz, C. Bradtke, H. Dutz, R.M. Gehring, S. Goertz, D. Krämer, W. Meyer, M. Plückthun, A. Thomas

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Année:

1995

Langue:

english

Fichier:

PDF, 439 KB

english, 1995

39

Antibody engineering

Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Année:

1991

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1991

40

Effects of overexpressing folding modulators on the in vivo folding of heterologous proteins in Escherichia coli

J Gerard Wall, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Année:

1995

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1995

41

Polarization measurements of TEMPO-doped butanol targets

M. Plückthun, Ch. Bradtke, H. Dutz, R. Gehring, St. Goertz, J. Harmsen, P. Kingsberry, W. Meyer, G. Reicherz

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Année:

1997

Langue:

english

Fichier:

PDF, 372 KB

english, 1997

42

First use of an internal superconducting ‘holding magnet’ in an η-photoproduction experiment

R. Gehring, H. Dutz, Ch. Bradtke, St. Goertz, W. Meyer, M. Plückthun, G. Reicherz, A. Thomas, H. Werth

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Année:

1998

Langue:

english

Fichier:

PDF, 226 KB

english, 1998

43

A kinetic trap is an intrinsic feature in the folding pathway of single-chain Fv fragments

Wolfgang Hoyer, Kathrin Ramm, Andreas Plückthun

Journal:

Biophysical Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 265 KB

english, 2002

44

AFM structural study of the molecular chaperone GroEL and its two-dimensional crystals: an ideal “living” calibration sample

F. Valle, J.A. DeRose, G. Dietler, M. Kawe, A. Plückthun, G. Semenza

Journal:

Ultramicroscopy

Année:

2002

Langue:

english

Fichier:

PDF, 291 KB

english, 2002

45

Conformational changes and spatial arrangement of the E. coli chaperones GroEL and GroES

R. Stegmann, E. Manakova, S. Axmann, M. Rößle, T. Hermann, R.P. May, A. Wiedenmann, A. Plückthun, H. Heumann

Journal:

Physica B: Condensed Matter

Année:

1997

Langue:

english

Fichier:

PDF, 170 KB

english, 1997

46

In vitro display technologies: novel developments and applications

Patrick Amstutz, Patrik Forrer, Christian Zahnd, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Année:

2001

Langue:

english

Fichier:

PDF, 296 KB

english, 2001

47

Protein engineering

AbrahamM de Vos, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Année:

1996

Langue:

english

Fichier:

PDF, 211 KB

english, 1996

48

Recent advances in producing and selecting functional proteins by using cell-free translation

Lutz Jermutus, Lyubov A Ryabova, Andreas Plückthun

Journal:

Current Opinion in Biotechnology

Année:

1998

Langue:

english

Fichier:

PDF, 1.27 MB

english, 1998

49

Imaging the native structure of the chaperone protein GroEL without fixation using atomic force microscopy

F. Valle, J. A. Derose, G. Dietler, M. Kawe, A. Plückthun, G. Semenza

Journal:

Journal of Microscopy

Année:

2001

Langue:

english

Fichier:

PDF, 138 KB

english, 2001

50

Production of recombinant human β2-microglobulin for scintigraphic diagnosis of amyloidosis in uremia and hemodialysis

Reinhold P. Linke, Jürgen Schäeffer, Peter Gielow, Peter Lindner, Friedrich Lottspeich, Andreas Plückthun, Elisabeth H. Weiss

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 703 KB

english, 2000