Borchelt, David R : rechercher sur Z-Library

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51

APP and PS-1 transgenic mice

David R. Borchelt, Christian Lesuisse, Vicki Gonzales, Jeffrey Anderson, Michael K. Lee, Donald L. Price, Philip C.Y. Wong, Steve Wagner

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 195 KB

english, 2000

52

Aβ as a homeostatic negative regulator of synaptic function?

Flavio Kamenetz, David R. Borchelt, Taisuke Tomita, Takeshi Iwatsubo, Sangram Sisodia, Roberto Malinow

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 344 KB

english, 2000

53

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

David R. Borchelt, Michael K. Lee, Victoria Gonzales, Hilda H. Slunt, Tamara Ratovitski, Nancy A. Jenkins, Neal G. Copeland, Donald L. Price, Sangram S. Sisodia

Journal:

Neurobiology of Aging

Année:

2002

Langue:

english

Fichier:

PDF, 244 KB

english, 2002

54

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer’s Disease neuropathology

Zhongmin Xiang, Lap Ho, Jennifer Valdellon, David Borchelt, Kevin Kelley, Lauren Spielman, Paul S. Aisen, Giulio Maria Pasinetti

Journal:

Neurobiology of Aging

Année:

2002

Langue:

english

Fichier:

PDF, 226 KB

english, 2002

55

S1-01-02 A role for APP and BACE1 in cognition

Philip C. Wong, Huaibin Cai, Fiona M. Laird, Alena V. Savonenko, Tatyana Melnikova, Donald L. Price, David R. Borchelt, Guilian Xu

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 155 KB

english, 2004

56

O4-02-01 Role of LRP and RAP in amyloid deposition

David R. Borchelt, Guilian Xu, Jiou Wang, Victoria Gonzales

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 161 KB

english, 2004

57

P1-222 Deletion of BACE1 prevents age-associated neuropathological abnormalities in mutant APP;PS1 mice

Huaibin Cai, Hongjin Wen, Fiona M. Laird, Hsueh-Cheng Chiang, Guilian Xu, David R. Borchelt, Donald L. Price, Philip C. Wong

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 159 KB

english, 2004

58

P1-179 Age-associated memory deficits occurring in Bace1-deficient mice or APP;PS1 mice are restored in APP;PS1 mice lacking BACE1: a role for APP and BACE1 in cognition

Fiona M. Laird, Alena V. Savonenko, Tatyana Melnikova, Huaibin Cai, David R. Borchelt, Donald L. Price, Philip C. Wong

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 148 KB

english, 2004

59

P2-038 Inhibition of beta-amyloid production and clearance of senile plaques in transgenic mice

Joanna L. Jankowsky, Jason Wen, Hilda H. Slunt, Victoria Gonzales, Nancy A. Jenkins, Neal G. Copeland, David R. Borchelt

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 163 KB

english, 2004

60

Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model

Gabriele Schilling, Michael L Coonfield, Christopher A Ross, David R Borchelt

Journal:

Neuroscience Letters

Année:

2001

Langue:

english

Fichier:

PDF, 268 KB

english, 2001

61

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

Masaaki Takahashi, Sylvain Doré, Christopher D Ferris, Taisuke Tomita, Akira Sawa, Herman Wolosker, David R Borchelt, Takeshi Iwatsubo, Seong-Hun Kim, Gopal Thinakaran, Sangram S Sisodia, Solomon H Sn

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 902 KB

english, 2000

62

Protein Topology of Presenilin 1

Andrew Doan, Gopal Thinakaran, David R Borchelt, Hilda H Slunt, Tamara Ratovitsky, Marcia Podlisny, Dennis J Selkoe, Mary Seeger, Samuel E Gandy, Donald L Price, Sangram S Sisodia

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.66 MB

english, 1996

63

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Gopal Thinakaran, David R Borchelt, Michael K Lee, Hilda H Slunt, Lia Spitzer, Grace Kim, Tamara Ratovitsky, Frances Davenport, Christer Nordstedt, Mary Seeger, John Hardy, Allan I Levey, Samuel E Gan

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 5.23 MB

english, 1996

64

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David R. Borchelt, Gopal Thinakaran, Christopher B. Eckman, Michael K. Lee, Frances Davenport, Tamara Ratovitsky, Cristian-Mihail Prada, Grace Kim, Sophia Seekins, Debra Yager, Hilda H. Slunt, Rong Wa

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 383 KB

english, 1996

65

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

Satoshi Naruse, Gopal Thinakaran, Jin-Jun Luo, John W Kusiak, Taisuke Tomita, Takeshi Iwatsubo, Xiaozhong Qian, David D Ginty, Donald L Price, David R Borchelt, Philip C Wong, Sangram S Sisodia

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 242 KB

english, 1998

66

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

David R Borchelt, Tamara Ratovitski, Judy van Lare, Michael K Lee, Vicki Gonzales, Nancy A Jenkins, Neal G Copeland, Donald L Price, Sangram S Sisodia

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 433 KB

english, 1997

67

An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

Janine A Davis, Satoshi Naruse, Hua Chen, Chris Eckman, Steven Younkin, Donald L Price, David R Borchelt, Sangram S Sisodia, Philip C Wong

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 250 KB

english, 1998

68

APP Processing and Synaptic Function

Flavio Kamenetz, Taisuke Tomita, Helen Hsieh, Guy Seabrook, David Borchelt, Takeshi Iwatsubo, Sangram Sisodia, Roberto Malinow

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 611 KB

english, 2003

69

Transgenic models of neurodegenerative diseases

Michael K Lee, David R Borchelt, Philip C Wong, Sangram S Sisodia, Donald L Price

Journal:

Current Opinion in Neurobiology

Année:

1996

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1996

70

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Alena V Savonenko, Guilian M Xu, Donald L Price, David R Borchelt, Alicja L Markowska

Journal:

Neurobiology of Disease

Année:

2003

Langue:

english

Fichier:

PDF, 548 KB

english, 2003

71

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Jin G Sheng, Susan H Bora, G Xu, David R Borchelt, Donald L Price, Vassilis E Koliatsos

Journal:

Neurobiology of Disease

Année:

2003

Langue:

english

Fichier:

PDF, 718 KB

english, 2003

72

Environmental enrichment mitigates cognitive deficits in APP/PS1 transgenic mice

Joanna L. Jankowsky, Tatiana Melnikova, Daniel J. Fadale, Guilian M. Xu, Hilda H. Slunt, Victoria Gonzales, Linda H. Younkin, Steven G. Younkin, David R. Borchelt, Alena V. Savonenko

Journal:

Alzheimer's & Dementia

Année:

2005

Langue:

english

Fichier:

PDF, 47 KB

english, 2005

73

P-053: Use of a biotinylated anti-Aβ antibody to diagnose preclinical Alzheimer’s disease

Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Journal:

Alzheimer's & Dementia

Année:

2007

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2007

74

A transgenic mouse model of amyloid β oligomers: Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo

Takami Tomiyama, Shogo Matsuyama, Hiroyuki Iso, Hiroshi Takuma, Tomohiro Umeda, Kiyouhisa Ohnishi, Rie Teraoka, Kenichi Ishibashi, Kazuchika Nishitsuji, Kazuhiro Ito, David R. Borchelt, Mary P. Lamber

Journal:

Alzheimer's & Dementia

Année:

2009

Langue:

english

Fichier:

PDF, 57 KB

english, 2009

75

A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo

Mercedes Prudencio, Herman Lelie, Hilda H. Brown, Julian P. Whitelegge, Joan S. Valentine, David R. Borchelt

Journal:

Journal of Neurochemistry

Année:

2012

Langue:

english

Fichier:

PDF, 604 KB

english, 2012

76

Amyotrophic Lateral Sclerosis — Are Microglia Killing Motor Neurons?

Borchelt, David R.

Journal:

Boston Medical and Surgical Journal

Année:

2006

Langue:

english

Fichier:

PDF, 203 KB

english, 2006

77

Regenerative medicine in Alzheimer's disease

Felsenstein, Kevin M., Candelario, Kate M., Steindler, Dennis A., Borchelt, David R.

Journal:

Translational Research

Année:

2014

Langue:

english

Fichier:

PDF, 319 KB

english, 2014

78

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1

Qualls, David A, Prudencio, Mercedes, Roberts, Brittany LT, Crosby, Keith, Brown, Hilda, Borchelt, David R

Journal:

Molecular Neurodegeneration

Année:

2013

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2013

79

Identification of an initial site of interaction and possible helix destabilizing activity preceding initiation of protein synthesis from retrovirus RNA

Borchelt, David, Perdue, Michael L.

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 951 KB

english, 1988

80

Alzheimer's amyloidosis induces global changes in protein homeostasis in the brains of transgenic mice

Xu, Guilian, Stevens, Stanley, Kobeissy, Firas, Gold, Mark, Borchelt, David

Journal:

Alzheimer's & Dementia

Année:

2011

Langue:

english

Fichier:

PDF, 49 KB

english, 2011

81

Influence of base-pairing in the leader region on in vitro translation of Rous sarcoma virus RNA

Borchelt, David, Perdue, Michael L.

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 998 KB

english, 1985

82

P4-343 Papilomarvirus0like particle Aβ vaccine induces specific antibody response, and prevents behavioral impairment in APP/PS1 transgenic mice

Zamora, Eduardo D., Conant, Kathy, Hillaire, Coryse, Handisurya, A., Kirnbauer, Reinhart, Rudow, Gay, Borchelt, David, Troncoso, Juan

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 328 KB

english, 2004

83

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions

Rutherford, Nicola J., Lewis, Jada, Clippinger, Amy K., Thomas, Michael A., Adamson, Jennifer, Cruz, Pedro E., Cannon, Ashley, Xu, Guilian, Golde, Todd E., Shaw, Gerry, Borchelt, David R., Giasson, Be

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 9.44 MB

english, 2013

84

Toxicity of synthetic aβ peptides and modeling of alzheimer's disease

Price, Donald L., Borchelt, David R., Walker, Lary C., Sisodia, Sangram S.

Journal:

Neurobiology of Aging

Année:

1992

Langue:

english

Fichier:

PDF, 324 KB

english, 1992

85

P4-310 Role of presenilin1-β-catenin interaction in embryonic development

Liu, Li, Jankowsky, Joanna, Kordylewska, Anna, Veselits, Margaret, Utset, Manuel, Borchelt, David, Thinakaran, Gopal

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 162 KB

english, 2004

86

P3-195 Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties

Ito, Daisuke, Walker, John R., Thompson, Charlie S., Moroz, Isabella, Veselits, Margaret L., Xu, Guilian M., Borchelt, David R., Hakim, Antoine M., Fienberg, Allen A., Thinakaran, Gopal

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 159 KB

english, 2004

87

Caspase-1 is Activated in Neural Cells and Tissue with Amyotrophic Lateral Sclerosis-Associated Mutations in Copper-Zinc Superoxide Dismutase

Piera Pasinelli, David R. Borchelt, Megan K. Houseweart, Don W. Cleveland and Robert H. Brown

Journal:

Proceedings of the National Academy of Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 1.82 MB

english, 1998

88

Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects || Polyglutamine Pathogenesis

Christopher A. Ross, Jonathan D. Wood, Gabriele Schilling, Matthew F. Peters, Frederick C. Nucifora, Jillian K. Cooper, Alan H. Sharp, Russell L. Margolis and David R. Borchelt

Journal:

Philosophical Transactions Biological Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 1.83 MB

english, 1999

89

Scrapie and Cellular Prion Proteins Differ in Their Kinetics of Synthesis and Topology in Cultured Cells

David R. Borchelt, Michael Scott, Albert Taraboulos, Neil Stahl and Stanley B. Prusiner

Journal:

The Journal of Cell Biology

Année:

1990

Langue:

english

Fichier:

PDF, 2.76 MB

english, 1990

90

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P, Borchelt, David R

Journal:

Acta Neuropathologica Communications

Année:

2014

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2014

91

Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q †

Winkler, Duane D., Schuermann, Jonathan P., Cao, Xiaohang, Holloway, Stephen P., Borchelt, David R., Carroll, Mark C., Proescher, Jody B., Culotta, Valeria C., Hart, P. John

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 4.23 MB

english, 2009

92

Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C

Stahl, Neil, Borchelt, David R., Prusiner, Stanley B.

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 3.51 MB

english, 1990

93

Experimental transmissibility of mutant SOD1 motor neuron disease

Ayers, Jacob I., Fromholt, Susan, Koch, Morgan, DeBosier, Adam, McMahon, Ben, Xu, Guilian, Borchelt, David R.

Journal:

Acta Neuropathologica

Année:

2014

Langue:

english

Fichier:

PDF, 828 KB

english, 2014

94

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease

Ayers, Jacob, Lelie, Herman, Workman, Aron, Prudencio, Mercedes, Brown, Hilda, Fromholt, Susan, Valentine, Joan, Whitelegge, Julian, Borchelt, David

Journal:

Journal of Neurochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 608 KB

english, 2014

95

Corrections: Alzheimer Disease and the Prion Disorders Amyloid β- Protein Amyloidoses

Donald L. Price, David R. Borchelt and Sangram S. Sisodia

Journal:

Proceedings of the National Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 195 KB

english, 1993

96

Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor

Borchelt, David R., Rogers, Mark, Stahl, Neil, Telling, Glenn, Prusiner, Stanley B.

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 9.89 MB

english, 1993

97

Mutations Associated with Amyotrophic Lateral Sclerosis Convert Superoxide Dismutase from an Antiapoptotic Gene to a Proapoptotic Gene: Studies in Yeast and Neural Cells

Shahrooz Rabizadeh, Edith Butler Gralla, David R. Borchelt, Ryder Gwinn, Joan Selverstone Valentine, Sangram Sisodia, Philip Wong, Michael Lee, Hejin Hahn and Dale E. Bredesen

Journal:

Proceedings of the National Academy of Sciences

Année:

1995

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1995

98

ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation

Arrat, Hasan, Lukas, Thomas J., Siddique, Teepu, Borchelt, David R

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 418 KB

english, 2015

99

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains

Janus, Christopher, Flores, Abigail Y., Xu, Guilian, Borchelt, David R.

Journal:

Neurobiology of Aging

Année:

2015

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2015

100

Characterization of Protein Structural Changes in Living Cells Using Time-Lapsed FTIR Imaging

Gelfand, Paul, Smith, Randy J., Stavitski, Eli, Borchelt, David R., Miller, Lisa M.

Journal:

Analytical Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 3.82 MB

english, 2015