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1

Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes

N. Abi-Gerges, G. J. Ji, Z. J. Lu, R. Fischmeister, J. Hescheler, B. K. Fleischmann

Journal:

The Journal of Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 270 KB

english, 2000

2

G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes

Najah Abi-Gerges, Rodolphe Fischmeister, Pierre-François Méry

Journal:

The Journal of Physiology

Année:

2001

Langue:

english

Fichier:

PDF, 342 KB

english, 2001

3

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

Najah Abi-Gerges, Karen Philp, Chris Pollard, Ian Wakefield, Tim G. Hammond, Jean-Pierre Valentin

Journal:

Fundamental & Clinical Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 214 KB

english, 2004

4

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

Najah Abi-Gerges, Jean-Pierre Valentin, Chris E Pollard

Journal:

British Journal of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2010

5

hERG subunit composition determines differential drug sensitivity

N Abi-Gerges, H Holkham, EMC Jones, CE Pollard, J-P Valentin, GA Robertson

Journal:

British Journal of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2011

6

A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes

Najah Abi-Gerges, Leif Hove-Madsen, Rodolphe Fischmeister, Pierre-François Méry

Journal:

British Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 447 KB

english, 1997

7

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

Najah Abi-Gerges, Ben G Small, Chris L Lawrence, Tim G Hammond, Jean-Pierre Valentin, Chris E Pollard

Journal:

British Journal of Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 706 KB

english, 2004

8

Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, β-adrenoceptor stimulation, pacing rate and gender

Najah Abi-Gerges, Ben G Small, Chris L Lawrence, Tim G Hammond, Jean-Pierre Valentin, Chris E Pollard

Journal:

British Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 517 KB

english, 2006

9

NO donors potentiate the β-adrenergic stimulation of ICa,L and the muscarinic activation of IK,ACh in rat cardiac myocytes

Najah Abi-Gerges, Gabor Szabo, Angela S. Otero, Rodolphe Fischmeister, Pierre-François Méry

Journal:

The Journal of Physiology

Année:

2002

Langue:

english

Fichier:

PDF, 561 KB

english, 2002

10

Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels

Rodolphe Fischmeister, Liliana Castro, Aniella Abi-Gerges, Francesca Rochais, Grégoire Vandecasteele

Journal:

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Année:

2005

Langue:

english

Fichier:

PDF, 153 KB

english, 2005

11

Validation of an in vitro contractility assay using canine ventricular myocytes

A.R. Harmer, N. Abi-Gerges, M.J. Morton, G.F. Pullen, J.P. Valentin, C.E. Pollard

Journal:

Toxicology and Applied Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 720 KB

english, 2012

12

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT

M.H. Bridgland-Taylor, A.C. Hargreaves, A. Easter, A. Orme, D.C. Henthorn, M. Ding, A.M. Davis, B.G. Small, C.G. Heapy, N. Abi-Gerges, F. Persson, I. Jacobson, M. Sullivan, N. Albertson, T.G. Hammond,

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2006

Langue:

english

Fichier:

PDF, 419 KB

english, 2006

13

Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™

A.R. Harmer, N. Abi-Gerges, A. Easter, A. Woods, C.L. Lawrence, B.G. Small, J.-P. Valentin, C.E. Pollard

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2008

Langue:

english

Fichier:

PDF, 943 KB

english, 2008

14

Validation of a voltage-sensitive dye-based method for assessing dog myocyte action potential duration

Matthew E.L. Hardy, Ben G. Small, Jean-Pierre Valentin, Chris E. Pollard, Najah Abi-Gerges

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2008

Langue:

english

Fichier:

PDF, 59 KB

english, 2008

15

Comparison of dog myocytes and purkinje fibres for assessment of drug-induced changes in action potential duration

Najah Abi-Gerges, Jean-Pierre Valentin, Chris E. Pollard

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2008

Langue:

english

Fichier:

PDF, 58 KB

english, 2008

16

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

Matthew E.L. Hardy, Chris E. Pollard, Ben G. Small, Matthew Bridgland-Taylor, Ann J. Woods, Jean-Pierre Valentin, Najah Abi-Gerges

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2009

Langue:

english

Fichier:

PDF, 1.87 MB

english, 2009

17

Validation of a cardiac L-type calcium channel assay using IonWorks™

Sahiba Dilbaghi, Najah Abi-Gerges, Micheal J. Morton, Matthew H. Bridgland-Taylor, Chris E. Pollard, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 115 KB

english, 2010

18

hERG1a/1B heteromeric and hERG1a homomeric channels exhibit different pharmacological sensitivities

Harry O. Holkham, Gail A. Robertson, Chris E. Pollard, Jean-Pierre Valentin, Najah Abi-Gerges

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 115 KB

english, 2010

19

Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes

Jérôme Leroy, Aniella Abi-Gerges, Wito Richter, Viacheslav O. Nikolaev, Stefan Engelhardt, Martin J. Lohse, Marco Conti, Rodolphe Fischmeister, Grégoire Vandecasteele

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 53 KB

english, 2007

20

Decreased phosphodiesterase activities in cardiac hypertrophy: Consequences for β-aR regulation of cAMP and ICa,L

A. Abi-Gerges, L.R.V. Castro, J. Leroy, C. Heymes, J.-L. Samuel, C. Lugnier, R. Fischmeister, G. Vandecasteele

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 71 KB

english, 2007

21

PDE4B is the predominant PDE4 isoform regulating the L-type Ca2+ current in mouse ventricular myocytes

J. Leroy, L.R. Castro, A. Abi-Gerges, W. Richter, M. Conti, R. Fischmeister, G. Vandecasteele

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 65 KB

english, 2008

22

IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation

Daniel M. Johnson, Jordi Heijman, Chris E. Pollard, Jean-Pierre Valentin, Harry J.G.M. Crijns, Najah Abi-Gerges, Paul G.A. Volders

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2010

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2010

23

Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes

Pierre-François Méry, Najah Abi-Gerges, Grégoire Vandecasteele, Jonas Jurevicius, Thomas Eschenhagen, Rodolphe Fischmeister

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 665 KB

english, 1997

24

hERG Heteromeric 1A/1B and Homomeric 1A Channels Exhibit Differential Pharmacological Sensitivities

Abi-Gerges, Najah, Holkham, H., Pollard, C.E., Valentin, J.P., Robertson, Gail A.

Journal:

Biophysical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 37 KB

english, 2010

25

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

Di Veroli, G. Y., Davies, M. R., Zhang, H., Abi-Gerges, N., Boyett, M. R.

Journal:

AJP Heart and Circulatory Physiology

Année:

2013

Langue:

english

Fichier:

PDF, 4.89 MB

english, 2013

26

Preservation of cardiomyocytes from the adult heart

Abi-Gerges, Najah, Pointon, Amy, Pullen, Georgia F., Morton, Michael J., Oldman, Karen L., Armstrong, Duncan, Valentin, Jean-Pierre, Pollard, Christopher E.

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2013

Langue:

english

Fichier:

PDF, 811 KB

english, 2013

27

PTFE-matrix membrane

Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.

Journal:

Membrane Technology

Année:

1991

Langue:

english

Fichier:

PDF, 169 KB

english, 1991

28

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2013

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2013

29

THE COMPARATIVE EFFICIENCY OF SILVER NITRATE, PROTARGOL, AND ARGYROL.

Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.

Journal:

Année:

1907

Langue:

english

Fichier:

PDF, 174 KB

english, 1907

30

Increased ICaL Underlies Ventricular Action-Potential Prolongation After Spontaneous Ca2+ Release From The Sarcoplasmic Reticulum

Johnson, D.M., Heijman, J., Bode, E.F., Greensmith, D.J., Abi-Gerges, N., Eisner, D.A., Trafford, A.W., Volders, P.G.A.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 103 KB

english, 2011

31

An Impedance-Based Cellular Assay Using Human iPSC-Derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility

Scott, C. W., Zhang, X., Abi-Gerges, N., Lamore, S. D., Abassi, Y. A., Peters, M. F.

Journal:

Toxicological Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 202 KB

english, 2014

32

Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes

Sassi, Y., Abi-Gerges, A., Fauconnier, J., Mougenot, N., Reiken, S., Haghighi, K., Kranias, E. G., Marks, A. R., Lacampagne, A., Engelhardt, S., Hatem, S. N., Lompre, A.-M., Hulot, J.-S.

Journal:

The FASEB Journal

Année:

2012

Langue:

english

Fichier:

PDF, 675 KB

english, 2012

33

hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

DI VEROLI, GIOVANNI Y., DAVIES, MARK R., ZHANG, HENGGUI, ABI-GERGES, NAJAH, BOYETT, MARK R.

Journal:

Journal of Cardiovascular Electrophysiology

Année:

2014

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2014

34

Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Pointon, A., Harmer, A. R., Dale, I. L., Abi-Gerges, N., Bowes, J., Pollard, C., Garside, H.

Journal:

Toxicological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 931 KB

english, 2015

35

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2014

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2014

36

Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K + channel

Mannikko, R, Bridgland-Taylor, M H, Pye, H, Swallow, S, Abi-Gerges, N, Morton, M J, Pollard, C E

Journal:

British Journal of Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2015

37

Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on -Adrenergic cAMP Signals

Abi-Gerges, A., Richter, W., Lefebvre, F., Mateo, P., Varin, A., Heymes, C., Samuel, J.-L., Lugnier, C., Conti, M., Fischmeister, R., Vandecasteele, G.

Journal:

Circulation Research

Année:

2009

Langue:

english

Fichier:

PDF, 602 KB

english, 2009

38

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

Pointon, A., Abi-Gerges, N., Cross, M. J., Sidaway, J. E.

Journal:

Toxicological Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 803 KB

english, 2013

39

Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases

Fischmeister, R., Castro, L. R.V., Abi-Gerges, A., Rochais, F., Jurevicius, J., Leroy, J., Vandecasteele, G.

Journal:

Circulation Research

Année:

2006

Langue:

english

Fichier:

PDF, 409 KB

english, 2006

40

Spatiotemporal Dynamics of -Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases

Leroy, J., Abi-Gerges, A., Nikolaev, V. O., Richter, W., Lechene, P., Mazet, J.-L., Conti, M., Fischmeister, R., Vandecasteele, G.

Journal:

Circulation Research

Année:

2008

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2008

41

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After -Adrenergic Stimulation

Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W., Volders, P. G. A.

Journal:

Circulation Research

Année:

2013

Langue:

english

Fichier:

PDF, 2.61 MB

english, 2013

42

Enhanced Characterization of Contractility in Cardiomyocytes During Early Drug Safety Assessment

Butler, L., Cros, C., Oldman, K. L., Harmer, A. R., Pointon, A., Pollard, C. E., Abi-Gerges, N.

Journal:

Toxicological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2015

43

Interventricular Differences in -Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases

Molina, C. E., Johnson, D. M., Mehel, H., Spatjens, R. L. H. M. G., Mika, D., Algalarrondo, V., Slimane, Z. H., Lechene, P., Abi-Gerges, N., van der Linde, H. J., Leroy, J., Volders, P. G. A., Fischme

Journal:

Journal of the American Heart Association

Année:

2014

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2014

44

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Le

Journal:

Journal of Biomolecular Screening

Année:

2015

Langue:

english

Fichier:

PDF, 851 KB

english, 2015

45

The combined ion channel blocker AZD1305 attenuates late Na current and IKr-induced action potential prolongation and repolarization instability

B. Andersson, N. Abi-gerges, L. Carlsson

Année:

2010

Langue:

english

Fichier:

PDF, 228 KB

english, 2010

46

Sequential Changes in Autonomic Regulation of Cardiac Myocytes after In Vivo Endotoxin Injection in Rat

ABI-GERGES, NAJAH, TAVERNIER, BENOIT, MEBAZAA, ALEXANDRE, FAIVRE, VALÉRIE, PAQUERON, XAVIER, PAYEN, DIDIER, FISCHMEISTER, RODOLPHE, MÉRY, PIERRE-FRANÇOIS

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

1999

Langue:

english

Fichier:

PDF, 361 KB

english, 1999

47

Would field potential duration, recorded from human induced pluripotent stem cell-derived cardiomyocytes, have utility as an early QT screen?

Abi-Gerges, Najah, Oldman, Karen L., Garside, Helen, Pointon, Amy, Pollard, Chris E.

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2015

Langue:

english

Fichier:

PDF, 50 KB

english, 2015

48

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rodriguez, Blanca, Carusi, Annamaria, Abi-Gerges, Najah, Ariga, Rina, Britton, Oliver, Bub, Gil, Bueno-Orovio, Alfonso, Burton, Rebecca A. B., Carapella, Valentina, Cardone-Noott, Louie, Daniels, Matt

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2015

49

Developing a medium throughput cellular assay to quantify modulators of contractility using human induced pluripotent stem cell-derived cardiomyocytes

Scott, Clay W., Zhang, Xiaoyu, Peters, Matt F., Abassi, Yama A., Abi-Gerges, Najah

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2014

Langue:

english

Fichier:

PDF, 61 KB

english, 2014

50

Enhanced characterization of inotropy in cardiomyocytes paced at different frequencies

Butler, Larissa, Cros, Caroline, Harmer, Alex, Pointon, Amy, Pollard, Chris, Abi-Gerges, Najah

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2015

Langue:

english

Fichier:

PDF, 46 KB

english, 2015